WGN (Drosophila melanogaster)
Description [+]
- Synonyms: WGN, WENGEN, TNFR SUPERFAMILY PROTEIN WENGEN, VADER
- Species: Metazoa;Bilateria;Ecdysozoa;Arthropoda;Hexapoda; Drosophila melanogaster
- Short gene description: NA
- Family: death receptor
- Process: cell death (other),
- Pathways: TNF/NF-kappaB signaling,
- Criteria: manually curated
- Curator comment:
- WIKI: WGN-D_melanogaster
References [+]
- Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling.
- Kanda H, Igaki T, Kanuka H, Yagi T, Miura M
- We identified Wengen, the first member of the Drosophila tumor necrosis factor receptor (TNFR) superfamily. Wengen is a type III membrane protein with conserved cysteine-rich residues (TNFR homology domain) in the extracellular domain, a hallmark of the TNFR superfamily. wengen mRNA is expressed at all stages of Drosophila development. The small-eye phenotype caused by an eye-specific overexpression of a Drosophila TNF superfamily ligand, Eiger, was dramatically suppressed by down-regulation of Wengen using RNA interference. In addition, Wengen and Eiger physically interacted with each other through their TNFR homology domain and TNF homology domain, respectively. These results suggest that Wengen can act as a component of a functional receptor for Eiger. Our identification of Wengen and further genetic analysis should provide increased understanding of the evolutionarily conserved roles of TNF/TNFR superfamily proteins in normal development, as well as in some pathophysiological conditions. J Biol Chem. 2002 Aug 9;277(32):28372-5. Epub 2002 Jun 25.
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | TNFR_c6 | 100 | 137 |
Protein sequence [+]
wgn | Drosophila melanogaster | 7227 | length:343
MMPPRLPGGHGGAMRSRSSSSGHHLNTTFHKRRRRRQQHHIGGSHISISHGSYLALLLLS
TTCSLVATSASSSSSAANTDIAPPDPPPVSQVSIASSSPCAPQHWWDSQRDRCTPCTRCQ
GEMIPLRPCQLHTDTICGSIYDLKIDWVVLAKTEPNWKERRKSSEYEHFEHNAPLQHLTH
EQLQQLHEEAAAAWVLDWQTGVLYVAVLTCLVFFSVAACILIHHMRQWRRMERRLDQDVE
ELSTKLMAKLAEVQSLDGGTFFIGNADALRGLPASAATTHPATTQSGIFQPQHVLLPEKR
GKHQERRILKTLQPGNVYIEESNAGLGGMGVGLGVRGCSGLKG
TTCSLVATSASSSSSAANTDIAPPDPPPVSQVSIASSSPCAPQHWWDSQRDRCTPCTRCQ
GEMIPLRPCQLHTDTICGSIYDLKIDWVVLAKTEPNWKERRKSSEYEHFEHNAPLQHLTH
EQLQQLHEEAAAAWVLDWQTGVLYVAVLTCLVFFSVAACILIHHMRQWRRMERRLDQDVE
ELSTKLMAKLAEVQSLDGGTFFIGNADALRGLPASAATTHPATTQSGIFQPQHVLLPEKR
GKHQERRILKTLQPGNVYIEESNAGLGGMGVGLGVRGCSGLKG
Structure links:
- Smartdomain prediction information: SM00208
Evolution [+]
View protein alignment and tree with Jalview:  
Explore tree at phylomeDB:   Click here.
Homologs list [+]
Name | Relationship | Species |
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Information from other databases [+]
- Gene info from FyBase [?] FBgn0030941
- Ensembl genome browser [?] : FBgn0030941
- Expression info from Arrayexpress [?] : FBgn0030941
- Protein expression from Protein Atlas: [?] FBgn0030941
Click on [?] for more information.