Your are not logged in. Log in.

CYTOCHROME C   (Homo sapiens)

Description [+]
  • Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
  • Short gene description: Cytochrome c [Source:UniProtKB/Swiss-Prot;Acc:P99999]
  • Family: Other
  • Process: apoptosis,
  • Pathways: intrinsic pathway, post-mitochondrial caspase activation,
  • Criteria: manually curated
  • Curator comment: Cytochrome c is a nuclear encoded gene that upon import into the mitochondria obtains a heme moiety forming the holoenzyme. In healthy cells, cytochrome c resides in the mitochondrial intermembrane space where it is required for oxidative phosphorylation by transferring electrons between complexes III and IV of the respiratory chain. During apoptosis, cytochrome c is released from mitochondria following mitochondrial outer membrane permeabilisation where it drives caspase activation [8689682] . Once in the cytosol, cytochrome c binds Apaf-1 leading to formation of the heptameric Apaf-1 caspase activating platform termed the apoptosome. Cytochrome c is absolutely required for caspase activation in the majority of intrinsic apoptosis pathways 1590747
  • WIKI: CYTOCHROME C-H_sapiens
References [+]
Structure & Sequence [+]
Evolution [+]
Gene Ontology [+]
KEGG Pathways [+]
Curated Isoforms [+]
Information from other databases [+]