PME-2 (Caenorhabditis elegans)
Description [+]
- Synonyms: PME-2
- Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
- Short gene description: pme-2 encodes a poly(ADP-ribose) polymerase (PARP) orthologous to human PARP2 (OMIM:607725). PME-2 has a predicted C-terminal catalytic domain. PME-2 has PARP activity in vitro, which is blocked by mammalian PARP inhibitors. since these inhibitors also cause embryonic lethality in worms exposed to ionizing radiation, PME-1 is likely to be required in vivo for repairing broken DNA. [Source: WormBase]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: PME-2-C_elegans
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
| Source | Domain Name | Start | End |
|---|---|---|---|
| PFAM A | WGR | 7 | 89 |
| PFAM A | PARP_reg | 171 | 302 |
| PFAM A | PARP | 304 | 528 |
Protein sequence [+]
pme-2 | Caenorhabditis elegans | 6239 | length:538
MSIINDENGRGYKVHLCKTNIAQNNNKFYDMELLDEGGDFIVKLINGRIGYRGVTQLKDF
DDLDRAKKFFESKFYEKTHLHWEERDDEPVPNKYAVVELATNARQTEKEVKKEEPEPEPK
VDEKNTRGRKKRGIVKEKKEIKKEEEPVEEVNEKLKELMKCICDEDVHLGLLKQLKFNEA
FGRPIDCLSLAQLTTGYEILSKIEESIGGKSARRSTRGRPRVADRVLAVKSDGPSLHDIN
KYYSLIPHSFGFCVPPKIDSHAKIQAERELLDALKGSIEASLELKDLKKTASSKDIYQRL
YERLPCHLEPVSEEIAGKIGDCLAMRGPTHCYKLSLIDAFELKDPNEIPTEAPVEVQEVP
KKRGRKSTKTAAPTVPPPTTKRLLWHGTRVTNVFSILMNGLQFPVGDRCGLMFGNGVYFA
NVPTKSANYCCPEASKRVFMLLCEVETANPLVLYESEIDADEKMEKAKKTSVYAAGKHTP
RDTVEINGIPAFKSNLETIEEETRLLYDEYVMFNKEHFKIKYVVEVKVDRLTAKEMMA
DDLDRAKKFFESKFYEKTHLHWEERDDEPVPNKYAVVELATNARQTEKEVKKEEPEPEPK
VDEKNTRGRKKRGIVKEKKEIKKEEEPVEEVNEKLKELMKCICDEDVHLGLLKQLKFNEA
FGRPIDCLSLAQLTTGYEILSKIEESIGGKSARRSTRGRPRVADRVLAVKSDGPSLHDIN
KYYSLIPHSFGFCVPPKIDSHAKIQAERELLDALKGSIEASLELKDLKKTASSKDIYQRL
YERLPCHLEPVSEEIAGKIGDCLAMRGPTHCYKLSLIDAFELKDPNEIPTEAPVEVQEVP
KKRGRKSTKTAAPTVPPPTTKRLLWHGTRVTNVFSILMNGLQFPVGDRCGLMFGNGVYFA
NVPTKSANYCCPEASKRVFMLLCEVETANPLVLYESEIDADEKMEKAKKTSVYAAGKHTP
RDTVEINGIPAFKSNLETIEEETRLLYDEYVMFNKEHFKIKYVVEVKVDRLTAKEMMA
Structure links:
Evolution [+]
Explore tree at phylomeDB: Click here.
DeathBase uses Jalview, an external application that requires Java. Please, check that you have the latest version of Java
installed and that Java is enabled in your browser. When correctly installed your browser should display the following examples properly. You can download the latest version of Java at Java Download Site.
KEGG Pathways [+]
Information from other databases [+]
- entrezgene: 3565967
- refseq_dna: NM_001026886
- refseq_peptide: NP_001022057
Click on [?] for more information.
