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CNX-1   (Caenorhabditis elegans)

Description [+]
  • Synonyms: CNX-1
  • Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
  • Short gene description: cnx-1 encodes the C. elegans ortholog of calnexin, a type I Ca2+-binding integral membrane protein of the endoplasmic reticulum (ER). CNX-1 binds calcium and is predicted to function as a molecular chaperone required for glycoprotein folding and maturation as well as regulation of intracellular calcium homeostasis. in C. elegans, cnx-1 activity is required at 25 degrees C for wild-type levels of fertility and normal embryonic and larval development. cnx-1 activity is also required for maintaining viability in response to ER stress. in addition, cnx-1(RNAi) can suppress necrotic-like cell death induced by hyperactivated MEC-4 and DEG-1 ion channels, suggesting that CNX-1 also plays a role in regulating necrotic cell death. CNX-1 expression is first detected ubiquitously in the early embryo, with expression then becoming restricted to embryonic head and tail regions. post-embryonic expression is seen in the excretory cell, head and tail neurons, spermatheca, intestine, germ cells, and spicules in the male tail. antibody staining of early embryos indicates that CNX-1 localizes to the endoplasmic reticulum. in regulating reproduction at 25 degrees C, cnx-1 functions redundantly with crt-1, which encodes calreticulin, an additional Ca2+-binding ER chaperone protein. [Source: WormBase]
  • Family: Null
  • Process:
  • Pathways:
  • Criteria: homology search
  • Curator comment: Null
  • WIKI: CNX-1-C_elegans
Structure & Sequence [+]
Evolution [+]
Information from other databases [+]