W (Drosophila melanogaster)
Description [+]
- Synonyms: W, CELL DEATH PROTEIN W, PROTEIN HEAD INVOLUTION DEFECTIVE, PROTEIN WRINKLED, HID
- Species: Metazoa;Bilateria;Ecdysozoa;Arthropoda;Hexapoda; Drosophila melanogaster
- Short gene description: NA
- Family: IAP antagonist
- Process: apoptosis,
- Pathways:
- Criteria: manually curated
- Curator comment:
- WIKI: W-D_melanogaster
References [+]
- The head involution defective gene of Drosophila melanogaster functions in programmed cell death.
- Grether ME, Abrams JM, Agapite J, White K, Steller H
- Deletions of chromosomal region, 75C1,2 block virtually all programmed cell death (PCD) in the Drosophila embryo. We have identified a gene previously in this interval, reaper (rpr), which encodes an important regulator of PCD. Here we report the isolation of a second gene in this region, head involution defective (hid), which plays a similar role in PCD. hid mutant embryos have decreased levels of cell death and contain extra cells in the head. We have cloned the hid gene and find that its expression is sufficient to induce PCD in cell death defective mutants. The hid gene appears to encode a novel 410-amino-acid protein, and its mRNA is expressed in regions of the embryo where cell death occurs. Ectopic expression of hid in the Drosophila retina results in eye ablation. This phenotype can be suppressed completely by expression of the anti-apoptotic p35 protein from baculovirus, indicating that p35 may act genetically downstream from hid. Genes Dev. 1995 Jul 15;9(14):1694-708.
Structure & Sequence [+]
Protein sequence [+]
W | Drosophila melanogaster | 7227 | length:410
MAVPFYLPEGGADDVASSSSGASGNSSPHNHPLPSSASSSVSSSGVSSASASSASSSSSA
SSDGASSAASQSPNTTTSSATQTPMQSPLPTDQVLYALYEWVRMYQSQQSAPQIFQYPPP
SPSCNFTGGDVFFPHGHPNPNSNPHPRTPRTSVSFSSGEEYNFFRQQQPQPHPSYPAPST
PQPMPPQSAPPMHCSHSYPQQSAHMMPHHSAPFGMGGTYYAGYTPPPTPNTASAGTSSSS
AAFGWHGHPHSPFTSTSTPLSAPVAPKMRLQRSQSDAARRKRLTSTGEDEREYQSDHEAT
WDEFGDRYDNFTAGRERLQEFNGRIPPRKKKSSNSHSSSSNNPVCHTDSQPGGTSQAESG
AIHGHISQQRQVERERQKAKAEKKKPQSFTWPTVVTVFVLAMGCGFFAAR
SSDGASSAASQSPNTTTSSATQTPMQSPLPTDQVLYALYEWVRMYQSQQSAPQIFQYPPP
SPSCNFTGGDVFFPHGHPNPNSNPHPRTPRTSVSFSSGEEYNFFRQQQPQPHPSYPAPST
PQPMPPQSAPPMHCSHSYPQQSAHMMPHHSAPFGMGGTYYAGYTPPPTPNTASAGTSSSS
AAFGWHGHPHSPFTSTSTPLSAPVAPKMRLQRSQSDAARRKRLTSTGEDEREYQSDHEAT
WDEFGDRYDNFTAGRERLQEFNGRIPPRKKKSSNSHSSSSNNPVCHTDSQPGGTSQAESG
AIHGHISQQRQVERERQKAKAEKKKPQSFTWPTVVTVFVLAMGCGFFAAR
Evolution [+]
View protein alignment and tree with Jalview:
Explore tree at phylomeDB: Click here.
Homologs list [+]
| Name | Relationship | Species |
|---|
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Gene Ontology [+]
| GO id | Name | Ontology type | Evidence |
|---|---|---|---|
| GO:0006468 | protein amino acid phosphorylation | biological_proccess | IEA |
| GO:0007156 | homophilic cell adhesion | biological_proccess | IEA |
| GO:0000166 | nucleotide binding | mollecular_function | IEA |
| GO:0004672 | protein kinase activity | mollecular_function | IEA |
| GO:0004713 | protein tyrosine kinase activity | mollecular_function | IEA |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | mollecular_function | IEA |
| GO:0004872 | receptor activity | mollecular_function | IEA |
| GO:0005509 | calcium ion binding | mollecular_function | IEA |
| GO:0005524 | ATP binding | mollecular_function | IEA |
| GO:0016301 | kinase activity | mollecular_function | IEA |
| GO:0016740 | transferase activity | mollecular_function | IEA |
| GO:0004674 | protein serine/threonine kinase activity | mollecular_function | IEA |
| GO:0005575 | cellular_component | cell_component | ND |
| GO:0016020 | membrane | cell_component | IEA |
| GO:0016021 | integral to membrane | cell_component | IEA |
Check GO Evidence Codes here
Information from other databases [+]
- Gene info from FyBase [?] FBgn0003997
- Ensembl genome browser [?] : FBgn0003997
- Expression info from Arrayexpress [?] : FBgn0003997
- Protein expression from Protein Atlas: [?] FBgn0003997
Click on [?] for more information.
