TRP53 (Mus musculus)

Description [+]

Synonyms: TRP53, TP53, P53, TUMOR SUPPRESSOR P53, TRP53, CELLULAR TUMOR ANTIGEN P53
Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Rodentia; Mus musculus
Short gene description: transformation related protein 53 Gene [Source:MGI (curated);Acc:Trp53-001]
Family: other
Process: apoptosis,
Pathways: intrinsic pathway, pre-mitochondrial signaling events,
Criteria: manually curated
Curator comment: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.
WIKI: TRP53-M_musculus

References [+]

Blinded by the Light: The Growing Complexity of p53.
Vousden KH, Prives C
While the tumor suppressor functions of p53 have long been recognized, the contribution of p53 to numerous other aspects of disease and normal life is only now being appreciated. This burgeoning range of responses to p53 is reflected by an increasing variety of mechanisms through which p53 can function, although the ability to activate transcription remains key to p53's modus operandi. Control of p53's transcriptional activity is crucial for determining which p53 response is activated, a decision we must understand if we are to exploit efficiently the next generation of drugs that selectively activate or inhibit p53. Cell. 2009 May 1;137(3):413-31.

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents.
Lotem J, Sachs L
Wild-type p53 is a tumor-suppressor gene that can induce cell death by apoptosis when expressed in myeloid leukemic and some other types of tumor cells. However, the question remained as to what extent wild-type p53 is a mediator of apoptosis in normal cells. We have used mice deficient in wild-type p53 to determine whether induction of apoptosis in hematopoietic cells from these p53 deficient mice is defective. We show here that bone marrow myeloid progenitor cells from p53-deficient mice are more resistant to induction of apoptosis when there was only a low concentration of the viability factors granulocyte-macrophage colony-stimulating factor; interleukins-1 alpha, -3, and -6; or stem cell factor; or when apoptosis was induced in these cells by irradiation or heat shock. The loss of one allele of wild-type p53 was sufficient for increased resistance. The higher resistance to apoptosis in p53-deficient mice was also found in irradiated thymocytes, but not in thymocytes treated with dexamethasone or in mature peritoneal granulocytes. The degree of resistance in irradiated myeloid progenitors and thymocytes showed a dosage effect of the number of wild-type p53 genes. The results show that wild-type p53 is involved in the induction of apoptosis by some agents in normal hematopoietic cells. Loss of wild-type p53 can, therefore, contribute to tumor development by decreasing cell death at low concentrations of viability factors and after exposure to a DNA-damaging agent. The results also show that there are wild-type p53-dependent and -independent pathways of normal cell apoptosis. Blood. 1993 Aug 15;82(4):1092-6.

Structure & Sequence [+]

Pfam domains: (Pfam is a large collection of protein families.)

Source	Domain Name	Start	End
PFAM A	P53_TAD	8	32
PFAM A	P53	92	286
PFAM A	P53_tetramer	315	356

Protein sequence [+]

Structure links:

Prosite motif and domain information: PS00348
Interpro domain information: P02340
PFAM domain and domain family information: P02340
Protein 3D structures from PDB: 2IOO 2P52 2IOI 2IOM 2GEQ 1HU8

Evolution [+]

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0000060	protein import into nucleus, translocation	biological_proccess	IDA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological_proccess	IDA
GO:0001701	in utero embryonic development	biological_proccess	IGI
GO:0001836	release of cytochrome c from mitochondria	biological_proccess	IGI
GO:0002309	T cell proliferation during immune response	biological_proccess	IGI
GO:0002326	B cell lineage commitment	biological_proccess	IMP
GO:0002347	response to tumor cell	biological_proccess	IEA
GO:0002360	T cell lineage commitment	biological_proccess	IMP
GO:0006302	double-strand break repair	biological_proccess	IMP
GO:0006917	induction of apoptosis	biological_proccess	IMP
GO:0006974	response to DNA damage stimulus	biological_proccess	IMP
GO:0007369	gastrulation	biological_proccess	IGI
GO:0007406	negative regulation of neuroblast proliferation	biological_proccess	IGI
GO:0007417	central nervous system development	biological_proccess	IGI
GO:0007569	cell aging	biological_proccess	IGI
GO:0008156	negative regulation of DNA replication	biological_proccess	IDA
GO:0009303	rRNA transcription	biological_proccess	IGI
GO:0009651	response to salt stress	biological_proccess	IGI
GO:0009792	embryonic development ending in birth or egg hatching	biological_proccess	IGI
GO:0010165	response to X-ray	biological_proccess	IDA
GO:0010332	response to gamma radiation	biological_proccess	IMP
GO:0030308	negative regulation of cell growth	biological_proccess	IEA
GO:0031571	G1 DNA damage checkpoint	biological_proccess	IMP
GO:0033077	T cell differentiation in the thymus	biological_proccess	IGI
GO:0034644	cellular response to UV	biological_proccess	IGI
GO:0042493	response to drug	biological_proccess	IDA
GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	biological_proccess	IMP
GO:0043066	negative regulation of apoptosis	biological_proccess	IMP
GO:0043525	positive regulation of neuron apoptosis	biological_proccess	IMP
GO:0045786	negative regulation of cell cycle	biological_proccess	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological_proccess	IDA
GO:0046902	regulation of mitochondrial membrane permeability	biological_proccess	IGI
GO:0048147	negative regulation of fibroblast proliferation	biological_proccess	IMP
GO:0051276	chromosome organization	biological_proccess	IGI
GO:0042149	cellular response to glucose starvation	biological_proccess	ISO
GO:0043065	positive regulation of apoptosis	biological_proccess	IGI
GO:0042981	regulation of apoptosis	biological_proccess	ISO
GO:0043523	regulation of neuron apoptosis	biological_proccess	IGI
GO:0051726	regulation of cell cycle	biological_proccess	IMP
GO:0030330	DNA damage response, signal transduction by p53 class mediator	biological_proccess	IGI
GO:0006915	apoptosis	biological_proccess	IGI
GO:0009411	response to UV	biological_proccess	IMP
GO:0006355	regulation of transcription, DNA-dependent	biological_proccess	IDA
GO:0045941	positive regulation of transcription	biological_proccess	IDA
GO:0018144	RNA-protein covalent cross-linking	biological_proccess	IEA
GO:0045893	positive regulation of transcription, DNA-dependent	biological_proccess	IDA
GO:0006350	transcription	biological_proccess	IEA
GO:0008285	negative regulation of cell proliferation	biological_proccess	IGI
GO:0006983	ER overload response	biological_proccess	ISO
GO:0007049	cell cycle	biological_proccess	IEA
GO:0042127	regulation of cell proliferation	biological_proccess	IGI
GO:0045449	regulation of transcription	biological_proccess	IEA
GO:0008104	protein localization	biological_proccess	IEA
GO:0007275	multicellular organismal development	biological_proccess	IEA
GO:0010552	positive regulation of specific transcription from RNA polymerase II promoter	biological_proccess	IEA
GO:0006983	ER overload response	biological_proccess	IEA
GO:0007569	cell aging	biological_proccess	IEA
GO:0006355	regulation of transcription, DNA-dependent	biological_proccess	IEA
GO:0006974	response to DNA damage stimulus	biological_proccess	IEA
GO:0006461	protein complex assembly	biological_proccess	IEA
GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	biological_proccess	IEA
GO:0008635	activation of caspase activity by cytochrome c	biological_proccess	IEA
GO:0006289	nucleotide-excision repair	biological_proccess	IEA
GO:0042149	cellular response to glucose starvation	biological_proccess	IEA
GO:0010332	response to gamma radiation	biological_proccess	IDA
GO:0006917	induction of apoptosis	biological_proccess	IDA
GO:0051453	regulation of intracellular pH	biological_proccess	IEA
GO:0003700	transcription factor activity	mollecular_function	IDA
GO:0005515	protein binding	mollecular_function	IPI
GO:0008270	zinc ion binding	mollecular_function	IEA
GO:0046872	metal ion binding	mollecular_function	IEA
GO:0003677	DNA binding	mollecular_function	IDA
GO:0003682	chromatin binding	mollecular_function	ISO
GO:0046982	protein heterodimerization activity	mollecular_function	IEA
GO:0005524	ATP binding	mollecular_function	IEA
GO:0003700	transcription factor activity	mollecular_function	IEA
GO:0008134	transcription factor binding	mollecular_function	IEA
GO:0019899	enzyme binding	mollecular_function	IEA
GO:0010843	promoter binding	mollecular_function	IEA
GO:0047485	protein N-terminus binding	mollecular_function	IEA
GO:0051087	chaperone binding	mollecular_function	IEA
GO:0003682	chromatin binding	mollecular_function	IEA
GO:0005507	copper ion binding	mollecular_function	IEA
GO:0000739	DNA strand annealing activity	mollecular_function	IEA
GO:0003677	DNA binding	mollecular_function	IEA
GO:0005634	nucleus	cell_component	IDA
GO:0005657	replication fork	cell_component	IDA
GO:0005737	cytoplasm	cell_component	IDA
GO:0005829	cytosol	cell_component	IDA
GO:0005783	endoplasmic reticulum	cell_component	IEA
GO:0005737	cytoplasm	cell_component	IEA
GO:0005634	nucleus	cell_component	IEA
GO:0016605	PML body	cell_component	IEA
GO:0005730	nucleolus	cell_component	IEA
GO:0016363	nuclear matrix	cell_component	IEA
GO:0005739	mitochondrion	cell_component	IEA
GO:0005669	transcription factor TFIID complex	cell_component	IEA
GO:0005654	nucleoplasm	cell_component	IEA
GO:0005626	insoluble fraction	cell_component	IEA

Check GO Evidence Codes here

KEGG Pathways [+]

KEGG report for Trp53: 22059

KEGG pathways for Trp53:

mmu04010: MAPK signaling pathway (entry, map)

mmu04110: Cell cycle (entry, map)

mmu04115: p53 signaling pathway (entry, map)

mmu04210: Apoptosis (entry, map)

mmu04310: Wnt signaling pathway (entry, map)

mmu05030: Amyotrophic lateral sclerosis (ALS) (entry, map)

mmu05040: Huntington's disease (entry, map)

mmu05210: Colorectal cancer (entry, map)

mmu05212: Pancreatic cancer (entry, map)

mmu05213: Endometrial cancer (entry, map)

mmu05214: Glioma (entry, map)

mmu05215: Prostate cancer (entry, map)

mmu05216: Thyroid cancer (entry, map)

mmu05217: Basal cell carcinoma (entry, map)

mmu05218: Melanoma (entry, map)

mmu05219: Bladder cancer (entry, map)

mmu05220: Chronic myeloid leukemia (entry, map)

mmu05222: Small cell lung cancer (entry, map)

mmu05223: Non-small cell lung cancer (entry, map)

Information from other databases [+]

Gene related links:

Gene info from MGI [?] MGI:98834
Ensembl genome browser [?] : ENSMUSG00000059552
Expression info from Arrayexpress [?] : ENSMUSG00000059552
Protein expression from Protein Atlas: [?] ENSMUSG00000059552
Community gene edition from Wikigenes: [?] 22059

Protein related links:

Uniprot protein info: P02340
PIR protein info: P02340
Protein interactions from IntAct: P02340

Other links

entrezgene: 22059
refseq_dna: NM_011640
refseq_dna: NM_001127233
refseq_peptide: NP_035770
refseq_peptide: NP_001120705

Click on [?] for more information.