TP53 (Homo sapiens)
Description [+]
- Synonyms: TP53, P53, LFS1
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
- Short gene description: Cellular tumor antigen p53 (Tumor suppressor p53)(Phosphoprotein p53)(Antigen NY-CO-13) [Source:UniProtKB/Swiss-Prot;Acc:P04637]
- Family: other
- Process: apoptosis,
- Pathways: intrinsic pathway, pre-mitochondrial signaling events,
- Criteria: manually curated
- Curator comment:
- Mouse ortholog(s): Trp53
- WIKI: TP53-H_sapiens
References [+]
- Blinded by the Light: The Growing Complexity of p53.
- Vousden KH, Prives C
- While the tumor suppressor functions of p53 have long been recognized, the contribution of p53 to numerous other aspects of disease and normal life is only now being appreciated. This burgeoning range of responses to p53 is reflected by an increasing variety of mechanisms through which p53 can function, although the ability to activate transcription remains key to p53's modus operandi. Control of p53's transcriptional activity is crucial for determining which p53 response is activated, a decision we must understand if we are to exploit efficiently the next generation of drugs that selectively activate or inhibit p53. Cell. 2009 May 1;137(3):413-31.
- Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.
- Shaw P, Bovey R, Tardy S, Sahli R, Sordat B, Costa J
- A wild-type p53 gene under control of the metallothionein MT-1 promoter was stably transfected into human colon tumor-derived cell line EB. Repeated inductions of the metallothionein wild-type p53 gene with zinc chloride results in progressive detachment of wild-type p53 cells grown on culture dishes. Examination at both the light and electron microscopic level revealed that cells expressing wild-type p53 developed morphological features of apoptosis. DNA from both attached and detached cells was degraded into a ladder of nucleosomal-sized fragments. Expression of wild-type p53 inhibited colony formation in soft agar and tumor formation in nude mice. Furthermore, established tumors in nude mice underwent regression if wild-type p53 expression was subsequently induced. Regressing tumors showed histological features of apoptosis. Thus, regression of these tumors was the result of apoptosis occurring in vivo. Apoptosis may be a normal part of the terminal differentiation program of colonic epithelial cells. Our results suggest that wild-type p53 could play a critical role in this process. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4495-9.
- References from Mouse ortholog(s):
- Blinded by the Light: The Growing Complexity of p53.
- Vousden KH, Prives C
- While the tumor suppressor functions of p53 have long been recognized, the contribution of p53 to numerous other aspects of disease and normal life is only now being appreciated. This burgeoning range of responses to p53 is reflected by an increasing variety of mechanisms through which p53 can function, although the ability to activate transcription remains key to p53's modus operandi. Control of p53's transcriptional activity is crucial for determining which p53 response is activated, a decision we must understand if we are to exploit efficiently the next generation of drugs that selectively activate or inhibit p53. Cell. 2009 May 1;137(3):413-31.
- Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents.
- Lotem J, Sachs L
- Wild-type p53 is a tumor-suppressor gene that can induce cell death by apoptosis when expressed in myeloid leukemic and some other types of tumor cells. However, the question remained as to what extent wild-type p53 is a mediator of apoptosis in normal cells. We have used mice deficient in wild-type p53 to determine whether induction of apoptosis in hematopoietic cells from these p53 deficient mice is defective. We show here that bone marrow myeloid progenitor cells from p53-deficient mice are more resistant to induction of apoptosis when there was only a low concentration of the viability factors granulocyte-macrophage colony-stimulating factor; interleukins-1 alpha, -3, and -6; or stem cell factor; or when apoptosis was induced in these cells by irradiation or heat shock. The loss of one allele of wild-type p53 was sufficient for increased resistance. The higher resistance to apoptosis in p53-deficient mice was also found in irradiated thymocytes, but not in thymocytes treated with dexamethasone or in mature peritoneal granulocytes. The degree of resistance in irradiated myeloid progenitors and thymocytes showed a dosage effect of the number of wild-type p53 genes. The results show that wild-type p53 is involved in the induction of apoptosis by some agents in normal hematopoietic cells. Loss of wild-type p53 can, therefore, contribute to tumor development by decreasing cell death at low concentrations of viability factors and after exposure to a DNA-damaging agent. The results also show that there are wild-type p53-dependent and -independent pathways of normal cell apoptosis. Blood. 1993 Aug 15;82(4):1092-6.
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | P53_TAD | 5 | 29 |
PFAM A | P53 | 95 | 289 |
PFAM A | P53_tetramer | 318 | 359 |
Protein sequence [+]
TP53 | Homo sapiens | 9606 | length:393
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Structure links:
Evolution [+]
View protein alignment and tree with Jalview:  
Explore tree at phylomeDB:   Click here.
Homologs list [+]
Name | Relationship | Species |
---|---|---|
A_aegypti_AAEL007594-PA | orthology | Aedes |
A_aegypti_AAEL007595-PA | orthology | Aedes |
A_gambiae_AGAP002352-PA | orthology | Anopheles |
A_gambiae_AGAP004319-PA | orthology | Anopheles |
TP53 | orthology | Chimpanzee |
Q4H301_CIOIN | orthology | Ciona |
Q4H2Z8_CIOIN | orthology | Ciona |
P53_BOVIN | orthology | Cow |
P53_CANFA | orthology | Dog |
p53 | orthology | Fly |
TP53 | orthology | Fugu |
TP53 | orthology | Gasterosteus |
Q9N1F3_9PRIM | orthology | Gorilla |
Q29484_HORSE | orthology | Horse |
P53_MACMU | orthology | Macaca |
P53_ORYLA | orthology | Medaka |
Trp53 | orthology | Mouse |
TP53 | orthology | Orangutan |
P53_RABIT | orthology | Rabbit |
Tp53 | orthology | Rat |
TP53 | orthology | Tetraodon |
tp53 | orthology | Xenopus |
D_rerio_ENSDARP00000051548 | orthology | Zebrafish |
TP73 | paralogy | Chicken |
NP_989682.1 | paralogy | Chicken |
TP73 | paralogy | Chimpanzee |
TP63 | paralogy | Chimpanzee |
IPI00690378.2 | paralogy | Cow |
IPI00700517.4 | paralogy | Cow |
TP63 | paralogy | Dog |
Q8WMQ8_CANFA | paralogy | Dog |
TP63 | paralogy | Fugu |
TP73 | paralogy | Fugu |
TP73 | paralogy | Gasterosteus |
TP63 | paralogy | Gasterosteus |
TP63 | paralogy | Gorilla |
TP73 | paralogy | Gorilla |
TP63 | paralogy | Horse |
TP73 | paralogy | Horse |
TP63 | paralogy | Human |
TP73 | paralogy | Human |
TP63 | paralogy | Lyzard |
TP73 | paralogy | Lyzard |
TP63 | paralogy | Macaca |
TP73 | paralogy | Macaca |
TP73 | paralogy | Medaka |
TP63 | paralogy | Medaka |
TP73 | paralogy | Monodelphis |
TP63 | paralogy | Monodelphis |
Trp73 | paralogy | Mouse |
Trp63 | paralogy | Mouse |
TP73 | paralogy | Orangutan |
TP63 | paralogy | Orangutan |
TP73 | paralogy | Ornithorhynchus |
TP63 | paralogy | Ornithorhynchus |
TP63 | paralogy | Rabbit |
Trp63 | paralogy | Rat |
NP_001102166.1 | paralogy | Rat |
TP73 | paralogy | Tetraodon |
TP63 | paralogy | Tetraodon |
TP73 | paralogy | Xenopus |
TP73 | paralogy | Zebra finch |
TP63 | paralogy | Zebra finch |
tp73l | paralogy | Zebrafish |
tp73 | paralogy | Zebrafish |
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-dependent | biological_proccess | IEA |
GO:0045449 | regulation of transcription | biological_proccess | IEA |
GO:0002347 | response to tumor cell | biological_proccess | IEA |
GO:0030308 | negative regulation of cell growth | biological_proccess | IEA |
GO:0010552 | positive regulation of specific transcription from RNA polymerase II promoter | biological_proccess | IDA |
GO:0000060 | protein import into nucleus, translocation | biological_proccess | IEA |
GO:0001701 | in utero embryonic development | biological_proccess | IEA |
GO:0001836 | release of cytochrome c from mitochondria | biological_proccess | IEA |
GO:0002309 | T cell proliferation during immune response | biological_proccess | IEA |
GO:0002360 | T cell lineage commitment | biological_proccess | IEA |
GO:0007369 | gastrulation | biological_proccess | IEA |
GO:0007417 | central nervous system development | biological_proccess | IEA |
GO:0008156 | negative regulation of DNA replication | biological_proccess | IEA |
GO:0009792 | embryonic development ending in birth or egg hatching | biological_proccess | IEA |
GO:0010332 | response to gamma radiation | biological_proccess | IEA |
GO:0031571 | G1 DNA damage checkpoint | biological_proccess | IEA |
GO:0034644 | cellular response to UV | biological_proccess | IEA |
GO:0042493 | response to drug | biological_proccess | IEA |
GO:0043525 | positive regulation of neuron apoptosis | biological_proccess | IEA |
GO:0048147 | negative regulation of fibroblast proliferation | biological_proccess | IEA |
GO:0051453 | regulation of intracellular pH | biological_proccess | IEA |
GO:0008629 | induction of apoptosis by intracellular signals | biological_proccess | TAS |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological_proccess | IEA |
GO:0002326 | B cell lineage commitment | biological_proccess | IEA |
GO:0007406 | negative regulation of neuroblast proliferation | biological_proccess | IEA |
GO:0009651 | response to salt stress | biological_proccess | IEA |
GO:0033077 | T cell differentiation in the thymus | biological_proccess | IEA |
GO:0043066 | negative regulation of apoptosis | biological_proccess | IEA |
GO:0051276 | chromosome organization | biological_proccess | IEA |
GO:0006983 | ER overload response | biological_proccess | IDA |
GO:0042149 | cellular response to glucose starvation | biological_proccess | IDA |
GO:0042771 | DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis | biological_proccess | IDA |
GO:0010165 | response to X-ray | biological_proccess | IEA |
GO:0007049 | cell cycle | biological_proccess | IEA |
GO:0044419 | interspecies interaction between organisms | biological_proccess | IEA |
GO:0007569 | cell aging | biological_proccess | IMP |
GO:0051262 | protein tetramerization | biological_proccess | TAS |
GO:0006974 | response to DNA damage stimulus | biological_proccess | IEP |
GO:0007050 | cell cycle arrest | biological_proccess | TAS |
GO:0030154 | cell differentiation | biological_proccess | TAS |
GO:0008283 | cell proliferation | biological_proccess | TAS |
GO:0006355 | regulation of transcription, DNA-dependent | biological_proccess | IDA |
GO:0006289 | nucleotide-excision repair | biological_proccess | IMP |
GO:0006284 | base-excision repair | biological_proccess | TAS |
GO:0006461 | protein complex assembly | biological_proccess | IDA |
GO:0008104 | protein localization | biological_proccess | IDA |
GO:0007275 | multicellular organismal development | biological_proccess | IMP |
GO:0046902 | regulation of mitochondrial membrane permeability | biological_proccess | TAS |
GO:0008635 | activation of caspase activity by cytochrome c | biological_proccess | IDA |
GO:0051097 | negative regulation of helicase activity | biological_proccess | TAS |
GO:0006302 | double-strand break repair | biological_proccess | IEA |
GO:0030308 | negative regulation of cell growth | biological_proccess | IMP |
GO:0006915 | apoptosis | biological_proccess | IEA |
GO:0045893 | positive regulation of transcription, DNA-dependent | biological_proccess | IEA |
GO:0045941 | positive regulation of transcription | biological_proccess | IEA |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological_proccess | IEA |
GO:0009303 | rRNA transcription | biological_proccess | IEA |
GO:0006974 | response to DNA damage stimulus | biological_proccess | IEA |
GO:0008285 | negative regulation of cell proliferation | biological_proccess | IEA |
GO:0042127 | regulation of cell proliferation | biological_proccess | IEA |
GO:0006917 | induction of apoptosis | biological_proccess | IEA |
GO:0051726 | regulation of cell cycle | biological_proccess | IEA |
GO:0007569 | cell aging | biological_proccess | IEA |
GO:0042771 | DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis | biological_proccess | IEA |
GO:0043065 | positive regulation of apoptosis | biological_proccess | IEA |
GO:0030330 | DNA damage response, signal transduction by p53 class mediator | biological_proccess | IEA |
GO:0009411 | response to UV | biological_proccess | IEA |
GO:0043523 | regulation of neuron apoptosis | biological_proccess | IEA |
GO:0046902 | regulation of mitochondrial membrane permeability | biological_proccess | IEA |
GO:0003677 | DNA binding | mollecular_function | IEA |
GO:0003700 | transcription factor activity | mollecular_function | IEA |
GO:0008270 | zinc ion binding | mollecular_function | IEA |
GO:0008134 | transcription factor binding | mollecular_function | IPI |
GO:0010843 | promoter binding | mollecular_function | IDA |
GO:0003682 | chromatin binding | mollecular_function | IDA |
GO:0046872 | metal ion binding | mollecular_function | IEA |
GO:0003700 | transcription factor activity | mollecular_function | IDA |
GO:0000739 | DNA strand annealing activity | mollecular_function | IDA |
GO:0005524 | ATP binding | mollecular_function | IDA |
GO:0008270 | zinc ion binding | mollecular_function | TAS |
GO:0046982 | protein heterodimerization activity | mollecular_function | IPI |
GO:0019899 | enzyme binding | mollecular_function | IPI |
GO:0051087 | chaperone binding | mollecular_function | IPI |
GO:0047485 | protein N-terminus binding | mollecular_function | IPI |
GO:0005507 | copper ion binding | mollecular_function | IDA |
GO:0005515 | protein binding | mollecular_function | IEA |
GO:0005634 | nucleus | cell_component | IEA |
GO:0016605 | PML body | cell_component | IDA |
GO:0005669 | transcription factor TFIID complex | cell_component | IDA |
GO:0005657 | replication fork | cell_component | IEA |
GO:0005829 | cytosol | cell_component | IEA |
GO:0005783 | endoplasmic reticulum | cell_component | IEA |
GO:0005730 | nucleolus | cell_component | IDA |
GO:0005634 | nucleus | cell_component | IDA |
GO:0005654 | nucleoplasm | cell_component | IDA |
GO:0005626 | insoluble fraction | cell_component | IDA |
GO:0016363 | nuclear matrix | cell_component | IDA |
GO:0005737 | cytoplasm | cell_component | IDA |
GO:0005739 | mitochondrion | cell_component | IDA |
GO:0005737 | cytoplasm | cell_component | IEA |
Check GO Evidence Codes here
Information from other databases [+]
- Gene info from HGNC [?] :11998
- Gene related info from GeneCards [?] : TP53
- Ensembl genome browser [?] : ENSG00000141510
- Expression info from Arrayexpress [?] : ENSG00000141510
- Protein expression from Protein Atlas: [?] ENSG00000141510
- Community gene edition from Wikigenes: [?] 7157
- entrezgene: 7157
- refseq_dna: NM_001126116
- refseq_dna: NM_001126114
- refseq_dna: NM_000546
- refseq_dna: NM_001126117
- refseq_dna: NM_001126115
- refseq_dna: NM_001126113
- refseq_dna: NM_001126112
- refseq_peptide: NP_001119588
- refseq_peptide: NP_001119586
- refseq_peptide: NP_001119589
- refseq_peptide: NP_001119587
- refseq_peptide: NP_001119585
- refseq_peptide: NP_001119584
- refseq_peptide: NP_000537
Click on [?] for more information.