TRADD (Homo sapiens)
Description [+]
- Synonyms: TRADD, HS.89862
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
- Short gene description: Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein)(TNFRSF1A-associated via death domain) [Source:UniProtKB/Swiss-Prot;Acc:Q15628]
- Family: Death Domain-containing protein : DD adapter protein
- Process: apoptosis,
- Pathways: extrinsic pathway,
- Criteria: manually curated
- Curator comment:
- Mouse ortholog(s): Tradd
- WIKI: TRADD-H_sapiens
References [+]
- The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation.
- Hsu H, Xiong J, Goeddel DV
- Many diverse activities of tumor necrosis factor (TNF) are signaled through TNF receptor 1 (TNFR1). We have identified a novel 34 kDa protein, designated TRADD, that specifically interacts with an intracellular domain of TNFR1 known to be essential for mediating programmed cell death. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa B. The C-terminal 118 amino acids of TRADD are sufficient to trigger both of these activities and likewise sufficient for interaction with the death domain of TNFR1. TRADD-mediated cell death can be suppressed by the crmA gene, which encodes a specific inhibitor of the interleukin-1 beta-converting enzyme. However, NF-kappa B activation by TRADD is not inhibited by crmA expression, demonstrating that the signaling pathways for TNF-induced cell death and NF-kappa B activation are distinct. Cell. 1995 May 19;81(4):495-504.
- References from Mouse ortholog(s):
- The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation.
- Hsu H, Xiong J, Goeddel DV
- Many diverse activities of tumor necrosis factor (TNF) are signaled through TNF receptor 1 (TNFR1). We have identified a novel 34 kDa protein, designated TRADD, that specifically interacts with an intracellular domain of TNFR1 known to be essential for mediating programmed cell death. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa B. The C-terminal 118 amino acids of TRADD are sufficient to trigger both of these activities and likewise sufficient for interaction with the death domain of TNFR1. TRADD-mediated cell death can be suppressed by the crmA gene, which encodes a specific inhibitor of the interleukin-1 beta-converting enzyme. However, NF-kappa B activation by TRADD is not inhibited by crmA expression, demonstrating that the signaling pathways for TNF-induced cell death and NF-kappa B activation are distinct. Cell. 1995 May 19;81(4):495-504.
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | TRADD_N | 51 | 161 |
Protein sequence [+]
TRADD | Homo sapiens | 9606 | length:312
MAAGQNGHEEWVGSAYLFVESSLDKVVLSDAYAHPQQKVAVYRALQAALAESGGSPDVLQ
MLKIHRSDPQLIVQLRFCGRQPCGRFLRAYREGALRAALQRSLAAALAQHSVPLQLELRA
GAERLDALLADEERCLSCILAQQPDRLRDEELAELEDALRNLKCGSGARGGDGEVASAPL
QPPVPSLSEVKPPPPPPPAQTFLFQGQPVVNRPLSLKDQQTFARSVGLKWRKVGRSLQRG
CRALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRRATLQRLVEALEENELTSLAED
LLGLTDPNGGLA
MLKIHRSDPQLIVQLRFCGRQPCGRFLRAYREGALRAALQRSLAAALAQHSVPLQLELRA
GAERLDALLADEERCLSCILAQQPDRLRDEELAELEDALRNLKCGSGARGGDGEVASAPL
QPPVPSLSEVKPPPPPPPAQTFLFQGQPVVNRPLSLKDQQTFARSVGLKWRKVGRSLQRG
CRALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRRATLQRLVEALEENELTSLAED
LLGLTDPNGGLA
Structure links:
Evolution [+]
View protein alignment and tree with Jalview:  
Explore tree at phylomeDB:   Click here.
Homologs list [+]
Name | Relationship | Species |
---|---|---|
TRADD | orthology | Chicken |
TRADD | orthology | Chimpanzee |
TRADD_BOVIN | orthology | Cow |
TRADD | orthology | Dog |
TRADD | orthology | Fugu |
TRADD | orthology | Gasterosteus |
TRADD | orthology | Gorilla |
TRADD | orthology | Horse |
TRADD | orthology | Macaca |
TRADD | orthology | Medaka |
TRADD | orthology | Monodelphis |
Tradd | orthology | Mouse |
TRADD | orthology | Orangutan |
Tradd | orthology | Rat |
TRADD | orthology | Tetraodon |
TRADD | orthology | Zebra finch |
tradd | orthology | Zebrafish |
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0033209 | tumor necrosis factor-mediated signaling pathway | biological_proccess | TAS |
GO:0051798 | positive regulation of hair follicle development | biological_proccess | IEA |
GO:0006917 | induction of apoptosis | biological_proccess | TAS |
GO:0007165 | signal transduction | biological_proccess | TAS |
GO:0008633 | activation of pro-apoptotic gene products | biological_proccess | EXP |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | biological_proccess | IEP |
GO:0006917 | induction of apoptosis | biological_proccess | IEA |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | biological_proccess | IEA |
GO:0019900 | kinase binding | mollecular_function | IPI |
GO:0060090 | molecular adaptor activity | mollecular_function | IPI |
GO:0042802 | identical protein binding | mollecular_function | IPI |
GO:0070513 | death domain binding | mollecular_function | IPI |
GO:0019215 | intermediate filament binding | mollecular_function | IPI |
GO:0004871 | signal transducer activity | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IEA |
GO:0043235 | receptor complex | cell_component | IDA |
GO:0005829 | cytosol | cell_component | EXP |
GO:0005856 | cytoskeleton | cell_component | IEA |
GO:0005737 | cytoplasm | cell_component | IDA |
GO:0005737 | cytoplasm | cell_component | IEA |
Check GO Evidence Codes here
KEGG Pathways [+]
Curated Isoforms [+]
Transcript | Translation |
---|---|
OTTHUMT00000268841 * | OTTHUMP00000174816 * |
OTTHUMT00000268842 |
Info from The Vertebrate Genome Annotation (VEGA) database.
(*) Canonical transcript and translation forms.
Information from other databases [+]
- Gene info from HGNC [?] :12030
- Gene related info from GeneCards [?] : TRADD
- Ensembl genome browser [?] : ENSG00000102871
- Expression info from Arrayexpress [?] : ENSG00000102871
- Protein expression from Protein Atlas: [?] ENSG00000102871
- Community gene edition from Wikigenes: [?] 8717
- OMIM gene information: 603500
- OMIM disease information:
Click on [?] for more information.