Apoptosis Database

Description [+]

Synonyms: NLRP3, NLRP3, NLR FAMILY, PYRIN DOMAIN CONTAINING 3
Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Rodentia; Mus musculus
Short gene description: NACHT, LRR and PYD domains-containing protein 3 (Cold autoinflammatory syndrome 1 protein homolog)(Cryopyrin)(PYRIN-containing APAF1-like protein 1)(Mast cell maturation-associated-inducible protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q8R4B8]
Family: other
Process: immunity,
Pathways: inflammasome,
Criteria: manually curated
Curator comment:
WIKI: NLRP3-M_musculus

References [+]

NALPs: a novel protein family involved in inflammation.
Tschopp J, Martinon F, Burns K
A newly discovered family of cytoplasmic proteins--the NALPs--has been implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to microbial infection. Like the structurally related apoptotic protease-activating factor-1 (APAF-1), which is responsible for the activation of caspase-9, the NALP1 protein forms a large, signal-induced multiprotein complex, the inflammasome, resulting in the activation of pro-inflammatory caspases. Nat Rev Mol Cell Biol. 2003 Feb;4(2):95-104.

NOD-LRR proteins: role in host-microbial interactions and inflammatory disease.
Inohara, Chamaillard, McDonald C, Nunez G
Nods are cytosolic proteins that contain a nucleotide-binding oligomerization domain (NOD). These proteins include key regulators of apoptosis and pathogen resistance in mammals and plants. A large number of Nods contain leucine-rich repeats (LRRs), hence referred to as NOD-LRR proteins. Genetic variation in several NOD-LRR proteins, including human Nod2, Cryopyrin, and CIITA, as well as mouse Naip5, is associated with inflammatory disease or increased susceptibility to microbial infections. Nod1, Nod2, Cryopyrin, and Ipaf have been implicated in protective immune responses against pathogens. Together with Toll-like receptors, Nod1 and Nod2 appear to play important roles in innate and acquired immunity as sensors of bacterial components. Specifically, Nod1 and Nod2 participate in the signaling events triggered by host recognition of specific motifs in bacterial peptidoglycan and, upon activation, induce the production of proinflammatory mediators. Naip5 is involved in host resistance to Legionella pneumophila through cell autonomous mechanisms, whereas CIITA plays a critical role in antigen presentation and development of antigen-specific T lymphocytes. Thus, NOD-LRR proteins appear to be involved in a diverse array of processes required for host immune reactions against pathogens. Annu Rev Biochem. 2005;74:355-83.

Structure & Sequence [+]

Pfam domains: (Pfam is a large collection of protein families.)

Source	Domain Name	Start	End
PFAM A	PAAD_DAPIN	4	87
PFAM A	NACHT	216	385

Protein sequence [+]

Structure links:

Evolution [+]

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0006919	activation of caspase activity	biological_proccess	IMP
GO:0006954	inflammatory response	biological_proccess	ISS
GO:0032088	negative regulation of NF-kappaB transcription factor activity	biological_proccess	ISS
GO:0032621	interleukin-18 production	biological_proccess	IMP
GO:0042347	negative regulation of NF-kappaB import into nucleus	biological_proccess	ISS
GO:0050701	interleukin-1 secretion	biological_proccess	IMP
GO:0050718	positive regulation of interleukin-1 beta secretion	biological_proccess	ISS
GO:0051607	defense response to virus	biological_proccess	IMP
GO:0006915	apoptosis	biological_proccess	IEA
GO:0006952	defense response	biological_proccess	IEA
GO:0032088	negative regulation of NF-kappaB transcription factor activity	biological_proccess	IEA
GO:0050718	positive regulation of interleukin-1 beta secretion	biological_proccess	IEA
GO:0006954	inflammatory response	biological_proccess	IEA
GO:0043280	positive regulation of caspase activity	biological_proccess	IEA
GO:0042347	negative regulation of NF-kappaB import into nucleus	biological_proccess	IEA
GO:0000166	nucleotide binding	mollecular_function	IEA
GO:0005515	protein binding	mollecular_function	ISS
GO:0005524	ATP binding	mollecular_function	IEA
GO:0003924	GTPase activity	mollecular_function	IEA
GO:0005525	GTP binding	mollecular_function	IEA
GO:0005515	protein binding	mollecular_function	IEA
GO:0005737	cytoplasm	cell_component	IEA

Check GO Evidence Codes here

Curated Isoforms [+]

Transcript	Translation
OTTMUST00000012840 *	OTTMUSP00000005970 *
OTTMUST00000012841	OTTMUSP00000005971

Information from other databases [+]

Gene related links:

Protein related links:

Other links

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NLRP3 (Mus musculus)