HTRA3 (Homo sapiens)
Description [+]
- Synonyms: HTRA3
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
- Short gene description: Probable serine protease HTRA3 Precursor (EC 3.4.21.-)(High-temperature requirement factor A3)(Pregnancy-related serine protease) [Source:UniProtKB/Swiss-Prot;Acc:P83110]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: HTRA3-H_sapiens
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | Kazal_2 | 75 | 126 |
PFAM A | Kazal_1 | 76 | 126 |
PFAM A | Trypsin | 164 | 341 |
PFAM A | PDZ | 348 | 437 |
Protein sequence [+]
HTRA3 | Homo sapiens | 9606 | length:453
MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE
PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ
LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM
SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP
VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII
NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIR
MRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS
ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM
PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ
LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM
SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP
VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII
NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIR
MRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS
ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM
Structure links:
- Smartdomain prediction information: SM00121
- Smartdomain prediction information: SM00280
- Smartdomain prediction information: SM00228
- Profile motif and domain profile information: PS50311
- Profile motif and domain profile information: PS50106
- Interpro domain information: P83110
- PFAM domain and domain family information: P83110
- Protein 3D structures from PDB: 2P3W
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0001558 | regulation of cell growth | biological_proccess | IEA |
GO:0006508 | proteolysis | biological_proccess | IEA |
GO:0004252 | serine-type endopeptidase activity | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IEA |
GO:0005520 | insulin-like growth factor binding | mollecular_function | IEA |
GO:0008233 | peptidase activity | mollecular_function | IEA |
GO:0008236 | serine-type peptidase activity | mollecular_function | IEA |
GO:0003824 | catalytic activity | mollecular_function | IEA |
GO:0005576 | extracellular region | cell_component | IEA |
Check GO Evidence Codes here
Information from other databases [+]
- Gene info from HGNC [?] :30406
- Gene related info from GeneCards [?] : HTRA3
- Ensembl genome browser [?] : ENSG00000170801
- Expression info from Arrayexpress [?] : ENSG00000170801
- Protein expression from Protein Atlas: [?] ENSG00000170801
- Community gene edition from Wikigenes: [?] 94031
- OMIM gene information: 608785
- OMIM disease information:
Click on [?] for more information.