UNC-51 (Caenorhabditis elegans)
Description [+]
- Synonyms: UNC-51
- Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
- Short gene description: unc-51 encodes a serine/threonine protein kinase orthologous to Saccharomyces cerevisiae autophagy protein Atg1p and the vertebrate ULK proteins. unc-51 is required for axon outgrowth along the anterior-posterior axis and sex myoblast migration. in regulating axon outgrowth, UNC-51 functions together with the VAB-8 kinesin-like protein and UNC-14, both of which physically interact with, and are phosphorylated by, UNC-51, and with the UNC-5 Netrin receptor, whose subcellular localization in neurons is regulated by UNC-51 and UNC-14. in addition, UNC-51 is required for normal dauer morphogenesis of daf-2 mutant animals. UNC-51 is expressed in all C. elegans neurons and in body wall and pharyngeal muscles. in neurons, an UNC-51::GFP fusion protein shows punctate cytoplasmic localization in axons and cell bodies and partial co-localization with UNC-14 and UNC-5. [Source: WormBase]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: UNC-51-C_elegans