CED-1 (Caenorhabditis elegans)
Description [+]
- Synonyms: CED-1,
- Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
- Short gene description: The ced-1 gene encodes a transmembrane protein on phagocytic cells that is homologous to human CD91, a low density lipoprotein receptor paralog. the cytoplasmic tail of CED-1 contains two motifs important for engulfment. [Source: WormBase]
- Family: other
- Process: apoptosis,
- Pathways: apoptotic cell clearance,
- Criteria: manually curated
- Curator comment: CED-1 is a transmembrane receptor, similar to CD91/LRP scavenger receptors.
- Human ortholog(s): MEGF11 PEAR1 MEGF10
- WIKI: CED-1-C_elegans
References [+]
- CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans.
- Zhou Z, Hartwieg E, Horvitz HR
- We cloned the C. elegans gene ced-1, which is required for the engulfment of cells undergoing programmed cell death. ced-1 encodes a transmembrane protein similar to human SREC (Scavenger Receptor from Endothelial Cells). We showed that ced-1 is expressed in and functions in engulfing cells. The CED-1 protein localizes to cell membranes and clusters around neighboring cell corpses. CED-1 failed to cluster around cell corpses in mutants defective in the engulfment gene ced-7. Motifs in the intracellular domain of CED-1 known to interact with PTB and SH2 domains were necessary for engulfment but not for clustering. Our results indicate that CED-1 is a cell surface phagocytic receptor that recognizes cell corpses. We suggest that the ABC transporter CED-7 promotes cell corpse recognition by CED-1, possibly by exposing a phospholipid ligand on the surfaces of cell corpses. Cell. 2001 Jan 12;104(1):43-56.
- Tales of cannibalism, suicide, and murder: Programmed cell death in C. elegans.
- Kinchen JM, Hengartner MO
- Life is pleasant. Death is peaceful. It's the transition that's troublesome, said Isaac Asimov. Indeed, much scientific work over the last hundred years centered around attempts either to stave off or to induce the onset of death, at both the organismal and the cellular levels. In this quest, the nematode C. elegans has proven an invaluable tool, first, in the articulation of the genetic pathway by which programmed cell death proceeds, and also as a continuing source of inspiration. It is our purpose in this Chapter to familiarize the reader with the topic of programmed cell death in C. elegans and its relevance to current research in the fields of apoptosis and cell corpse clearance. Curr Top Dev Biol. 2005;65:1-45.
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
| Source | Domain Name | Start | End |
|---|---|---|---|
| PFAM A | Laminin_EGF | 334 | 386 |
| PFAM A | Laminin_EGF | 424 | 473 |
| PFAM A | Laminin_EGF | 776 | 818 |
| PFAM A | Laminin_EGF | 819 | 870 |
Protein sequence [+]
ced-1 | Caenorhabditis elegans | 6239 | length:1111
MRLILLVLLATWQVVVDTRAPTFPDKLTQQLQQQGTTEPQGDHVCTVKTIVDDYELKKVI
HTVVYNDTEQCLNPLTGFQCTVEKRGQKASYQRQLVKKEKYVKQCCDGYYQTKDHFCLPD
CNPPCKKGKCIEPGKCECDPGYGGKYCASSCSVGTWGLGCSKSCDCENGANCDPELGTCI
CTSGFQGERCEKPCPDNKWGPNCVKSCPCQNGGKCNKEGKCVCSDGWGGEFCLNKCEEGK
FGAECKFECNCQNGATCDNTNGKCICKSGYHGALCENECSVGFFGSGCTQKCDCLNNQNC
DSSSGECKCIGWTGKHCDIGCSRGRFGLQCKQNCTCPGLEFSDSNASCDAKTGQCQCESG
YKGPKCDERKCDAEQYGADCSKTCTCVRENTLMCAPNTGFCRCKPGFYGDNCELACSKDS
YGPNCEKQAMCDWNHASECNPETGSCVCKPGRTGKNCSEPCPLDFYGPNCAHQCQCNQRG
VGCDGADGKCQCDRGWTGHRCEHHCPADTFGANCEKRCKCPKGIGCDPITGECTCPAGLQ
GANCDIGCPEGSYGPGCKLHCKCVNGKCDKETGECTCQPGFFGSDCSTTCSKGKYGESCE
LSCPCSDASCSKQTGKCLCPLGTKGVSCDQKCDPNTFGFLCQETVTPSPCASTDPKNGVC
LSCPPGSSGIHCEHNCPAGSYGDGCQQVCSCADGHGCDPTTGECICEPGYHGKTCSEKCP
DGKYGYGCALDCPKCASGSTCDHINGLCICPAGLEGALCTRPCSAGFWGNGCRQVCRCTS
EYKQCNAQTGECSCPAGFQGDRCDKPCEDGYYGPDCIKKCKCQGTATSSCNRVSGACHCH
PGFTGEFCHALCPESTFGLKCSKECPKDGCGDGYECDAAIGCCHVDQMSCGKAKQEFEAL
NGAGRSTGLTWFFVLLIVALCGGLGLIALFYRNKYQKEKDPDMPTVSFHKAPNNDEGREF
QNPLYSRQSVFPDSDAFSSENNGNHQGGPPNGLLTLEEEELENKKIHGRSAAGRGNNDYA
SLDEVAGEGSSSSASASASRRGLNSSEQSRRPLLEEHDEEEFDEPHENSISPAHAVTTSN
HNENPYADISSPDPVTQNSANKKRAQDNLYT
HTVVYNDTEQCLNPLTGFQCTVEKRGQKASYQRQLVKKEKYVKQCCDGYYQTKDHFCLPD
CNPPCKKGKCIEPGKCECDPGYGGKYCASSCSVGTWGLGCSKSCDCENGANCDPELGTCI
CTSGFQGERCEKPCPDNKWGPNCVKSCPCQNGGKCNKEGKCVCSDGWGGEFCLNKCEEGK
FGAECKFECNCQNGATCDNTNGKCICKSGYHGALCENECSVGFFGSGCTQKCDCLNNQNC
DSSSGECKCIGWTGKHCDIGCSRGRFGLQCKQNCTCPGLEFSDSNASCDAKTGQCQCESG
YKGPKCDERKCDAEQYGADCSKTCTCVRENTLMCAPNTGFCRCKPGFYGDNCELACSKDS
YGPNCEKQAMCDWNHASECNPETGSCVCKPGRTGKNCSEPCPLDFYGPNCAHQCQCNQRG
VGCDGADGKCQCDRGWTGHRCEHHCPADTFGANCEKRCKCPKGIGCDPITGECTCPAGLQ
GANCDIGCPEGSYGPGCKLHCKCVNGKCDKETGECTCQPGFFGSDCSTTCSKGKYGESCE
LSCPCSDASCSKQTGKCLCPLGTKGVSCDQKCDPNTFGFLCQETVTPSPCASTDPKNGVC
LSCPPGSSGIHCEHNCPAGSYGDGCQQVCSCADGHGCDPTTGECICEPGYHGKTCSEKCP
DGKYGYGCALDCPKCASGSTCDHINGLCICPAGLEGALCTRPCSAGFWGNGCRQVCRCTS
EYKQCNAQTGECSCPAGFQGDRCDKPCEDGYYGPDCIKKCKCQGTATSSCNRVSGACHCH
PGFTGEFCHALCPESTFGLKCSKECPKDGCGDGYECDAAIGCCHVDQMSCGKAKQEFEAL
NGAGRSTGLTWFFVLLIVALCGGLGLIALFYRNKYQKEKDPDMPTVSFHKAPNNDEGREF
QNPLYSRQSVFPDSDAFSSENNGNHQGGPPNGLLTLEEEELENKKIHGRSAAGRGNNDYA
SLDEVAGEGSSSSASASASRRGLNSSEQSRRPLLEEHDEEEFDEPHENSISPAHAVTTSN
HNENPYADISSPDPVTQNSANKKRAQDNLYT
Evolution [+]
View protein alignment and tree with Jalview:
Explore tree at phylomeDB: Click here.
Homologs list [+]
| Name | Relationship | Species |
|---|---|---|
| A_aegypti_AAEL008198-PA | orthology | Aedes |
| A_gambiae_AGAP007256-PA | orthology | Anopheles |
| MEGF11 | orthology | Chicken |
| IPI00580976.3 | orthology | Chicken |
| PEAR1 | orthology | Chimpanzee |
| XR_025326.1 | orthology | Chimpanzee |
| MEGF10 | orthology | Chimpanzee |
| MEGF11 | orthology | Cow |
| Q2KJ78_BOVIN | orthology | Cow |
| NP_001094770.1 | orthology | Cow |
| MEGF11 | orthology | Dog |
| PEAR1 | orthology | Dog |
| MEGF10 | orthology | Dog |
| drpr | orthology | Fly |
| PEAR1 | orthology | Fugu |
| MEGF11 (2 of 2) | orthology | Fugu |
| MEGF11 (1 of 2) | orthology | Fugu |
| MEGF11 (2 of 2) | orthology | Gasterosteus |
| MEGF10 | orthology | Gasterosteus |
| MEGF11 (1 of 2) | orthology | Gasterosteus |
| PEAR1 | orthology | Gasterosteus |
| PEAR1 | orthology | Gorilla |
| MEGF10 | orthology | Gorilla |
| MEGF11 | orthology | Gorilla |
| MEGF11 | orthology | Horse |
| MEGF10 | orthology | Horse |
| PEAR1 | orthology | Horse |
| MEGF11 | orthology | Human |
| PEAR1 | orthology | Human |
| MEGF10 | orthology | Human |
| MEGF10 | orthology | Lyzard |
| MEGF11 | orthology | Lyzard |
| PEAR1 | orthology | Lyzard |
| PEAR1 | orthology | Macaca |
| MEGF11 | orthology | Macaca |
| MEGF10 | orthology | Macaca |
| MEGF11 (1 of 2) | orthology | Medaka |
| MEGF11 (2 of 2) | orthology | Medaka |
| MEGF10 | orthology | Medaka |
| MEGF11 | orthology | Monodelphis |
| MEGF10 | orthology | Monodelphis |
| LOC100023818 | orthology | Monodelphis |
| Pear1 | orthology | Mouse |
| Megf10 | orthology | Mouse |
| Megf11 | orthology | Mouse |
| PEAR1 | orthology | Orangutan |
| MEGF10 | orthology | Orangutan |
| MEGF10 | orthology | Ornithorhynchus |
| MEGF11 | orthology | Ornithorhynchus |
| MEGF10 | orthology | Rabbit |
| MEGF11 | orthology | Rabbit |
| Megf11 | orthology | Rat |
| Q63404_RAT | orthology | Rat |
| NP_001128431.1 | orthology | Rat |
| MEGF11 (2 of 2) | orthology | Tetraodon |
| MEGF11 (1 of 2) | orthology | Tetraodon |
| PEAR1 | orthology | Tetraodon |
| MEGF11 | orthology | Xenopus |
| PEAR1 | orthology | Xenopus |
| MEGF10 | orthology | Zebra finch |
| MEGF11 | orthology | Zebra finch |
| PEAR1 | orthology | Zebrafish |
| MEGF10 | orthology | Zebrafish |
| megf11 | orthology | Zebrafish |
| A_aegypti_AAEL010210-PA | paralogy | Aedes |
| Q9W737_CHICK | paralogy | Chicken |
| Q9DEC9_CHICK | paralogy | Chicken |
| IPI00587188.2 | paralogy | Chicken |
| MEGF6 | paralogy | Chicken |
| MEGF6 | paralogy | Chimpanzee |
| XR_024514.1 | paralogy | Chimpanzee |
| NA | paralogy | Ciona |
| NA | paralogy | Ciona |
| NA | paralogy | Ciona |
| NA | paralogy | Ciona |
| XR_042638.1 | paralogy | Cow |
| IPI00711101.4 | paralogy | Cow |
| IPI00703880.3 | paralogy | Cow |
| IPI00690576.4 | paralogy | Cow |
| B_taurus_ENSBTAP00000016682 | paralogy | Cow |
| SCARF1 | paralogy | Dog |
| SCARF2 | paralogy | Dog |
| MEGF6 | paralogy | Dog |
| NOTCH1 | paralogy | Dog |
| wb | paralogy | Fly |
| N | paralogy | Fly |
| MEGF6 | paralogy | Fugu |
| NOTCH1 (2 of 2) | paralogy | Fugu |
| SCARF1 | paralogy | Fugu |
| NOTCH1 (1 of 2) | paralogy | Fugu |
| SCARF2 | paralogy | Fugu |
| G_aculeatus_ENSGACP00000009694 | paralogy | Gasterosteus |
| MEGF6 | paralogy | Gasterosteus |
| SCARF2 | paralogy | Gasterosteus |
| SCARF1 | paralogy | Gasterosteus |
| MEGF6 | paralogy | Gorilla |
| NOTCH3 | paralogy | Horse |
| MEGF6 | paralogy | Horse |
| SCARF2 | paralogy | Horse |
| SCARF1 | paralogy | Human |
| LAMB1 | paralogy | Human |
| KLHL22 | paralogy | Human |
| MEGF6 | paralogy | Human |
| A_carolinensis_ENSACAP00000015331 | paralogy | Lyzard |
| SCARF2 | paralogy | Lyzard |
| MEGF6 | paralogy | Lyzard |
| SCARF2 | paralogy | Macaca |
| MEGF6 | paralogy | Macaca |
| SCARF1 | paralogy | Macaca |
| O_latipes_ENSORLP00000015014 | paralogy | Medaka |
| NOTCH1 (2 of 2) | paralogy | Medaka |
| MEGF6 | paralogy | Medaka |
| SCARF1 | paralogy | Medaka |
| SCARF2 | paralogy | Medaka |
| NOTCH1 | paralogy | Monodelphis |
| M_domestica_ENSMODP00000020159 | paralogy | Monodelphis |
| SCARF1 | paralogy | Monodelphis |
| MEGF6 | paralogy | Monodelphis |
| Notch3 | paralogy | Mouse |
| Scarf1 | paralogy | Mouse |
| Notch1 | paralogy | Mouse |
| Megf6 | paralogy | Mouse |
| Scarf2 | paralogy | Mouse |
| Tnc | paralogy | Mouse |
| MEGF6 | paralogy | Orangutan |
| SCARF1 | paralogy | Orangutan |
| MEGF6 | paralogy | Ornithorhynchus |
| O_anatinus_ENSOANP00000028325 | paralogy | Ornithorhynchus |
| NP_001099334.1 | paralogy | Rat |
| NOTC3_RAT | paralogy | Rat |
| B4F7A0_RAT | paralogy | Rat |
| MEGF6_RAT | paralogy | Rat |
| NP_001100492.1 | paralogy | Rat |
| NOTC1_RAT | paralogy | Rat |
| NOTCH1 (1 of 2) | paralogy | Tetraodon |
| SCARF2 | paralogy | Tetraodon |
| MEGF6 | paralogy | Tetraodon |
| Y64G10A.7 | paralogy | Worm |
| epi-1 | paralogy | Worm |
| SCARF2 | paralogy | Xenopus |
| MEGF6 | paralogy | Xenopus |
| NOTCH1 | paralogy | Xenopus |
| SCARF2 | paralogy | Zebra finch |
| T_guttata_ENSTGUP00000011389 | paralogy | Zebra finch |
| SCARF1 | paralogy | Zebra finch |
| NOTCH2 | paralogy | Zebra finch |
| MEGF6 | paralogy | Zebra finch |
| lamb4 | paralogy | Zebrafish |
| D_rerio_ENSDARP00000090349 | paralogy | Zebrafish |
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Gene Ontology [+]
| GO id | Name | Ontology type | Evidence |
|---|---|---|---|
| GO:0006810 | transport | biological_proccess | IEA |
| GO:0005515 | protein binding | mollecular_function | IPI |
| GO:0016020 | membrane | cell_component | IEA |
Check GO Evidence Codes here
