INSR (Monodelphis domestica)

Description [+]

Synonyms: INSR
Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Metatheria; Monodelphis domestica
Short gene description: Insulin receptor Precursor (IR)(EC 2.7.10.1)(CD220 antigen) [Contains Insulin receptor subunit alpha;Insulin receptor subunit beta] [Source:UniProtKB/Swiss-Prot;Acc:P06213]
Family: Null
Process:
Pathways:
Criteria: homology search
Curator comment: Null
WIKI: INSR-M_domestica

Structure & Sequence [+]

Pfam domains: (Pfam is a large collection of protein families.)

Source	Domain Name	Start	End
PFAM A	Recep_L_domain	19	131
PFAM A	Furin-like	146	307
PFAM A	Recep_L_domain	325	440
PFAM A	Pkinase	996	1263
PFAM A	Pkinase_Tyr	996	1263

Protein sequence [+]

Structure links:

Smartdomain prediction information: SM00261
Smartdomain prediction information: SM00060
Smartdomain prediction information: SM00220
Smartdomain prediction information: SM00219
Prosite motif and domain information: PS00107
Prosite motif and domain information: PS00109
Prosite motif and domain information: PS00239

Evolution [+]

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0006468	protein amino acid phosphorylation	biological_proccess	IEA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological_proccess	IEA
GO:0008284	positive regulation of cell proliferation	biological_proccess	IEA
GO:0045840	positive regulation of mitosis	biological_proccess	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	biological_proccess	IEA
GO:0000187	activation of MAPK activity	biological_proccess	IEA
GO:0001934	positive regulation of protein amino acid phosphorylation	biological_proccess	IEA
GO:0032148	activation of protein kinase B activity	biological_proccess	IEA
GO:0046326	positive regulation of glucose import	biological_proccess	IEA
GO:0008286	insulin receptor signaling pathway	biological_proccess	IEA
GO:0046777	protein amino acid autophosphorylation	biological_proccess	IEA
GO:0003007	heart morphogenesis	biological_proccess	IEA
GO:0045725	positive regulation of glycogen biosynthetic process	biological_proccess	IEA
GO:0043410	positive regulation of MAPKKK cascade	biological_proccess	IEA
GO:0042593	glucose homeostasis	biological_proccess	IEA
GO:0045740	positive regulation of DNA replication	biological_proccess	IEA
GO:0051897	positive regulation of protein kinase B signaling cascade	biological_proccess	IEA
GO:0030335	positive regulation of cell migration	biological_proccess	IEA
GO:0045429	positive regulation of nitric oxide biosynthetic process	biological_proccess	IEA
GO:0060267	positive regulation of respiratory burst	biological_proccess	IEA
GO:0032583	regulation of gene-specific transcription	biological_proccess	IEA
GO:0045821	positive regulation of glycolysis	biological_proccess	IEA
GO:0045995	regulation of embryonic development	biological_proccess	IEA
GO:0051290	protein heterotetramerization	biological_proccess	IEA
GO:0019087	transformation of host cell by virus	biological_proccess	IEA
GO:0048639	positive regulation of developmental growth	biological_proccess	IEA
GO:0009887	organ morphogenesis	biological_proccess	IEA
GO:0030238	male sex determination	biological_proccess	IEA
GO:0004672	protein kinase activity	mollecular_function	IEA
GO:0005524	ATP binding	mollecular_function	IEA
GO:0004713	protein tyrosine kinase activity	mollecular_function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	mollecular_function	IEA
GO:0004674	protein serine/threonine kinase activity	mollecular_function	IEA
GO:0005525	GTP binding	mollecular_function	IEA
GO:0031995	insulin-like growth factor II binding	mollecular_function	IEA
GO:0005159	insulin-like growth factor receptor binding	mollecular_function	IEA
GO:0031994	insulin-like growth factor I binding	mollecular_function	IEA
GO:0043559	insulin binding	mollecular_function	IEA
GO:0004716	receptor signaling protein tyrosine kinase activity	mollecular_function	IEA
GO:0043560	insulin receptor substrate binding	mollecular_function	IEA
GO:0051425	PTB domain binding	mollecular_function	IEA
GO:0042169	SH2 domain binding	mollecular_function	IEA
GO:0043548	phosphoinositide 3-kinase binding	mollecular_function	IEA
GO:0005009	insulin receptor activity	mollecular_function	IEA
GO:0016020	membrane	cell_component	IEA
GO:0005792	microsome	cell_component	IEA
GO:0005901	caveola	cell_component	IEA
GO:0005899	insulin receptor complex	cell_component	IEA
GO:0005886	plasma membrane	cell_component	IEA

Check GO Evidence Codes here

Information from other databases [+]