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EGL-1   (Caenorhabditis elegans)

Description [+]
  • Synonyms: EGL-1
  • Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
  • Short gene description: egl-1 encodes a novel protein that contains a region similar to the BH3 (Bcl-2 homology region 3) domain of mammalian cell death activators. EGL-1 functions as an upstream activator in the general programmed cell death pathway and positively regulates programmed cell death by interacting directly with CED-9 to induce CED-4 release from CED-4/CED-9 complexes and ultimately activate the CED-3 caspase. EGL-1 also induces WAH-1/apoptosis-inducing factor release from the mitochondria. in hermaphrodites, egl-1 is transcriptionally repressed by TRA-1, permitting survival of the HSN neurons required for egg laying. egl-1 message is detected at low abundance in embryonic and L1 larval mRNA preparations, but not in mRNA preparations from later larval stages or young adults. [Source: WormBase]
  • Family: Bcl-2 family : BH3-only
  • Process: apoptosis,
  • Pathways:
  • Criteria: manually curated
  • Curator comment:
  • WIKI: EGL-1-C_elegans
References [+]
Structure & Sequence [+]
Evolution [+]
Information from other databases [+]