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WAH-1   (Caenorhabditis elegans)

Description [+]
  • Synonyms: WAH-1
  • Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
  • Short gene description: wah-1 encodes a putative flavin-adenine dinucleotide (FAD)-binding oxidoreductase orthologous to mammalian PDCD8 (AIF. OMIM:300169, mutated in Harlequin mice). WAH-1 is required for apoptotic DNA degratation, SCRM-1 phospholipid scramblase activity, phosphatidylserine exposure, rapid apoptosis during embryonic development, and rapid engulfment of apoptotic cells in the germline. WAH-1 is also required for normally rapid growth and large brood sizes, and has a subtle proapoptotic function revealed in ced-3 or ced-4 mutant backgrounds. WAH-1 is expressed in most, if not all, cells of embryos and larvae. WAH-1 is normally mitochondrial, but can be released into the cytosol and nucleus by EGL-1 and CED-3. residues 380-550 of WAH-1 specifically bind SCRM-1 in vitro, but not SCRM-2 through SCRM-4, and WAH-1 binding is required in liposomes for more than residual SCRM-1 activity. WAH-1 also binds and activates CPS-6, promoting apoptotic DNA degradation, and transgenic coexpression of WAH-1 with CPS-6 specifically induces ectopic CED-3-dependent apoptosis in touch receptor neurons. CPS-6 shares a genetic pathway with WAH-1, whereas CED-3, CED-4, CED-8, and NUC-1 act independently of it. WAH-1 is paralogous to C. elegans F20D6.11 and human AIFM3 (AIFL). [Source: WormBase]
  • Family: other
  • Process: apoptosis,
  • Pathways:
  • Criteria: manually curated
  • Curator comment:
  • Human ortholog(s): AIF
  • WIKI: WAH-1-C_elegans
References [+]
Structure & Sequence [+]
Evolution [+]
Information from other databases [+]