MAPK8 (Homo sapiens)
Description [+]
- Synonyms: MAPK8, JNK, JNK1, SAPK1
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
- Short gene description: Mitogen-activated protein kinase 8 (EC 2.7.11.24)(Stress-activated protein kinase JNK1)(c-Jun N-terminal kinase 1)(JNK-46) [Source:UniProtKB/Swiss-Prot;Acc:P45983]
- Family: other
- Process: cell death (other),
- Pathways: TNF/NF-kappaB signaling,
- Criteria: manually curated
- Curator comment:
- Mouse ortholog(s): Mapk8
- WIKI: MAPK8-H_sapiens
References [+]
- JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.
- Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ
- The ultraviolet (UV) response of mammalian cells is characterized by a rapid and selective increase in gene expression mediated by AP-1 and NF-kappa B. The effect on AP-1 transcriptional activity results, in part, from enhanced phosphorylation of the c-Jun NH2-terminal activation domain. Here, we describe the molecular cloning and characterization of JNK1, a distant relative of the MAP kinase group that is activated by dual phosphorylation at Thr and Tyr during the UV response. Significantly, Ha-Ras partially activates JNK1 and potentiates the activation caused by UV. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73. Thus, JNK1 is a component of a novel signal transduction pathway that is activated by oncoproteins and UV irradiation. These properties indicate that JNK1 activation may play an important role in tumor promotion. Cell. 1994 Mar 25;76(6):1025-37.
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
| Source | Domain Name | Start | End |
|---|---|---|---|
| PFAM A | Pkinase | 26 | 321 |
| PFAM A | Pkinase_Tyr | 26 | 256 |
Protein sequence [+]
MAPK8 | Homo sapiens | 9606 | length:427
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
Structure links:
- Smartdomain prediction information: SM00219
- Smartdomain prediction information: SM00220
- Prosite motif and domain information: PS00108
- Prosite motif and domain information: PS01351
- Profile motif and domain profile information: PS50011
- Interpro domain information: P45983
- PFAM domain and domain family information: P45983
- Protein 3D structures from PDB: 2NO3 1UKI 1UKH 2G01 2GMX 2H96
Evolution [+]
View protein alignment and tree with Jalview:
Explore tree at phylomeDB: Click here.
Homologs list [+]
| Name | Relationship | Species |
|---|---|---|
| A_aegypti_AAEL008634-PA | orthology | Aedes |
| A_gambiae_AGAP009461-PA | orthology | Anopheles |
| MAPK8 | orthology | Chicken |
| MAPK8 | orthology | Chimpanzee |
| Q4H3A2_CIOIN | orthology | Ciona |
| NP_001077197.1 | orthology | Cow |
| MAPK8 | orthology | Dog |
| bsk | orthology | Fly |
| MAPK8 | orthology | Gorilla |
| MAPK8 | orthology | Horse |
| MAPK8 | orthology | Lyzard |
| MAPK8 | orthology | Macaca |
| MAPK8 | orthology | Monodelphis |
| Mapk8 | orthology | Mouse |
| MAPK8 | orthology | Orangutan |
| MAPK8 | orthology | Ornithorhynchus |
| MAPK8 | orthology | Rabbit |
| Mapk8 | orthology | Rat |
| jnk-1 | orthology | Worm |
| MAPK8 | orthology | Xenopus |
| MAPK8 | orthology | Zebra finch |
| Q1L0R1_AEDAE | paralogy | Aedes |
| A_aegypti_AAEL008622-PA | paralogy | Aedes |
| A_gambiae_AGAP009460-PA | paralogy | Anopheles |
| NP_001006227.1 | paralogy | Chicken |
| Q5ZLJ0_CHICK | paralogy | Chicken |
| MAPK10 | paralogy | Chicken |
| MAPK13 | paralogy | Chicken |
| MK09_CHICK | paralogy | Chicken |
| MK14_PANTR | paralogy | Chimpanzee |
| MK13_PANTR | paralogy | Chimpanzee |
| MAPK9 | paralogy | Chimpanzee |
| MAPK10 | paralogy | Chimpanzee |
| NP_001095644.1 | paralogy | Cow |
| NM_001083728.1 | paralogy | Cow |
| NP_001039834.1 | paralogy | Cow |
| NP_001073804.1 | paralogy | Cow |
| MK13_BOVIN | paralogy | Cow |
| NP_001092423.1 | paralogy | Cow |
| MAPK10 | paralogy | Dog |
| MK14_CANFA | paralogy | Dog |
| MAPK12 | paralogy | Dog |
| MAPK13 | paralogy | Dog |
| MAPK9 | paralogy | Dog |
| p38b | paralogy | Fly |
| Mpk2 | paralogy | Fly |
| MAPK9 | paralogy | Fugu |
| MAPK11 | paralogy | Fugu |
| MAPK8 (2 of 2) | paralogy | Fugu |
| MAPK10 | paralogy | Fugu |
| MAPK8 (1 of 2) | paralogy | Fugu |
| T_rubripes_ENSTRUP00000021906 | paralogy | Fugu |
| MAPK13 | paralogy | Fugu |
| T_rubripes_ENSTRUP00000041575 | paralogy | Fugu |
| G_aculeatus_ENSGACP00000010808 | paralogy | Gasterosteus |
| MAPK9 | paralogy | Gasterosteus |
| MAPK13 | paralogy | Gasterosteus |
| MAPK12 (1 of 2) | paralogy | Gasterosteus |
| MAPK11 | paralogy | Gasterosteus |
| MAPK8 (1 of 2) | paralogy | Gasterosteus |
| MAPK10 | paralogy | Gasterosteus |
| G_aculeatus_ENSGACP00000010206 | paralogy | Gasterosteus |
| MAPK8 (2 of 2) | paralogy | Gasterosteus |
| MAPK10 | paralogy | Gorilla |
| MAPK9 | paralogy | Gorilla |
| MAPK10 | paralogy | Horse |
| MAPK9 | paralogy | Horse |
| MAPK11 | paralogy | Horse |
| MAPK10 | paralogy | Human |
| MAPK12 | paralogy | Human |
| MAPK9 | paralogy | Human |
| MAPK14 | paralogy | Human |
| MAPK11 | paralogy | Human |
| MAPK13 | paralogy | Human |
| MAPK11 | paralogy | Lyzard |
| MAPK10 | paralogy | Lyzard |
| MAPK9 | paralogy | Lyzard |
| MAPK13 | paralogy | Lyzard |
| MAPK14 | paralogy | Lyzard |
| MAPK10 | paralogy | Macaca |
| MAPK14 | paralogy | Macaca |
| MAPK11 | paralogy | Macaca |
| MAPK12 | paralogy | Macaca |
| MAPK9 | paralogy | Macaca |
| O_latipes_ENSORLP00000008135 | paralogy | Medaka |
| MAPK8 (2 of 2) | paralogy | Medaka |
| MAPK12 (2 of 2) | paralogy | Medaka |
| MAPK13 | paralogy | Medaka |
| MAPK12 (1 of 2) | paralogy | Medaka |
| MAPK10 | paralogy | Medaka |
| MAPK8 (1 of 2) | paralogy | Medaka |
| MAPK9 | paralogy | Medaka |
| MAPK12 | paralogy | Monodelphis |
| MAPK13 | paralogy | Monodelphis |
| MAPK14 | paralogy | Monodelphis |
| MAPK9 | paralogy | Monodelphis |
| MAPK11 | paralogy | Monodelphis |
| MAPK10 | paralogy | Monodelphis |
| Mapk11 | paralogy | Mouse |
| Mapk9 | paralogy | Mouse |
| Mapk12 | paralogy | Mouse |
| Mapk13 | paralogy | Mouse |
| Mapk14 | paralogy | Mouse |
| Mapk10 | paralogy | Mouse |
| MAPK13 | paralogy | Orangutan |
| MAPK14 | paralogy | Orangutan |
| Q5RA26_PONPY | paralogy | Orangutan |
| MAPK9 | paralogy | Orangutan |
| MAPK13 | paralogy | Ornithorhynchus |
| MAPK10 | paralogy | Ornithorhynchus |
| MAPK9 | paralogy | Ornithorhynchus |
| MAPK10 | paralogy | Rabbit |
| MAPK9 | paralogy | Rabbit |
| Mapk12 | paralogy | Rat |
| Mapk14 | paralogy | Rat |
| Mapk10 | paralogy | Rat |
| LOC679007 | paralogy | Rat |
| Mapk13 | paralogy | Rat |
| Mapk9 | paralogy | Rat |
| MAPK8 (1 of 2) | paralogy | Tetraodon |
| MAPK9 | paralogy | Tetraodon |
| MAPK12 (3 of 3) | paralogy | Tetraodon |
| MAPK13 (1 of 2) | paralogy | Tetraodon |
| MAPK11 | paralogy | Tetraodon |
| MAPK10 | paralogy | Tetraodon |
| MAPK12 (2 of 3) | paralogy | Tetraodon |
| MAPK12 (1 of 3) | paralogy | Tetraodon |
| MAPK8 (2 of 2) | paralogy | Tetraodon |
| T_nigroviridis_ENSTNIP00000018173 | paralogy | Tetraodon |
| kgb-1 | paralogy | Worm |
| pmk-1 | paralogy | Worm |
| kgb-2 | paralogy | Worm |
| X_tropicalis_ENSXETP00000000876 | paralogy | Xenopus |
| MAPK10 | paralogy | Xenopus |
| MAPK11 | paralogy | Xenopus |
| mapk12 | paralogy | Xenopus |
| MAPK14 | paralogy | Zebra finch |
| MAPK10 | paralogy | Zebra finch |
| T_guttata_ENSTGUP00000001679 | paralogy | Zebra finch |
| MAPK9 | paralogy | Zebra finch |
| MAPK11 | paralogy | Zebra finch |
| mapk14b | paralogy | Zebrafish |
| LOC100002318 | paralogy | Zebrafish |
| MAPK8 (2 of 2) | paralogy | Zebrafish |
| mapk12 | paralogy | Zebrafish |
| LOC797284 | paralogy | Zebrafish |
| zgc:86905 | paralogy | Zebrafish |
| zgc:123234 | paralogy | Zebrafish |
| mapk8 | paralogy | Zebrafish |
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Gene Ontology [+]
| GO id | Name | Ontology type | Evidence |
|---|---|---|---|
| GO:0006468 | protein amino acid phosphorylation | biological_proccess | IEA |
| GO:0007258 | JUN phosphorylation | biological_proccess | IDA |
| GO:0009411 | response to UV | biological_proccess | IDA |
| GO:0043066 | negative regulation of apoptosis | biological_proccess | IDA |
| GO:0006928 | cell motion | biological_proccess | TAS |
| GO:0006950 | response to stress | biological_proccess | TAS |
| GO:0007165 | signal transduction | biological_proccess | TAS |
| GO:0008633 | activation of pro-apoptotic gene products | biological_proccess | EXP |
| GO:0001503 | ossification | biological_proccess | IEA |
| GO:0007258 | JUN phosphorylation | biological_proccess | IEA |
| GO:0018107 | peptidyl-threonine phosphorylation | biological_proccess | IEA |
| GO:0031558 | induction of apoptosis in response to chemical stimulus | biological_proccess | IEA |
| GO:0046686 | response to cadmium ion | biological_proccess | IEA |
| GO:0004672 | protein kinase activity | mollecular_function | IEA |
| GO:0005524 | ATP binding | mollecular_function | IEA |
| GO:0004707 | MAP kinase activity | mollecular_function | IEA |
| GO:0004674 | protein serine/threonine kinase activity | mollecular_function | IEA |
| GO:0004674 | protein serine/threonine kinase activity | mollecular_function | IDA |
| GO:0000166 | nucleotide binding | mollecular_function | IEA |
| GO:0016740 | transferase activity | mollecular_function | IEA |
| GO:0005515 | protein binding | mollecular_function | IPI |
| GO:0004705 | JUN kinase activity | mollecular_function | IDA |
| GO:0004713 | protein tyrosine kinase activity | mollecular_function | IEA |
| GO:0005829 | cytosol | cell_component | EXP |
| GO:0005634 | nucleus | cell_component | IEA |
| GO:0005737 | cytoplasm | cell_component | IEA |
Check GO Evidence Codes here
Curated Isoforms [+]
Info from The Vertebrate Genome Annotation (VEGA) database.
(*) Canonical transcript and translation forms.
Information from other databases [+]
- Gene info from HGNC [?] :6881
- Gene related info from GeneCards [?] : MAPK8
- Ensembl genome browser [?] : ENSG00000107643
- Expression info from Arrayexpress [?] : ENSG00000107643
- Protein expression from Protein Atlas: [?] ENSG00000107643
- Community gene edition from Wikigenes: [?] 5599
- OMIM gene information: 601158
- OMIM disease information:
Click on [?] for more information.
