TLR4_HORSE (Equus caballus)

Description [+]

Synonyms: TLR4_HORSE
Species: Equus caballus
Short gene description: Toll-like receptor 4 precursor (CD284 antigen). [Source:UniProtKB/Swiss-Prot;Acc:Q9MYW3]
Family: Null
Process:
Pathways:
Criteria: homology search
Curator comment: Null
WIKI: TLR4_HORSE-E_caballus

Structure & Sequence [+]

Pfam domains: (Pfam is a large collection of protein families.)

Source	Domain Name	Start	End
PFAM A	TIR	678	816

Protein sequence [+]

Structure links:

Smartdomain prediction information: SM00365
Smartdomain prediction information: SM00369
Smartdomain prediction information: SM00367
Smartdomain prediction information: SM00082
Smartdomain prediction information: SM00255
Interpro domain information: Q9MYW3
PFAM domain and domain family information: Q9MYW3

Evolution [+]

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0007165	signal transduction	biological_proccess	IEA
GO:0045087	innate immune response	biological_proccess	IEA
GO:0006954	inflammatory response	biological_proccess	IEA
GO:0006955	immune response	biological_proccess	IEA
GO:0042116	macrophage activation	biological_proccess	ISS
GO:0045084	positive regulation of interleukin-12 biosynthetic process	biological_proccess	IEA
GO:0042116	macrophage activation	biological_proccess	IEA
GO:0032497	detection of lipopolysaccharide	biological_proccess	IEA
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	biological_proccess	IEA
GO:0045416	positive regulation of interleukin-8 biosynthetic process	biological_proccess	IEA
GO:0032760	positive regulation of tumor necrosis factor production	biological_proccess	IEA
GO:0032496	response to lipopolysaccharide	biological_proccess	IEA
GO:0032755	positive regulation of interleukin-6 production	biological_proccess	IEA
GO:0032874	positive regulation of stress-activated MAPK cascade	biological_proccess	IEA
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	biological_proccess	IEA
GO:0046330	positive regulation of JNK cascade	biological_proccess	IEA
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological_proccess	IEA
GO:0032609	interferon-gamma production	biological_proccess	IEA
GO:0009617	response to bacterium	biological_proccess	IEA
GO:0010572	positive regulation of platelet activation	biological_proccess	IEA
GO:0002537	production of nitric oxide during acute inflammatory response	biological_proccess	IEA
GO:0070430	positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	biological_proccess	IEA
GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	biological_proccess	IEA
GO:0004872	receptor activity	mollecular_function	IEA
GO:0004888	transmembrane receptor activity	mollecular_function	IEA
GO:0005515	protein binding	mollecular_function	IEA
GO:0001875	lipopolysaccharide receptor activity	mollecular_function	IEA
GO:0031224	intrinsic to membrane	cell_component	IEA
GO:0016020	membrane	cell_component	IEA
GO:0016021	integral to membrane	cell_component	IEA
GO:0005887	integral to plasma membrane	cell_component	IEA
GO:0009897	external side of plasma membrane	cell_component	IEA
GO:0048471	perinuclear region of cytoplasm	cell_component	IEA

Check GO Evidence Codes here

Information from other databases [+]

Gene related links:

Ensembl genome browser [?] : ENSECAG00000010339
Expression info from Arrayexpress [?] : ENSECAG00000010339
Protein expression from Protein Atlas: [?] ENSECAG00000010339
Community gene edition from Wikigenes: [?] 100066890

Protein related links:

Uniprot protein info: Q9MYW3
PIR protein info: Q9MYW3
Protein interactions from IntAct: Q9MYW3

Other links

entrezgene: 100066890
refseq_peptide: NP_001093239

Click on [?] for more information.