PME-1 (Caenorhabditis elegans)
Description [+]
- Synonyms: PME-1
- Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
- Short gene description: pme-1 encodes a poly(ADP-ribose) polymerase (PARP) orthologous to human PARP1 (OMIM:173870). PME-1 has two N-terminal zinc fingers that probably bind DNA, and a C-terminal catalytic domain. PME-1 has PARP activity in vitro, which is blocked by mammalian PARP inhibitors. since these inhibitors also cause embryonic lethality in worms exposed to ionizing radiation, PME-1 is likely to be required in vivo for repairing broken DNA. [Source: WormBase]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: PME-1-C_elegans
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | zf-PARP | 13 | 93 |
PFAM A | PADR1 | 313 | 369 |
PFAM A | WGR | 472 | 557 |
PFAM A | PARP_reg | 586 | 724 |
PFAM A | PARP | 726 | 939 |
Protein sequence [+]
pme-1 | Caenorhabditis elegans | 6239 | length:945
MIHSNEPLPYAIEYAKSGRSNCKTCKKNIALDQLRMSMNRPSTFFDGNMDSWFHYNCFWI
KMIRGRDDINISSIRGVDWLRWEDQEKLRQEIQHFKTASPPTLTPLCSTTTVILSTIKTE
KSLSNRGKCGKCGQNFERGEIKAHNKGKANHFKCFLQEFDKISGTVEDIPGWADYEENFK
IKAVGEYVEALAAKRRSTEPATPASASPTPPEAETPVLSAEGSPESSNKRPASSEIIEID
GEGNPDENDFAKKRRMKKEARLMEVQKKRMKKQSDLLWEYRQIFERMPYTDKISILRENE
QDIPEGHDPTAQVIERLVDNALFGCPIICQTCSNGKIVYNSSCRTYVCTGYATEYSKCTY
ESKNPIRTPFEVSHRLTEKHKLQDIVFNQMSERLYIGEEDGESVVKIDKRKSKGGTRGEQ
FIYAAEAFDSTNNVPIKVGDLTSTNTHIIKKGTVVDAKFALADRCHVFKNEIDGSLYQAT
LSFTDLTQNKNSYYKIQLLKDDQRENYYVFRSWGRVGTEVGGNKHESYSNSNEAILKFQD
VFHEKTKNDWIYRKHFRKMPGMFSYVETDYSEFAQITDTEITPGSKTLLPKSVKEVVMSI
FDVENMKSALKSFEMDVNKMPLGRLSHNQINLAFEVLNDISDLLVKLPIDASRILDFSNK
FYTIIPHNFGMRVPEPIDSFHKIKEKNNMLNALLDIKFAYDQISGGDVPASTSLGIDPVD
INYQKLKCIMEPLQQGCDDWNMIHQYLKNTHGATHDLKVELIDILKLNRDNESSKFKRHI
GNRRLLWHGSGKMNFAGILGQGLRIAPPEAPVSGYMFGKGVYFADMFSKSFFYCRANAKE
EAYLLLCDVALGNVQQLMASKNVSRQTLPAGFQSVQGLGRQCPREIGSYNHPDGYTIPLG
LTYMQLQGKQDVDYHLLYNEFIVYDVDQIQLKYLVRVKMHHARHL
KMIRGRDDINISSIRGVDWLRWEDQEKLRQEIQHFKTASPPTLTPLCSTTTVILSTIKTE
KSLSNRGKCGKCGQNFERGEIKAHNKGKANHFKCFLQEFDKISGTVEDIPGWADYEENFK
IKAVGEYVEALAAKRRSTEPATPASASPTPPEAETPVLSAEGSPESSNKRPASSEIIEID
GEGNPDENDFAKKRRMKKEARLMEVQKKRMKKQSDLLWEYRQIFERMPYTDKISILRENE
QDIPEGHDPTAQVIERLVDNALFGCPIICQTCSNGKIVYNSSCRTYVCTGYATEYSKCTY
ESKNPIRTPFEVSHRLTEKHKLQDIVFNQMSERLYIGEEDGESVVKIDKRKSKGGTRGEQ
FIYAAEAFDSTNNVPIKVGDLTSTNTHIIKKGTVVDAKFALADRCHVFKNEIDGSLYQAT
LSFTDLTQNKNSYYKIQLLKDDQRENYYVFRSWGRVGTEVGGNKHESYSNSNEAILKFQD
VFHEKTKNDWIYRKHFRKMPGMFSYVETDYSEFAQITDTEITPGSKTLLPKSVKEVVMSI
FDVENMKSALKSFEMDVNKMPLGRLSHNQINLAFEVLNDISDLLVKLPIDASRILDFSNK
FYTIIPHNFGMRVPEPIDSFHKIKEKNNMLNALLDIKFAYDQISGGDVPASTSLGIDPVD
INYQKLKCIMEPLQQGCDDWNMIHQYLKNTHGATHDLKVELIDILKLNRDNESSKFKRHI
GNRRLLWHGSGKMNFAGILGQGLRIAPPEAPVSGYMFGKGVYFADMFSKSFFYCRANAKE
EAYLLLCDVALGNVQQLMASKNVSRQTLPAGFQSVQGLGRQCPREIGSYNHPDGYTIPLG
LTYMQLQGKQDVDYHLLYNEFIVYDVDQIQLKYLVRVKMHHARHL
Structure links:
Evolution [+]
Explore tree at phylomeDB:   Click here.
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KEGG Pathways [+]
Information from other databases [+]
- Gene info from Wormbase [?] Y71F9AL.18
- Ensembl genome browser [?] : Y71F9AL.18
- Expression info from Arrayexpress [?] : Y71F9AL.18
- Protein expression from Protein Atlas: [?] Y71F9AL.18
Click on [?] for more information.