NP_001002950.1 (Canis lupus familiaris)
Description [+]
- Synonyms: NP_001002950.1
- Species: Canis lupus familiaris
- Short gene description: Toll-like receptor4 protein [Source:RefSeq_peptide;Acc:NP_001002950]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: NP_001002950.1-C_familiaris
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | TIR | 677 | 815 |
Protein sequence [+]
NP_001002950.1 | Canis lupus familiaris | 9615 | length:842
MMSPTRLVGILIPAMAFLSCLRPESWDPCMQVVANTTYQCMELNLSKIPNNIPTSTEKLD
LSFNPLRHLGSHCFSNFPKLQVLDLSRCEIQVIEDDAYQGLNHLSILILTGNPIQRLFPR
AFSGLSSLKTLVAKETKLTSLEDFPIGHLKTLKELNVAHNLIHSFKLPAYFSNMPNLENV
DLSNNKIQNIYREDLQVLHHMPLLNLSLDLSLNPLYFIQPGSFKEIKLHKLTLRSNFNST
DVMKTFIQGLAGLKINQLVLGEFKNERKLESFDNSLLEGLCNLTIEKFRIAYFDSFSKDT
TNLFNQLVNISAISLAHLYLDTPKYLPKNLRWQRLEIVNCNLEQFPAWELDSLKEFVLTS
NKGMNTFADMKMESLEFLDLSRNRLSFKTCCSHSDFGTTRLKHLDLSFNEIITMSSNFLG
LEQLEYLDLQHSSLKQASDFSVFLSLRNLRYLDISYTRTEVAFQGIFDGLVSLEVLKMAD
NSFPDNSLPNIFKGLTNLTILDLSRCHLERVSQESFVSLPKLQEINMSHNSLLSLDTLAY
EPLLSLQILDCSFNRIVAFKEQGQQHFPSNLVSLNLTRNNFACDCEHQSFLQWVKDHRQL
LVEVEQMVCAKPLDMKDMPLLSFRNATCQRSKTIISVSVFTVLMVSLVAVLAYKFYFHLM
LLAGCKRYNRGESTYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIA
ANIIQEGFYKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKSLL
RQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKPWSPEGTEDAPQNLQVDAST
KS
LSFNPLRHLGSHCFSNFPKLQVLDLSRCEIQVIEDDAYQGLNHLSILILTGNPIQRLFPR
AFSGLSSLKTLVAKETKLTSLEDFPIGHLKTLKELNVAHNLIHSFKLPAYFSNMPNLENV
DLSNNKIQNIYREDLQVLHHMPLLNLSLDLSLNPLYFIQPGSFKEIKLHKLTLRSNFNST
DVMKTFIQGLAGLKINQLVLGEFKNERKLESFDNSLLEGLCNLTIEKFRIAYFDSFSKDT
TNLFNQLVNISAISLAHLYLDTPKYLPKNLRWQRLEIVNCNLEQFPAWELDSLKEFVLTS
NKGMNTFADMKMESLEFLDLSRNRLSFKTCCSHSDFGTTRLKHLDLSFNEIITMSSNFLG
LEQLEYLDLQHSSLKQASDFSVFLSLRNLRYLDISYTRTEVAFQGIFDGLVSLEVLKMAD
NSFPDNSLPNIFKGLTNLTILDLSRCHLERVSQESFVSLPKLQEINMSHNSLLSLDTLAY
EPLLSLQILDCSFNRIVAFKEQGQQHFPSNLVSLNLTRNNFACDCEHQSFLQWVKDHRQL
LVEVEQMVCAKPLDMKDMPLLSFRNATCQRSKTIISVSVFTVLMVSLVAVLAYKFYFHLM
LLAGCKRYNRGESTYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIA
ANIIQEGFYKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKSLL
RQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKPWSPEGTEDAPQNLQVDAST
KS
Structure links:
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0007165 | signal transduction | biological_proccess | IEA |
GO:0045087 | innate immune response | biological_proccess | IEA |
GO:0009401 | phosphoenolpyruvate-dependent sugar phosphotransferase system | biological_proccess | IEA |
GO:0045084 | positive regulation of interleukin-12 biosynthetic process | biological_proccess | IEA |
GO:0042116 | macrophage activation | biological_proccess | IEA |
GO:0032497 | detection of lipopolysaccharide | biological_proccess | IEA |
GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process | biological_proccess | IEA |
GO:0045416 | positive regulation of interleukin-8 biosynthetic process | biological_proccess | IEA |
GO:0032760 | positive regulation of tumor necrosis factor production | biological_proccess | IEA |
GO:0032496 | response to lipopolysaccharide | biological_proccess | IEA |
GO:0032755 | positive regulation of interleukin-6 production | biological_proccess | IEA |
GO:0032874 | positive regulation of stress-activated MAPK cascade | biological_proccess | IEA |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | biological_proccess | IEA |
GO:0046330 | positive regulation of JNK cascade | biological_proccess | IEA |
GO:0070374 | positive regulation of ERK1 and ERK2 cascade | biological_proccess | IEA |
GO:0032609 | interferon-gamma production | biological_proccess | IEA |
GO:0009617 | response to bacterium | biological_proccess | IEA |
GO:0010572 | positive regulation of platelet activation | biological_proccess | IEA |
GO:0002537 | production of nitric oxide during acute inflammatory response | biological_proccess | IEA |
GO:0070430 | positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway | biological_proccess | IEA |
GO:0070434 | positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway | biological_proccess | IEA |
GO:0004872 | receptor activity | mollecular_function | IEA |
GO:0004888 | transmembrane receptor activity | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IEA |
GO:0005351 | sugar:hydrogen symporter activity | mollecular_function | IEA |
GO:0001875 | lipopolysaccharide receptor activity | mollecular_function | IEA |
GO:0016020 | membrane | cell_component | IEA |
GO:0016021 | integral to membrane | cell_component | IEA |
GO:0031224 | intrinsic to membrane | cell_component | IEA |
GO:0005887 | integral to plasma membrane | cell_component | IEA |
GO:0009897 | external side of plasma membrane | cell_component | IEA |
GO:0048471 | perinuclear region of cytoplasm | cell_component | IEA |
Check GO Evidence Codes here
KEGG Pathways [+]
Information from other databases [+]
- Ensembl genome browser [?] : ENSCAFG00000003518
- Expression info from Arrayexpress [?] : ENSCAFG00000003518
- Protein expression from Protein Atlas: [?] ENSCAFG00000003518
- entrezgene: 403417
- refseq_dna: NM_001002950
- refseq_peptide: NP_001002950
Click on [?] for more information.