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CRT-1   (Caenorhabditis elegans)

Description [+]
  • Synonyms: CRT-1
  • Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
  • Short gene description: crt-1 encodes an ortholog of calreticulin (a calcium-binding molecular chaperone of the endoplasmic reticulum). crt-1 is dispensable for viability, but required for normal sperm development, male mating efficiency, some forms of necrotic cell death, and hermaphrodite fertility at high temperatures (which may reflect a stress response). crt-1 expression is induced by stress. CRT-1 protein binds Ca(2+) and can suppress heat-induced protein aggregation in vitro. crt-1(bz29) and crt-1(bz30) mutants suppress necrotic cell death induced either by mec-4(d) or by a constitutively activated Gas subunit. crt-1(bz29). crt-1's suppression of necrosis is itself partly reversed by thapsigargin, which enhances calcium release from the endoplasmic reticulum. crt-1(bz30), and crt-1(jh101) mutants grow more slowly, and have have reduced broods at 25 deg. C.. crt-1(jh101) mutants are slightly shorter than normal and have defective sperm. CRT-1 and ITR-1 serve partly redundant functions in vivo, since crt-1.itr-1(sa73) are highly infertile and slow-growing with greatly slowed defecation. a number of proteins, notably HSP-3/4 and PDI-2/3, are over-expressed in crt-1(jh101) mutants and crt-1(jh101).cnx-1(nr2009) double mutants. [Source: WormBase]
  • Family: Null
  • Process:
  • Pathways:
  • Criteria: homology search
  • Curator comment: Null
  • WIKI: CRT-1-C_elegans
Structure & Sequence [+]
Evolution [+]
Information from other databases [+]