Apoptosis Database

Description [+]

Synonyms: BCL2L11, BOD, BIML, BIMEL, BIM
Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
Short gene description: Bcl-2-like protein 11 (Bcl2-interacting mediator of cell death) [Source:UniProtKB/Swiss-Prot;Acc:O43521]
Family: Bcl-2 family : BH3-only
Process: apoptosis,
Pathways: intrinsic pathway, pre-mitochondrial signaling events,
Criteria: manually curated
Curator comment:
Mouse ortholog(s): Bcl2l11
WIKI: BCL2L11-H_sapiens

References [+]

Bim: a novel member of the Bcl-2 family that promotes apoptosis.
O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC
Certain members of the Bcl-2 family inhibit apoptosis while others facilitate this physiological process of cell death. An expression screen for proteins that bind to Bcl-2 yielded a small novel protein, denoted Bim, whose only similarity to any known protein is the short (nine amino acid) BH3 motif shared by most Bcl-2 homologues. Bim provokes apoptosis, and the BH3 region is required for Bcl-2 binding and for most of its cytotoxicity. Like Bcl-2, Bim possesses a hydrophobic C-terminus and localizes to intracytoplasmic membranes. Three Bim isoforms, probably generated by alternative splicing, all induce apoptosis, the shortest being the most potent. Wild-type Bcl-2 associates with Bim in vivo and modulates its death function, whereas Bcl-2 mutants that lack survival function do neither. Significantly, Bcl-xL and Bcl-w, the two closest homologues of Bcl-2, also bind to Bim and inhibit its activity, but more distant viral homologues, adenovirus E1B19K and Epstein-Barr virus BHRF-1, can do neither. Hence, Bim appears to act as a 'death ligand' which can only neutralize certain members of the pro-survival Bcl-2 sub-family. EMBO J. 1998 Jan 15;17(2):384-95.

Bim and Bmf in tissue homeostasis and malignant disease.
Pinon JD, Labi V, Egle A, Villunger A
Among all BH3-only proteins known to date, most information is available on the biological role and function of Bim (Bcl-2 interacting mediator of cell death)/BOD (Bcl-2 related ovarian death agonist), whereas little is still known about its closest relative, Bcl-2 modifying factor (Bmf). Although Bim has been implicated in the regulation of cell death induction in multiple cell types and tissues in response to a large number of stimuli, including growth factor or cytokine deprivation, calcium flux, ligation of antigen receptors on T and B cells, glucocorticoid or loss of adhesion, Bmf seems to play a more restricted role by supporting Bim in some of these cell death processes. This review aims to highlight similarities between Bim and Bmf function in apoptosis signaling and their role in normal development and disease. Oncogene. 2008 Dec;27 Suppl 1:S41-52.

References from Mouse ortholog(s):

Bim: a novel member of the Bcl-2 family that promotes apoptosis.
O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC
Certain members of the Bcl-2 family inhibit apoptosis while others facilitate this physiological process of cell death. An expression screen for proteins that bind to Bcl-2 yielded a small novel protein, denoted Bim, whose only similarity to any known protein is the short (nine amino acid) BH3 motif shared by most Bcl-2 homologues. Bim provokes apoptosis, and the BH3 region is required for Bcl-2 binding and for most of its cytotoxicity. Like Bcl-2, Bim possesses a hydrophobic C-terminus and localizes to intracytoplasmic membranes. Three Bim isoforms, probably generated by alternative splicing, all induce apoptosis, the shortest being the most potent. Wild-type Bcl-2 associates with Bim in vivo and modulates its death function, whereas Bcl-2 mutants that lack survival function do neither. Significantly, Bcl-xL and Bcl-w, the two closest homologues of Bcl-2, also bind to Bim and inhibit its activity, but more distant viral homologues, adenovirus E1B19K and Epstein-Barr virus BHRF-1, can do neither. Hence, Bim appears to act as a 'death ligand' which can only neutralize certain members of the pro-survival Bcl-2 sub-family. EMBO J. 1998 Jan 15;17(2):384-95.

Bim and Bmf in tissue homeostasis and malignant disease.
Pinon JD, Labi V, Egle A, Villunger A
Among all BH3-only proteins known to date, most information is available on the biological role and function of Bim (Bcl-2 interacting mediator of cell death)/BOD (Bcl-2 related ovarian death agonist), whereas little is still known about its closest relative, Bcl-2 modifying factor (Bmf). Although Bim has been implicated in the regulation of cell death induction in multiple cell types and tissues in response to a large number of stimuli, including growth factor or cytokine deprivation, calcium flux, ligation of antigen receptors on T and B cells, glucocorticoid or loss of adhesion, Bmf seems to play a more restricted role by supporting Bim in some of these cell death processes. This review aims to highlight similarities between Bim and Bmf function in apoptosis signaling and their role in normal development and disease. Oncogene. 2008 Dec;27 Suppl 1:S41-52.

Bim and Bmf in tissue homeostasis and malignant disease.
Pinon JD, Labi V, Egle A, Villunger A
Among all BH3-only proteins known to date, most information is available on the biological role and function of Bim (Bcl-2 interacting mediator of cell death)/BOD (Bcl-2 related ovarian death agonist), whereas little is still known about its closest relative, Bcl-2 modifying factor (Bmf). Although Bim has been implicated in the regulation of cell death induction in multiple cell types and tissues in response to a large number of stimuli, including growth factor or cytokine deprivation, calcium flux, ligation of antigen receptors on T and B cells, glucocorticoid or loss of adhesion, Bmf seems to play a more restricted role by supporting Bim in some of these cell death processes. This review aims to highlight similarities between Bim and Bmf function in apoptosis signaling and their role in normal development and disease. Oncogene. 2008 Dec;27 Suppl 1:S41-52.

Structure & Sequence [+]

Source	Domain Name	Start	End
PFAM A	Bim_N	4	40
PFAM A	Bclx_interact	131	167

Evolution [+]

Name	Relationship	Species
BCL2L11	orthology	Chimpanzee
NP_001068778.1	orthology	Cow
BCL2L11	orthology	Dog
BCL2L11	orthology	Gorilla
BCL2L11	orthology	Horse
BCL2L11	orthology	Macaca
BCL2L11	orthology	Monodelphis
Bcl2l11	orthology	Mouse
BCL2L11	orthology	Orangutan
BCL2L11	orthology	Ornithorhynchus
BCL2L11	orthology	Rabbit
BIM_RAT	orthology	Rat

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0001782	B cell homeostasis	biological_proccess	IEA
GO:0001783	B cell apoptosis	biological_proccess	IEA
GO:0001822	kidney development	biological_proccess	IEA
GO:0007160	cell-matrix adhesion	biological_proccess	IEA
GO:0007283	spermatogenesis	biological_proccess	IEA
GO:0008584	male gonad development	biological_proccess	IEA
GO:0009791	post-embryonic development	biological_proccess	IEA
GO:0030879	mammary gland development	biological_proccess	IEA
GO:0042475	odontogenesis of dentine-containing tooth	biological_proccess	IEA
GO:0043029	T cell homeostasis	biological_proccess	IEA
GO:0043583	ear development	biological_proccess	IEA
GO:0046620	regulation of organ growth	biological_proccess	IEA
GO:0048536	spleen development	biological_proccess	IEA
GO:0048563	post-embryonic organ morphogenesis	biological_proccess	IEA
GO:0001701	in utero embryonic development	biological_proccess	IEA
GO:0002262	myeloid cell homeostasis	biological_proccess	IEA
GO:0035148	lumen formation	biological_proccess	IEA
GO:0048070	regulation of pigmentation during development	biological_proccess	IEA
GO:0048538	thymus development	biological_proccess	IEA
GO:0008633	activation of pro-apoptotic gene products	biological_proccess	EXP
GO:0006917	induction of apoptosis	biological_proccess	TAS
GO:0006915	apoptosis	biological_proccess	IEA
GO:0048066	pigmentation during development	biological_proccess	IEA
GO:0043065	positive regulation of apoptosis	biological_proccess	IEA
GO:0001776	leukocyte homeostasis	biological_proccess	IEA
GO:0002260	lymphocyte homeostasis	biological_proccess	IEA
GO:0005515	protein binding	mollecular_function	IPI
GO:0008017	microtubule binding	mollecular_function	IEA
GO:0005515	protein binding	mollecular_function	IEA
GO:0000300	peripheral to membrane of membrane fraction	cell_component	IEA
GO:0005737	cytoplasm	cell_component	IEA
GO:0005741	mitochondrial outer membrane	cell_component	EXP
GO:0005829	cytosol	cell_component	EXP
GO:0005886	plasma membrane	cell_component	EXP
GO:0005739	mitochondrion	cell_component	IEA
GO:0043231	intracellular membrane-bounded organelle	cell_component	IEA

Check GO Evidence Codes here

Curated Isoforms [+]

Transcript	Translation
OTTHUMT00000254022 *	OTTHUMP00000161927 *
OTTHUMT00000254023	OTTHUMP00000204247
OTTHUMT00000314289	OTTHUMP00000204248
OTTHUMT00000314290	OTTHUMP00000195502
OTTHUMT00000314291	OTTHUMP00000204249
OTTHUMT00000314292	OTTHUMP00000204250
OTTHUMT00000314293	OTTHUMP00000204251
OTTHUMT00000314294	OTTHUMP00000204252
OTTHUMT00000314295	OTTHUMP00000204253
OTTHUMT00000317475	OTTHUMP00000197013
OTTHUMT00000331936	OTTHUMP00000204243
OTTHUMT00000331937	OTTHUMP00000204244
OTTHUMT00000331938	OTTHUMP00000204245
OTTHUMT00000331939	OTTHUMP00000204246

Information from other databases [+]

Gene related links:

Gene info from HGNC [?] :994
Gene related info from GeneCards [?] : BCL2L11
Ensembl genome browser [?] : ENSG00000153094
Expression info from Arrayexpress [?] : ENSG00000153094
Protein expression from Protein Atlas: [?] ENSG00000153094
Community gene edition from Wikigenes: [?] 10018

Protein related links:

Uniprot protein info: O43521
PIR protein info: O43521
Protein interactions from IntAct: O43521

Gene and disease information from OMIM: (For a full disease description table, click here.)

OMIM gene information: 603827
OMIM disease information:

Other links

entrezgene: 10018
refseq_dna: NM_207002
refseq_dna: NM_006538
refseq_dna: NM_138621
refseq_peptide: NP_996885
refseq_peptide: NP_006529
refseq_peptide: NP_619527

Click on [?] for more information.

BCL2L11 (Homo sapiens)