BID (Mus musculus)

Description [+]

Synonyms: BID, BID, BH3 INTERACTING DOMAIN DEATH AGONIST
Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Rodentia; Mus musculus
Short gene description: BH3 interacting domain death agonist Gene [Source:MGI (curated);Acc:Bid-001]
Family: Bcl-2 family : BH3-only
Process: apoptosis,
Pathways: extrinsic pathway,
Criteria: manually curated
Curator comment:
Human ortholog(s): BID
WIKI: BID-M_musculus

References [+]

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis.
Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B, Roth KA, Korsmeyer SJ
The protein Bid is a participant in the pathway that leads to cell death (apoptosis), mediating the release of cytochrome c from mitochondria in response to signals from 'death' receptors known as TNFR1/Fas on the cell surface. It is a member of the proapoptotic Bcd-2 family and is activated as a result of its cleavage by caspase 8, one of a family of proteolytic cell-death proteins. To investigate the role of Bid in vivo, we have generated mice deficient for Bid. We find that when these mice are injected with an antibody directed against Fas, they nearly all survive, whereas wild-type mice die from hepatocellular apoptosis and haemorrhagic necrosis. About half of the Bid-deficient animals had no apparent liver injury and showed no evidence of activation of the effector caspases 3 and 7, although the initiator caspase 8 had been activated. Other Bid-deficient mice survived with only moderate damage: all three caspases (8 and 37) were activated but their cell nuclei were intact and no mitochondrial cytochrome c was released. We also investigated the effects of Bid deficiency in cultured cells treated with anti-Fas antibody (hepatocytes and thymocytes) or with TNFalpha. (fibroblasts). In these Bid-/- cells, mitochondrial dysfunction was delayed, cytochrome c was not released, effector caspase activity was reduced and the cleavage of apoptosis substrates was altered. This loss-of-function model indicates that Bid is a critical substrate in vivo for signalling by death-receptor agonists, which mediates a mitochondrial amplification loop that is essential for the apoptosis of selected cells. Nature. 1999 Aug 26;400(6747):886-91.

References from Human ortholog(s):

BID: a novel BH3 domain-only death agonist.
Wang K, Yin XM, Chao DT, Milliman CL, Korsmeyer SJ
The BCL-2 family of proteins consists of both antagonists (e.g., BCL-2) and agonists (e.g., BAX) that regulate apoptosis and compete through dimerization. The BH1 and BH2 domains of BCL-2 are required to heterodimerize with BAX and to repress cell death; conversely, the BH3 domain of BAX is required to heterodimerize with BCL-2 and to promote cell death. To extend this pathway, we used interactive cloning to identify Bid, which encodes a novel death agonist that heterodimerizes with either agonists (BAX) or antagonists (BCL-2). BID possesses only the BH3 domain, lacks a carboxy-terminal signal-anchor segment, and is found in both cytosolic and membrane locations. BID counters the protective effect of BCL-2. Moreover, expression of BID, without another death stimulus, induces ICE-like proteases and apoptosis. Mutagenesis revealed that an intact BH3 domain of BID was required to bind the BH1 domain of either BCL-2 or BAX. A BH3 mutant of BID that still heterodimerized with BCL-2 failed to promote apoptosis, dissociating these activities. In contrast, the only BID BH3 mutant that retained death promoting activity interacted with BAX, but not BCL-2. This BH3-only molecule supports BH3 as a death domain and favors a model in which BID represents a death ligand for the membrane-bound receptor BAX. Genes Dev. 1996 Nov 15;10(22):2859-69.

Structure & Sequence [+]

Source	Domain Name	Start	End
PFAM A	BID	1	195

Evolution [+]

View protein alignment and tree with Jalview:

Explore tree at phylomeDB: Click here.

Homologs list [+]

Name	Relationship	Species
BID_CHICK	orthology	Chicken
BID	orthology	Chimpanzee
NP_001068914.1	orthology	Cow
NP_001068914.1	orthology	Cow
BID	orthology	Dog
BID	orthology	Gorilla
BID	orthology	Horse
BID	orthology	Human
BID	orthology	Lyzard
BID	orthology	Macaca
BID	orthology	Monodelphis
P_pygmaeus_ENSPPYP00000012899	orthology	Orangutan
Q5R7P9_PONPY	orthology	Orangutan
BID	orthology	Ornithorhynchus
BID	orthology	Rabbit
Bid	orthology	Rat
X_tropicalis_ENSXETP00000056482	orthology	Xenopus
X_tropicalis_ENSXETP00000056472	orthology	Xenopus
BID	orthology	Zebra finch

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Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0001836	release of cytochrome c from mitochondria	biological_proccess	IMP
GO:0006626	protein targeting to mitochondrion	biological_proccess	IMP
GO:0043065	positive regulation of apoptosis	biological_proccess	IEA
GO:0046902	regulation of mitochondrial membrane permeability	biological_proccess	IGI
GO:0006915	apoptosis	biological_proccess	IDA
GO:0042981	regulation of apoptosis	biological_proccess	RCA
GO:0001836	release of cytochrome c from mitochondria	biological_proccess	IEA
GO:0005515	protein binding	mollecular_function	IPI
GO:0005737	cytoplasm	cell_component	IEA
GO:0005739	mitochondrion	cell_component	IDA
GO:0005829	cytosol	cell_component	IDA
GO:0016020	membrane	cell_component	IEA
GO:0031966	mitochondrial membrane	cell_component	IEA

Check GO Evidence Codes here

KEGG Pathways [+]

Curated Isoforms [+]

Transcript	Translation
OTTMUST00000059168 *	OTTMUSP00000028756 *
OTTMUST00000059169
OTTMUST00000059170	OTTMUSP00000028757

Information from other databases [+]

Gene related links:

Gene info from MGI [?] MGI:108093
Ensembl genome browser [?] : ENSMUSG00000004446
Expression info from Arrayexpress [?] : ENSMUSG00000004446
Protein expression from Protein Atlas: [?] ENSMUSG00000004446
Community gene edition from Wikigenes: [?] 12122

Protein related links:

Uniprot protein info: P70444
PIR protein info: P70444
Protein interactions from IntAct: P70444

Other links

entrezgene: 12122
refseq_dna: NM_007544
refseq_peptide: NP_031570

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