PARP2 (Homo sapiens)
Description [+]
- Synonyms: PARP2
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
- Short gene description: Poly [ADP-ribose] polymerase 2 (PARP-2)(EC 2.4.2.30)(NAD(+) ADP-ribosyltransferase 2)(Poly[ADP-ribose] synthetase 2)(pADPRT-2)(hPARP-2) [Source:UniProtKB/Swiss-Prot;Acc:Q9UGN5]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: PARP2-H_sapiens
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | WGR | 110 | 195 |
PFAM A | PARP_reg | 231 | 363 |
PFAM A | PARP | 365 | 577 |
Protein sequence [+]
PARP2 | Homo sapiens | 9606 | length:583
MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
Structure links:
- Smartdomain prediction information: SM00773
- Prosite motif and domain information: PS00867
- Prosite motif and domain information: PS01121
- Profile motif and domain profile information: PS51059
- Profile motif and domain profile information: PS51060
- Interpro domain information: Q9UGN5
- PFAM domain and domain family information: Q9UGN5
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0006471 | protein amino acid ADP-ribosylation | biological_proccess | IEA |
GO:0006508 | proteolysis | biological_proccess | IEA |
GO:0008152 | metabolic process | biological_proccess | IEA |
GO:0006471 | protein amino acid ADP-ribosylation | biological_proccess | TAS |
GO:0006284 | base-excision repair | biological_proccess | IEA |
GO:0003950 | NAD+ ADP-ribosyltransferase activity | mollecular_function | IEA |
GO:0004197 | cysteine-type endopeptidase activity | mollecular_function | IEA |
GO:0003824 | catalytic activity | mollecular_function | IEA |
GO:0005524 | ATP binding | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IPI |
GO:0003677 | DNA binding | mollecular_function | IEA |
GO:0016757 | transferase activity, transferring glycosyl groups | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IEA |
GO:0005634 | nucleus | cell_component | IEA |
GO:0005654 | nucleoplasm | cell_component | IDA |
GO:0005730 | nucleolus | cell_component | IDA |
GO:0005730 | nucleolus | cell_component | IEA |
GO:0005654 | nucleoplasm | cell_component | IEA |
Check GO Evidence Codes here
KEGG Pathways [+]
Information from other databases [+]
- Gene info from HGNC [?] :272
- Gene related info from GeneCards [?] : PARP2
- Ensembl genome browser [?] : ENSG00000129484
- Expression info from Arrayexpress [?] : ENSG00000129484
- Protein expression from Protein Atlas: [?] ENSG00000129484
- Community gene edition from Wikigenes: [?] 10038
- OMIM gene information: 607725
- OMIM disease information:
- entrezgene: 10038
- refseq_dna: NM_001042618
- refseq_dna: NM_005484
- refseq_peptide: NP_005475
- refseq_peptide: NP_001036083
Click on [?] for more information.