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PME-5   (Caenorhabditis elegans)

Description [+]
  • Synonyms: PME-5
  • Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
  • Short gene description: pme-5 encodes an ortholog of human tankyrase 1 (TNKS. OMIM:603303) and tankyrase 2 (TNKS2. OMIM: 607128), but structurally is more similar to the ADPRT-3 tankyrase of Dictyostelium discoideum. as in other tankyrases, PME-5's N-terminal region has extensive ankyrin domains, probably binding other proteins, and its C-terminal region has poly (ADP-ribose) polymerase (PARP) regulatory and catalytic domains. PME-5 is predicted to be nuclear. X-ray-induced apoptosis of germ cells is slightly increased in pme-5(RNAi) animals. DNA damage induces pme-5 expression, and this induction absolutely requires HUS-1. [Source: WormBase]
  • Family: Null
  • Process:
  • Pathways:
  • Criteria: homology search
  • Curator comment: Null
  • WIKI: PME-5-C_elegans
Structure & Sequence [+]
Evolution [+]
Information from other databases [+]