DREAM (Drosophila melanogaster)

Description [+]

Synonyms: DREAM, STRICA
Species: Metazoa;Bilateria;Ecdysozoa;Arthropoda;Hexapoda; Drosophila melanogaster
Short gene description: NA
Family: CASPASE
Process: apoptosis,
Pathways:
Criteria: manually curated
Curator comment:
WIKI: DREAM-D_melanogaster

References [+]

STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2.
Doumanis J, Quinn L, Richardson H, Kumar S
The recently published genome sequence of Drosophila melanogaster predicts seven caspases in the fly. Five of these caspases have been previously characterised. Here, we describe the Drosophila caspase, STRICA. STRICA is a caspase with a long amino-terminal prodomain that lacks any caspase recruitment domain or death effector domain. Instead, the prodomain of STRICA consists of unique serine/threonine stretches. Low levels of strica expression were detected in embryos, larvae, pupae and adult animals. STRICA is a cytoplasmic protein that, upon overexpression, caused apoptosis in cultured Drosophila SL2 cells that was partially suppressed by DIAP1. Interestingly, unlike other fly caspases, STRICA showed physical association with DIAP2, in cotransfection experiments. These results suggest that STRICA may have a unique cellular function. Cell Death Differ. 2001 Apr;8(4):387-94.

Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery.
Leulier F, Ribeiro PS, Palmer E, Tenev T, Takahashi K, Robertson D, Zachariou A, Pichaud F, Ueda R, Meier P
Despite the identification of numerous key players of the cell death machinery, little is known about their physiological role. Using RNA interference (RNAi) in vivo, we have studied the requirement of all Drosophila caspases and caspase-adaptors in different paradigms of apoptosis. Of the seven caspases, Dronc, drICE, Strica and Decay are rate limiting for apoptosis. Surprisingly, Hid-mediated apoptosis requires a broader range of caspases than apoptosis initiated by loss of the caspase inhibitor DIAP1, suggesting that Hid causes apoptosis not only by antagonizing DIAP1 but also by activating DIAP1-independent caspase cascades. While Hid killing requires Strica, Decay, Dronc/Dark and drICE, apoptosis triggered by DIAP1 depletion merely relied upon Dronc/Dark and drICE. Furthermore, we found that overexpression of DIAP2 can rescue diap1-RNAi-mediated apoptosis, suggesting that DIAP2 regulates caspases directly. Consistently, we show that DIAP2 binds active drICE. Since DIAP2 associates with Hid, we propose a model whereby Hid co-ordinately targets both DIAP1 and DIAP2 to unleash drICE. Cell Death Differ. 2006 Oct;13(10):1663-74. Epub 2006 Feb 17.

Structure & Sequence [+]

Source	Domain Name	Start	End
PFAM A	Peptidase_C14	313	523

Evolution [+]

Name	Relationship	Species
A_aegypti_AAEL005956-PA	orthology	Aedes
A_aegypti_AAEL005963-PA	orthology	Aedes
CASPS9	orthology	Anopheles
CASPS12	orthology	Anopheles
CASP14	orthology	Dog
CASP1_HORSE	orthology	Horse
M_domestica_ENSMODP00000034020	orthology	Monodelphis
Caspase-14	orthology	Mouse
CASP14	orthology	Rabbit
A_aegypti_AAEL003444-PA	paralogy	Aedes
A_aegypti_AAEL014348-PA	paralogy	Aedes
A_aegypti_AAEL014658-PA	paralogy	Aedes
CASPS7	paralogy	Anopheles
CASPS6	paralogy	Anopheles
CASPS5	paralogy	Anopheles
CASPS8	paralogy	Anopheles
CASPS1	paralogy	Anopheles
CASPS2	paralogy	Anopheles
CASPS4	paralogy	Anopheles
CASPS3	paralogy	Anopheles
CASPS14	paralogy	Anopheles
Q90WU0_CHICK	paralogy	Chicken
CASP10	paralogy	Chicken
NP_001038154.1	paralogy	Chicken
NP_989923.1	paralogy	Chicken
CASP7	paralogy	Chicken
NP_990056.1	paralogy	Chicken
NP_990057.1	paralogy	Chicken
CASP8	paralogy	Chimpanzee
CASP6	paralogy	Chimpanzee
CASP3_PANTR	paralogy	Chimpanzee
CASP9	paralogy	Chimpanzee
CASP7	paralogy	Chimpanzee
C_intestinalis_ENSCINP00000011493	paralogy	Ciona
C_intestinalis_ENSCINP00000011503	paralogy	Ciona
C_intestinalis_ENSCINP00000024485	paralogy	Ciona
C_intestinalis_ENSCINP00000025743	paralogy	Ciona
C_intestinalis_ENSCINP00000025905	paralogy	Ciona
C_intestinalis_ENSCINP00000028692	paralogy	Ciona
NP_001039435.1	paralogy	Cow
IPI00704513.4	paralogy	Cow
IPI00689801.3	paralogy	Cow
CASP6_BOVIN	paralogy	Cow
CASP3_BOVIN	paralogy	Cow
CASP7	paralogy	Dog
CASP6	paralogy	Dog
Q38JA9_CANFA	paralogy	Dog
Q45T68_CANFA	paralogy	Dog
CASP3_CANFA	paralogy	Dog
Dcp-1	paralogy	Fly
decay	paralogy	Fly
Ice	paralogy	Fly
Damm	paralogy	Fly
CASP6	paralogy	Fugu
T_rubripes_ENSTRUP00000024164	paralogy	Fugu
T_rubripes_ENSTRUP00000024467	paralogy	Fugu
CASP7	paralogy	Fugu
NP_001027871.1	paralogy	Fugu
CASP9	paralogy	Fugu
CASP9	paralogy	Gasterosteus
CASP7	paralogy	Gasterosteus
G_aculeatus_ENSGACP00000016969	paralogy	Gasterosteus
G_aculeatus_ENSGACP00000016983	paralogy	Gasterosteus
CASP3 (4 of 4)	paralogy	Gasterosteus
CASP6	paralogy	Gasterosteus
CASP3 (3 of 4)	paralogy	Gasterosteus
CASP3 (2 of 4)	paralogy	Gasterosteus
CASP3 (1 of 4)	paralogy	Gasterosteus
CASP8	paralogy	Gorilla
CASP7	paralogy	Gorilla
CASP7	paralogy	Horse
CASP9	paralogy	Horse
Q3S2Z5_HORSE	paralogy	Horse
CASP8	paralogy	Horse
CASP6	paralogy	Horse
CASP6	paralogy	Human
CASP10	paralogy	Human
CASP3	paralogy	Human
CASP8	paralogy	Human
CASP7	paralogy	Human
CASP9	paralogy	Human
CASP10	paralogy	Lyzard
CASP3	paralogy	Lyzard
CASP7	paralogy	Lyzard
CASP6	paralogy	Lyzard
CASP7	paralogy	Macaca
Q8SPU2_MACMU	paralogy	Macaca
CASP8	paralogy	Macaca
CASP9	paralogy	Macaca
Q8JIS9_ORYLA	paralogy	Medaka
Q8JIS8_ORYLA	paralogy	Medaka
Q56VC9_ORYLA	paralogy	Medaka
CASP8	paralogy	Monodelphis
CASP9	paralogy	Monodelphis
NP_001033059.1	paralogy	Monodelphis
NP_001033061.1	paralogy	Monodelphis
CASP6	paralogy	Monodelphis
Casp7	paralogy	Mouse
Casp8	paralogy	Mouse
Casp6	paralogy	Mouse
Casp9	paralogy	Mouse
Casp3	paralogy	Mouse
CASP9	paralogy	Orangutan
CASP7	paralogy	Orangutan
Q5RB11_PONPY	paralogy	Orangutan
Q5RCR7_PONPY	paralogy	Orangutan
CASP6	paralogy	Orangutan
CASP3	paralogy	Orangutan
CASP3	paralogy	Ornithorhynchus
O_anatinus_ENSOANP00000001054	paralogy	Ornithorhynchus
CASP7	paralogy	Ornithorhynchus
CASP10	paralogy	Ornithorhynchus
CASP6	paralogy	Ornithorhynchus
CASP8	paralogy	Ornithorhynchus
CASP9	paralogy	Ornithorhynchus
CASP8	paralogy	Rabbit
CASP7	paralogy	Rabbit
Casp6	paralogy	Rat
Casp3	paralogy	Rat
Casp8	paralogy	Rat
Casp9	paralogy	Rat
Casp7	paralogy	Rat
T_nigroviridis_ENSTNIP00000001216	paralogy	Tetraodon
CASP3	paralogy	Tetraodon
T_nigroviridis_ENSTNIP00000010722	paralogy	Tetraodon
CASP9	paralogy	Tetraodon
CASP6	paralogy	Tetraodon
CASP7	paralogy	Tetraodon
CASP3	paralogy	Xenopus
casp10	paralogy	Xenopus
casp7	paralogy	Xenopus
T_guttata_ENSTGUP00000004278	paralogy	Zebra finch
CASP3	paralogy	Zebra finch
CASP8	paralogy	Zebra finch
T_guttata_ENSTGUP00000011206	paralogy	Zebra finch
CASP9	paralogy	Zebra finch
casp3a	paralogy	Zebrafish
casp7	paralogy	Zebrafish
casp8l2	paralogy	Zebrafish
casp6l1	paralogy	Zebrafish
D_rerio_ENSDARP00000047019	paralogy	Zebrafish
casp6	paralogy	Zebrafish
casp3b	paralogy	Zebrafish
LOC100000522	paralogy	Zebrafish
A2BGE2_DANRE	paralogy	Zebrafish
casp8l1	paralogy	Zebrafish
LOC795066	paralogy	Zebrafish
casp6l2	paralogy	Zebrafish
casp8	paralogy	Zebrafish

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0006508	proteolysis	biological_proccess	IEA
GO:0019538	protein metabolic process	biological_proccess	IEA
GO:0004177	aminopeptidase activity	mollecular_function	IEA
GO:0008235	metalloexopeptidase activity	mollecular_function	IEA
GO:0016787	hydrolase activity	mollecular_function	IEA
GO:0030145	manganese ion binding	mollecular_function	IEA
GO:0005622	intracellular	cell_component	IEA
GO:0005737	cytoplasm	cell_component	IEA

Information from other databases [+]

Gene related links:

Gene info from FyBase [?] FBgn0033051
Ensembl genome browser [?] : FBgn0033051
Expression info from Arrayexpress [?] : FBgn0033051
Protein expression from Protein Atlas: [?] FBgn0033051

Other links

entrezgene: 35528
refseq_dna: NM_136349
refseq_peptide: NP_610193

Click on [?] for more information.