NALP12 (Homo sapiens)
Description [+]
- Synonyms: NALP12
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
- Short gene description: NACHT, LRR and PYD domains-containing protein 12 (PYRIN-containing APAF1-like protein 7)(Monarch-1)(Regulated by nitric oxide) [Source:UniProtKB/Swiss-Prot;Acc:P59046]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: NALP12-H_sapiens
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | PAAD_DAPIN | 9 | 91 |
PFAM A | NACHT | 211 | 381 |
Protein sequence [+]
NALP12 | Homo sapiens | 9606 | length:1062
MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
QVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAALCTNPNLIELS
LYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSG
NGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNAL
EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL
GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLW
LLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLC
KRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
QVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAALCTNPNLIELS
LYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSG
NGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNAL
EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL
GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLW
LLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLC
KRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
Structure links:
- Smartdomain prediction information: SM00382
- Smartdomain prediction information: SM00368
- Profile motif and domain profile information: PS50319
- Profile motif and domain profile information: PS50837
- Profile motif and domain profile information: PS50824
- Interpro domain information: P59046
- PFAM domain and domain family information: P59046
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0031953 | negative regulation of protein amino acid autophosphorylation | biological_proccess | IDA |
GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB cascade | biological_proccess | IDA |
GO:0045409 | negative regulation of interleukin-6 biosynthetic process | biological_proccess | IDA |
GO:0050711 | negative regulation of interleukin-1 secretion | biological_proccess | IDA |
GO:0045751 | negative regulation of Toll signaling pathway | biological_proccess | IDA |
GO:0050718 | positive regulation of interleukin-1 beta secretion | biological_proccess | NAS |
GO:0006919 | activation of caspase activity | biological_proccess | NAS |
GO:0008588 | release of cytoplasmic sequestered NF-kappaB | biological_proccess | IDA |
GO:0050729 | positive regulation of inflammatory response | biological_proccess | NAS |
GO:0045381 | regulation of interleukin-18 biosynthetic process | biological_proccess | NAS |
GO:0005524 | ATP binding | mollecular_function | IEA |
GO:0008656 | caspase activator activity | mollecular_function | NAS |
GO:0005515 | protein binding | mollecular_function | ISS |
GO:0000166 | nucleotide binding | mollecular_function | IEA |
GO:0017111 | nucleoside-triphosphatase activity | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IEA |
GO:0005737 | cytoplasm | cell_component | IDA |
Check GO Evidence Codes here
Information from other databases [+]
- Gene info from HGNC [?] :22938
- Gene related info from GeneCards [?] : NALP12
- Ensembl genome browser [?] : ENSG00000142405
- Expression info from Arrayexpress [?] : ENSG00000142405
- Protein expression from Protein Atlas: [?] ENSG00000142405
- Community gene edition from Wikigenes: [?] 91662
Click on [?] for more information.