PME-5 (Caenorhabditis elegans)
Description [+]
- Synonyms: PME-5
- Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
- Short gene description: pme-5 encodes an ortholog of human tankyrase 1 (TNKS. OMIM:603303) and tankyrase 2 (TNKS2. OMIM: 607128), but structurally is more similar to the ADPRT-3 tankyrase of Dictyostelium discoideum. as in other tankyrases, PME-5's N-terminal region has extensive ankyrin domains, probably binding other proteins, and its C-terminal region has poly (ADP-ribose) polymerase (PARP) regulatory and catalytic domains. PME-5 is predicted to be nuclear. X-ray-induced apoptosis of germ cells is slightly increased in pme-5(RNAi) animals. DNA damage induces pme-5 expression, and this induction absolutely requires HUS-1. [Source: WormBase]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: PME-5-C_elegans
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | Ank | 1171 | 1203 |
PFAM A | WGR | 1795 | 1883 |
PFAM A | PARP | 2069 | 2276 |
Protein sequence [+]
pme-5 | Caenorhabditis elegans | 6239 | length:2276
MARRVNKKKSPVKAARKIDGQIGRRVVDGVRAKSSRQRHQAVLYQAPTPTVIRRKTTKTA
IVKKTVVVVKKGGKVVKKSSKTGQKVKAVKAPKVKAPSKKGNDRLTPRVITEYQENPFFY
DPQVPEYISASVYHRWITRAVRNGNMKEIKDYYKSKKCQKSAIYTSFAYSFDTSACDEAL
RQDIKFATEFFKMNNKMEVDNSYHPGKEPNLLQKKTTGRKNYYMLGRHTRQIEMGRGGKE
GNNALLNYDTRTDEPNPLTKLIEDNVTYTKLYQLCKIPDGPIVEHHIEMHFVTAVRMGHR
DLASALAQGPVKMHCNDLHRATLKDQKLPAKILPVSVAKKAYMNKNITPLHTAAISNSTH
MLEAMRAVYPTINIPDQDNWYTMHYAACAPGTAPMEFLLKNGGSVTMLTKQTETPLHVAA
RAGRAVNCTFLMKEMLDLEKGDDGESTIRADRSIINARTRSGNSALHLAVLRNNLDVVDA
LLAEPTIVVDNPTSTGQNRLTPLMMACGKGYLEMAKKLVEKGALVEGKDKKKRTPLIHAM
LNGQIHTAAFLLAKGASLTLADSSGNTAAHYAAAYGFLDCLKLLASIDDNILSEPNDWQL
YPLSVAYLKGHYGIVTWLLEGPHKDKANINAKDNNGATLLSNLLSYADETMHKELLSQIE
YLVARKADASLADSSGQTPLHLFSMQRIILKGSGEAAENDAMRMTLDNYKKCFNTLIKAG
AKVDVYDHEDNTPLHYALTNGNLMLFNLMLDKVANKRNLFEKWANHQNFLHEILALPMKV
YGDQVLWKGETLTKPAYDVLPILKELHENLPDLFEKWISEVNKAGYSPIVEAIKQYQALA
ANKKLRGEADQNGNPGFGNAIARGRVHNQFGRDRMNQSQAPHCDSYELKTFISTVNELFE
WVIRLGPFQLTQKYINSENSAAVTLANLAMSIPIECGRHQQNQLALFKILIKLSKEFNKV
DEFLTQKNEKDDVLIVQAIMFDKPNVVELILDTASEMHLIHGTHNAIKENELEVVVHKTI
IMYMIEMRMWELIPKVNASSEFWKSKDAKGNSVWHYAARVNSHKTVGLFKMIESKGVRRE
TNDDGRSVLHVATLACDGSADSVLEPIAWLSTRCPIDAVDKFNRTALHYAFGNENDFKEG
NVPFGESDPIAVVSLLSSLIRPEQIEIADVNGNTILHLAAIKNSTICLMTLIRKKCHVDL
KNKDGNTPLALAVHHGRQSSALTLIQANADVTEKIFVPALKPTSDFDQNSSGTEAEKFWK
WHGKEKKVLEDLHTTIPASVVSKGGSWEAMVYVLLDVLGQNTGSMAQLTDAALRRGQLNL
ANQLLKSIEALIDGAVLNSSYDLLDTFAEKCFGALTSEETIEKTVLNRIILTRGLGLKQP
ETMKIIRTALQNGNWNLLNFLKSEMGTAWKNQKIETPTENPIRSLLIYMNEKSVSSEAIG
FLEELRQMRGVNIDALCQLEIPGKFKKILDYGLIPPISFAVLQENPNMIRALRNAGASLK
TQDDYGRTPLMYAIMTNNRSVVDAIVGDGKLAVVLHKQKAVATGPRCVAVPMRFGATSRA
FIPAAAFASVPARVESDEEEEDNSGSESGEDGAASENKSEHGSENGESGNGSDDEDDDDD
DSSPPPAKKSRIAKEAAGPSTGPKRKKLVITDPSLFSARDHKENNPLHYFIEPLAWENVE
LLGDLAAANKTAIVQCLIDKRSPNPIELAAMKMNRRMKSEMLKIVKNAAFPRPIKETKLT
LQQVHIEPLSDVDEDAAKFLAKWVEEKDKKKTSEAPKPHKSSTYSTNGLVSFCDETQQYF
DVLMNKTDLMYGRCGFHNFYRMQIIKRRDAELFILFTNWGRIGSGMGEFQTTPFNSLELA
AKEFKSIFKSKSGNEWAPLANFRDMPKKYRLVETDSTPTSLAEIELTWKKNTEKDPIRRM
IADISDAKTLKTYASQVQMYGGSSQPFGRFTKENIEKAKLVLDKLEKNANRIKQMVEAQT
GVVESNLLDAYITTSELSGDYYSLIPSGEYEFSNLTRLDNVEEIARHRARLNRCQEIETA
TRLLCAAEFRQDLDRVDYIRSAIQCEYRLETPDSDISQRLLQWIHNSGGKQAKVKMILEI
SPMLSTEKFEPFVNDDNQKFLWHGTKATNLMSILKNGFLIDPPSACKNGNLFGSGIYLAD
SFEKSTHYCQPSAGGINYMLVCQTALGKVRTLDTIPYHYMNQSSSSAEKYEDTLHYIGDR
FPAGSLTNDGVGMPLLPLRKRDPIQGSNYGFGTLDFSEYIVRNPNRVLPKYIVMYK
IVKKTVVVVKKGGKVVKKSSKTGQKVKAVKAPKVKAPSKKGNDRLTPRVITEYQENPFFY
DPQVPEYISASVYHRWITRAVRNGNMKEIKDYYKSKKCQKSAIYTSFAYSFDTSACDEAL
RQDIKFATEFFKMNNKMEVDNSYHPGKEPNLLQKKTTGRKNYYMLGRHTRQIEMGRGGKE
GNNALLNYDTRTDEPNPLTKLIEDNVTYTKLYQLCKIPDGPIVEHHIEMHFVTAVRMGHR
DLASALAQGPVKMHCNDLHRATLKDQKLPAKILPVSVAKKAYMNKNITPLHTAAISNSTH
MLEAMRAVYPTINIPDQDNWYTMHYAACAPGTAPMEFLLKNGGSVTMLTKQTETPLHVAA
RAGRAVNCTFLMKEMLDLEKGDDGESTIRADRSIINARTRSGNSALHLAVLRNNLDVVDA
LLAEPTIVVDNPTSTGQNRLTPLMMACGKGYLEMAKKLVEKGALVEGKDKKKRTPLIHAM
LNGQIHTAAFLLAKGASLTLADSSGNTAAHYAAAYGFLDCLKLLASIDDNILSEPNDWQL
YPLSVAYLKGHYGIVTWLLEGPHKDKANINAKDNNGATLLSNLLSYADETMHKELLSQIE
YLVARKADASLADSSGQTPLHLFSMQRIILKGSGEAAENDAMRMTLDNYKKCFNTLIKAG
AKVDVYDHEDNTPLHYALTNGNLMLFNLMLDKVANKRNLFEKWANHQNFLHEILALPMKV
YGDQVLWKGETLTKPAYDVLPILKELHENLPDLFEKWISEVNKAGYSPIVEAIKQYQALA
ANKKLRGEADQNGNPGFGNAIARGRVHNQFGRDRMNQSQAPHCDSYELKTFISTVNELFE
WVIRLGPFQLTQKYINSENSAAVTLANLAMSIPIECGRHQQNQLALFKILIKLSKEFNKV
DEFLTQKNEKDDVLIVQAIMFDKPNVVELILDTASEMHLIHGTHNAIKENELEVVVHKTI
IMYMIEMRMWELIPKVNASSEFWKSKDAKGNSVWHYAARVNSHKTVGLFKMIESKGVRRE
TNDDGRSVLHVATLACDGSADSVLEPIAWLSTRCPIDAVDKFNRTALHYAFGNENDFKEG
NVPFGESDPIAVVSLLSSLIRPEQIEIADVNGNTILHLAAIKNSTICLMTLIRKKCHVDL
KNKDGNTPLALAVHHGRQSSALTLIQANADVTEKIFVPALKPTSDFDQNSSGTEAEKFWK
WHGKEKKVLEDLHTTIPASVVSKGGSWEAMVYVLLDVLGQNTGSMAQLTDAALRRGQLNL
ANQLLKSIEALIDGAVLNSSYDLLDTFAEKCFGALTSEETIEKTVLNRIILTRGLGLKQP
ETMKIIRTALQNGNWNLLNFLKSEMGTAWKNQKIETPTENPIRSLLIYMNEKSVSSEAIG
FLEELRQMRGVNIDALCQLEIPGKFKKILDYGLIPPISFAVLQENPNMIRALRNAGASLK
TQDDYGRTPLMYAIMTNNRSVVDAIVGDGKLAVVLHKQKAVATGPRCVAVPMRFGATSRA
FIPAAAFASVPARVESDEEEEDNSGSESGEDGAASENKSEHGSENGESGNGSDDEDDDDD
DSSPPPAKKSRIAKEAAGPSTGPKRKKLVITDPSLFSARDHKENNPLHYFIEPLAWENVE
LLGDLAAANKTAIVQCLIDKRSPNPIELAAMKMNRRMKSEMLKIVKNAAFPRPIKETKLT
LQQVHIEPLSDVDEDAAKFLAKWVEEKDKKKTSEAPKPHKSSTYSTNGLVSFCDETQQYF
DVLMNKTDLMYGRCGFHNFYRMQIIKRRDAELFILFTNWGRIGSGMGEFQTTPFNSLELA
AKEFKSIFKSKSGNEWAPLANFRDMPKKYRLVETDSTPTSLAEIELTWKKNTEKDPIRRM
IADISDAKTLKTYASQVQMYGGSSQPFGRFTKENIEKAKLVLDKLEKNANRIKQMVEAQT
GVVESNLLDAYITTSELSGDYYSLIPSGEYEFSNLTRLDNVEEIARHRARLNRCQEIETA
TRLLCAAEFRQDLDRVDYIRSAIQCEYRLETPDSDISQRLLQWIHNSGGKQAKVKMILEI
SPMLSTEKFEPFVNDDNQKFLWHGTKATNLMSILKNGFLIDPPSACKNGNLFGSGIYLAD
SFEKSTHYCQPSAGGINYMLVCQTALGKVRTLDTIPYHYMNQSSSSAEKYEDTLHYIGDR
FPAGSLTNDGVGMPLLPLRKRDPIQGSNYGFGTLDFSEYIVRNPNRVLPKYIVMYK
Structure links:
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Information from other databases [+]
- entrezgene: 178623
- refseq_dna: NM_071000
- refseq_dna: NR_003180
- refseq_dna: NM_001029135
- refseq_peptide: NP_503401
- refseq_peptide: NP_001024306
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