LCK (Canis lupus familiaris)
Description [+]
- Synonyms: LCK
- Species: Canis lupus familiaris
- Short gene description: Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)(Lymphocyte cell-specific protein-tyrosine kinase)(p56-LCK)(LSK)(T cell-specific protein-tyrosine kinase) [Source:UniProtKB/Swiss-Prot;Acc:P06239]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: LCK-C_familiaris
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | SH3_1 | 64 | 119 |
PFAM A | SH3_2 | 65 | 119 |
PFAM A | SH2 | 127 | 209 |
PFAM A | Pkinase | 245 | 497 |
PFAM A | Pkinase_Tyr | 245 | 494 |
Protein sequence [+]
LCK | Canis lupus familiaris | 9615 | length:509
MGCSCSSNPEDDWMENIDVCENCHYPIVPLDGKATLPMRNGSDVRDPLVIYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILERNGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDKGGFYISPRITFPGLHELVRHYTNSSDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPPGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMMLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILERNGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDKGGFYISPRITFPGLHELVRHYTNSSDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPPGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMMLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
Structure links:
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0006468 | protein amino acid phosphorylation | biological_proccess | IEA |
GO:0046777 | protein amino acid autophosphorylation | biological_proccess | IEA |
GO:0007166 | cell surface receptor linked signal transduction | biological_proccess | IEA |
GO:0018108 | peptidyl-tyrosine phosphorylation | biological_proccess | IEA |
GO:0050853 | B cell receptor signaling pathway | biological_proccess | IEA |
GO:0045588 | positive regulation of gamma-delta T cell differentiation | biological_proccess | IEA |
GO:0050856 | regulation of T cell receptor signaling pathway | biological_proccess | IEA |
GO:0051209 | release of sequestered calcium ion into cytosol | biological_proccess | IEA |
GO:0004672 | protein kinase activity | mollecular_function | IEA |
GO:0005524 | ATP binding | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IEA |
GO:0004713 | protein tyrosine kinase activity | mollecular_function | IEA |
GO:0004674 | protein serine/threonine kinase activity | mollecular_function | IEA |
Check GO Evidence Codes here
KEGG Pathways [+]
Information from other databases [+]
- Ensembl genome browser [?] : ENSCAFG00000010625
- Expression info from Arrayexpress [?] : ENSCAFG00000010625
- Protein expression from Protein Atlas: [?] ENSCAFG00000010625
- entrezgene: 478151
Click on [?] for more information.