ICAM3 (Homo sapiens)
Description [+]
- Synonyms: ICAM3
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
- Short gene description: Intercellular adhesion molecule 3 Precursor (ICAM-3)(ICAM-R)(CDw50)(CD50 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P32942]
- Family: Null
- Process: apoptosis,
- Pathways: apoptotic cell clearance,
- Criteria: manually curated
- Curator comment: Null
- WIKI: ICAM3-H_sapiens
References [+]
- Apoptosis: controlled demolition at the cellular level.
- Taylor RC, Cullen SP, Martin SJ
- Apoptosis is characterized by a series of dramatic perturbations to the cellular architecture that contribute not only to cell death, but also prepare cells for removal by phagocytes and prevent unwanted immune responses. Much of what happens during the demolition phase of apoptosis is orchestrated by members of the caspase family of cysteine proteases. These proteases target several hundred proteins for restricted proteolysis in a controlled manner that minimizes damage and disruption to neighbouring cells and avoids the release of immunostimulatory molecules. Nat Rev Mol Cell Biol. 2008 Mar;9(3):231-41.
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
| Source | Domain Name | Start | End |
|---|---|---|---|
| PFAM A | ICAM_N | 12 | 119 |
Protein sequence [+]
ICAM3 | Homo sapiens | 9606 | length:547
MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSS
EKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERV
ELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLAS
RDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVD
CTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGG
ERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQL
QLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHV
LQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIE
AGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMG
EEPSRAE
EKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERV
ELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLAS
RDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVD
CTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGG
ERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQL
QLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHV
LQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIE
AGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMG
EEPSRAE
Evolution [+]
View protein alignment and tree with Jalview:
Explore tree at phylomeDB: Click here.
Homologs list [+]
| Name | Relationship | Species |
|---|---|---|
| ICAM3_PANTR | orthology | Chimpanzee |
| ICAM3_BOVIN | orthology | Cow |
| ICAM3 | orthology | Gorilla |
| ICAM3 | orthology | Horse |
| A_carolinensis_ENSACAP00000002045 | orthology | Lyzard |
| Q5NKT9_MACMU | orthology | Macaca |
| Q5NKU0_PONPY | orthology | Orangutan |
| O_anatinus_ENSOANP00000021904 | orthology | Ornithorhynchus |
| O_anatinus_ENSOANP00000024823 | orthology | Ornithorhynchus |
| X_tropicalis_ENSXETP00000056666 | orthology | Xenopus |
| ICAM2_PANTR | paralogy | Chimpanzee |
| ICAM1_PANTR | paralogy | Chimpanzee |
| ICAM5 | paralogy | Chimpanzee |
| ICAM4_PANTR | paralogy | Chimpanzee |
| CADM3 | paralogy | Chimpanzee |
| ICAM1_BOVIN | paralogy | Cow |
| IPI00687879.2 | paralogy | Cow |
| IPI00713214.2 | paralogy | Cow |
| NP_001069414.1 | paralogy | Cow |
| NP_001033300.1 | paralogy | Cow |
| IPI00697893.3 | paralogy | Cow |
| CADM3 | paralogy | Dog |
| ICAM2 | paralogy | Dog |
| LOC480476 | paralogy | Dog |
| ICAM5 | paralogy | Dog |
| ICAM4 | paralogy | Dog |
| CADM3 | paralogy | Gorilla |
| ICAM1 | paralogy | Gorilla |
| ICAM5 | paralogy | Gorilla |
| ICAM2 | paralogy | Horse |
| ICAM5 | paralogy | Horse |
| ICAM4 | paralogy | Horse |
| ICAM1 | paralogy | Horse |
| ICAM1 | paralogy | Human |
| CADM3 | paralogy | Human |
| ICAM5 | paralogy | Human |
| ICAM2 | paralogy | Human |
| CADM3 | paralogy | Macaca |
| XM_001109017.1 | paralogy | Macaca |
| ICAM4 | paralogy | Macaca |
| Q5NKU8_MACMU | paralogy | Macaca |
| ICAM1_MACMU | paralogy | Macaca |
| ICAM5 | paralogy | Monodelphis |
| XM_001367322.1 | paralogy | Monodelphis |
| ICAM2 | paralogy | Monodelphis |
| Icam4 | paralogy | Mouse |
| Icam5 | paralogy | Mouse |
| Icam1 | paralogy | Mouse |
| Icam2 | paralogy | Mouse |
| Tcam1 | paralogy | Mouse |
| CADM3 | paralogy | Orangutan |
| ICAM2 | paralogy | Orangutan |
| Q5NKV5_PONPY | paralogy | Orangutan |
| ICAM4 | paralogy | Orangutan |
| ICAM5 | paralogy | Rabbit |
| ICAM2 | paralogy | Rabbit |
| CADM3 | paralogy | Rabbit |
| NP_067705.1 | paralogy | Rat |
| ICAM1_RAT | paralogy | Rat |
| Icam5 | paralogy | Rat |
| NP_001007726.1 | paralogy | Rat |
| VCAM1 | paralogy | Zebra finch |
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Gene Ontology [+]
| GO id | Name | Ontology type | Evidence |
|---|---|---|---|
| GO:0016337 | cell-cell adhesion | biological_proccess | IEA |
| GO:0005178 | integrin binding | mollecular_function | TAS |
| GO:0005886 | plasma membrane | cell_component | NAS |
| GO:0005887 | integral to plasma membrane | cell_component | TAS |
| GO:0016020 | membrane | cell_component | IEA |
Check GO Evidence Codes here
Information from other databases [+]
- Ensembl genome browser [?] : ENSG00000076662
- Expression info from Arrayexpress [?] : ENSG00000076662
- Protein expression from Protein Atlas: [?] ENSG00000076662
Click on [?] for more information.
