BCL2 (Rattus norvegicus)

Description [+]

Synonyms: BCL2
Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Rodentia; Rattus norvegicus
Short gene description: Apoptosis regulator Bcl-2. [Source:UniProtKB/Swiss-Prot;Acc:P49950]
Family: Null
Process:
Pathways:
Criteria: homology search
Curator comment: Null
WIKI: BCL2-R_norvegicus

Structure & Sequence [+]

Pfam domains: (Pfam is a large collection of protein families.)

Source	Domain Name	Start	End
PFAM A	BH4	7	33
PFAM A	Bcl-2	94	192

Protein sequence [+]

Structure links:

Smartdomain prediction information: SM00265
Smartdomain prediction information: SM00337
Prosite motif and domain information: PS01080
Prosite motif and domain information: PS01258
Prosite motif and domain information: PS01259
Prosite motif and domain information: PS01260
Interpro domain information: P49950
PFAM domain and domain family information: P49950

Evolution [+]

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0000082	G1/S transition of mitotic cell cycle	biological_proccess	IEA
GO:0000902	cell morphogenesis	biological_proccess	IEA
GO:0001541	ovarian follicle development	biological_proccess	IEA
GO:0001657	ureteric bud development	biological_proccess	IEA
GO:0001658	ureteric bud branching	biological_proccess	IEA
GO:0001662	behavioral fear response	biological_proccess	IEA
GO:0001666	response to hypoxia	biological_proccess	IEP
GO:0001782	B cell homeostasis	biological_proccess	IEA
GO:0001836	release of cytochrome c from mitochondria	biological_proccess	ISS
GO:0001952	regulation of cell-matrix adhesion	biological_proccess	IEA
GO:0002320	lymphoid progenitor cell differentiation	biological_proccess	IEA
GO:0002326	B cell lineage commitment	biological_proccess	IEA
GO:0002360	T cell lineage commitment	biological_proccess	IEA
GO:0002520	immune system development	biological_proccess	IEA
GO:0003014	renal system process	biological_proccess	IEA
GO:0006470	protein amino acid dephosphorylation	biological_proccess	IEA
GO:0006582	melanin metabolic process	biological_proccess	IEA
GO:0006800	oxygen and reactive oxygen species metabolic process	biological_proccess	IEA
GO:0006808	regulation of nitrogen utilization	biological_proccess	IEA
GO:0006916	anti-apoptosis	biological_proccess	IEA
GO:0006979	response to oxidative stress	biological_proccess	IEA
GO:0007015	actin filament organization	biological_proccess	IEA
GO:0007569	cell aging	biological_proccess	IEA
GO:0007584	response to nutrient	biological_proccess	IEP
GO:0008219	cell death	biological_proccess	IEA
GO:0008284	positive regulation of cell proliferation	biological_proccess	IEA
GO:0008584	male gonad development	biological_proccess	IEA
GO:0009408	response to heat	biological_proccess	IEP
GO:0009605	response to external stimulus	biological_proccess	IEA
GO:0009636	response to toxin	biological_proccess	IEA
GO:0009791	post-embryonic development	biological_proccess	IEA
GO:0009887	organ morphogenesis	biological_proccess	IEA
GO:0010035	response to inorganic substance	biological_proccess	IEP
GO:0010044	response to aluminum ion	biological_proccess	IEP
GO:0010224	response to UV-B	biological_proccess	IEA
GO:0010332	response to gamma radiation	biological_proccess	IEA
GO:0010468	regulation of gene expression	biological_proccess	IEA
GO:0010523	negative regulation of calcium ion transport into cytosol	biological_proccess	IEA
GO:0010559	regulation of glycoprotein biosynthetic process	biological_proccess	IEA
GO:0014031	mesenchymal cell development	biological_proccess	IEA
GO:0014042	positive regulation of neuron maturation	biological_proccess	IEA
GO:0014911	positive regulation of smooth muscle cell migration	biological_proccess	IEA
GO:0016337	cell-cell adhesion	biological_proccess	IEA
GO:0018107	peptidyl-threonine phosphorylation	biological_proccess	IEA
GO:0021747	cochlear nucleus development	biological_proccess	IEA
GO:0022612	gland morphogenesis	biological_proccess	IEA
GO:0030097	hemopoiesis	biological_proccess	IEA
GO:0030279	negative regulation of ossification	biological_proccess	IEA
GO:0030308	negative regulation of cell growth	biological_proccess	IEA
GO:0030336	negative regulation of cell migration	biological_proccess	IEA
GO:0031000	response to caffeine	biological_proccess	IEP
GO:0031069	hair follicle morphogenesis	biological_proccess	IEA
GO:0031103	axon regeneration	biological_proccess	IEA
GO:0031647	regulation of protein stability	biological_proccess	IEA
GO:0032469	endoplasmic reticulum calcium ion homeostasis	biological_proccess	IEA
GO:0032835	glomerulus development	biological_proccess	IEA
GO:0032880	regulation of protein localization	biological_proccess	IEA
GO:0033033	negative regulation of myeloid cell apoptosis	biological_proccess	IEA
GO:0033077	T cell differentiation in the thymus	biological_proccess	IEA
GO:0033138	positive regulation of peptidyl-serine phosphorylation	biological_proccess	IEA
GO:0033689	negative regulation of osteoblast proliferation	biological_proccess	IEA
GO:0034097	response to cytokine stimulus	biological_proccess	IEA
GO:0035094	response to nicotine	biological_proccess	IEP
GO:0035265	organ growth	biological_proccess	IEA
GO:0040018	positive regulation of multicellular organism growth	biological_proccess	IEA
GO:0042493	response to drug	biological_proccess	IEA
GO:0042542	response to hydrogen peroxide	biological_proccess	IEA
GO:0043029	T cell homeostasis	biological_proccess	IEA
GO:0043085	positive regulation of catalytic activity	biological_proccess	IEA
GO:0043375	CD8-positive, alpha-beta T cell lineage commitment	biological_proccess	IEA
GO:0043434	response to peptide hormone stimulus	biological_proccess	IEP
GO:0043524	negative regulation of neuron apoptosis	biological_proccess	IEA
GO:0043583	ear development	biological_proccess	IEA
GO:0043627	response to estrogen stimulus	biological_proccess	IEP
GO:0045069	regulation of viral genome replication	biological_proccess	IEA
GO:0045471	response to ethanol	biological_proccess	IEP
GO:0045636	positive regulation of melanocyte differentiation	biological_proccess	IEA
GO:0045930	negative regulation of mitotic cell cycle	biological_proccess	IEA
GO:0046671	negative regulation of retinal cell programmed cell death	biological_proccess	IEA
GO:0046688	response to copper ion	biological_proccess	IEP
GO:0046902	regulation of mitochondrial membrane permeability	biological_proccess	ISS
GO:0048041	focal adhesion formation	biological_proccess	IEA
GO:0048087	positive regulation of pigmentation during development	biological_proccess	IEA
GO:0048536	spleen development	biological_proccess	IEA
GO:0048538	thymus development	biological_proccess	IEA
GO:0048547	gut morphogenesis	biological_proccess	IEA
GO:0048589	developmental growth	biological_proccess	IEA
GO:0048599	oocyte development	biological_proccess	IEA
GO:0048743	positive regulation of skeletal muscle fiber development	biological_proccess	IEA
GO:0048753	pigment granule organization	biological_proccess	IEA
GO:0048873	homeostasis of number of cells within a tissue	biological_proccess	IEA
GO:0051412	response to corticosterone stimulus	biological_proccess	IEP
GO:0051593	response to folic acid	biological_proccess	IEP
GO:0051726	regulation of cell cycle	biological_proccess	IEA
GO:0051789	response to protein stimulus	biological_proccess	IEA
GO:0051881	regulation of mitochondrial membrane potential	biological_proccess	ISS
GO:0042981	regulation of apoptosis	biological_proccess	IEA
GO:0010039	response to iron ion	biological_proccess	IEA
GO:0043497	regulation of protein heterodimerization activity	biological_proccess	IEA
GO:0070059	apoptosis in response to endoplasmic reticulum stress	biological_proccess	IEA
GO:0035094	response to nicotine	biological_proccess	IEA
GO:0051607	defense response to virus	biological_proccess	IEA
GO:0043496	regulation of protein homodimerization activity	biological_proccess	IEA
GO:0051924	regulation of calcium ion transport	biological_proccess	IEA
GO:0042100	B cell proliferation	biological_proccess	IEA
GO:0032848	negative regulation of cellular pH reduction	biological_proccess	IEA
GO:0006915	apoptosis	biological_proccess	IEA
GO:0008285	negative regulation of cell proliferation	biological_proccess	IEA
GO:0007409	axonogenesis	biological_proccess	IEA
GO:0008283	cell proliferation	biological_proccess	IEA
GO:0030183	B cell differentiation	biological_proccess	IEA
GO:0051384	response to glucocorticoid stimulus	biological_proccess	IEA
GO:0048066	pigmentation during development	biological_proccess	IEA
GO:0006874	cellular calcium ion homeostasis	biological_proccess	IEA
GO:0001822	kidney development	biological_proccess	IEA
GO:0043066	negative regulation of apoptosis	biological_proccess	IEA
GO:0016049	cell growth	biological_proccess	IEA
GO:0001503	ossification	biological_proccess	IEA
GO:0030318	melanocyte differentiation	biological_proccess	IEA
GO:0051881	regulation of mitochondrial membrane potential	biological_proccess	IEA
GO:0051402	neuron apoptosis	biological_proccess	IEA
GO:0050790	regulation of catalytic activity	biological_proccess	IEA
GO:0042221	response to chemical stimulus	biological_proccess	IEA
GO:0048545	response to steroid hormone stimulus	biological_proccess	IEA
GO:0001101	response to acid	biological_proccess	IEA
GO:0018105	peptidyl-serine phosphorylation	biological_proccess	IEA
GO:0001836	release of cytochrome c from mitochondria	biological_proccess	IEA
GO:0048070	regulation of pigmentation during development	biological_proccess	IEA
GO:0001656	metanephros development	biological_proccess	IEA
GO:0030217	T cell differentiation	biological_proccess	IEA
GO:0040007	growth	biological_proccess	IEA
GO:0046902	regulation of mitochondrial membrane permeability	biological_proccess	IEA
GO:0001776	leukocyte homeostasis	biological_proccess	IEA
GO:0043067	regulation of programmed cell death	biological_proccess	IEA
GO:0002260	lymphocyte homeostasis	biological_proccess	IEA
GO:0008134	transcription factor binding	mollecular_function	IEA
GO:0016563	transcription activator activity	mollecular_function	IEA
GO:0046982	protein heterodimerization activity	mollecular_function	IEA
GO:0042803	protein homodimerization activity	mollecular_function	IEA
GO:0002020	protease binding	mollecular_function	IEA
GO:0051434	BH3 domain binding	mollecular_function	IEA
GO:0005515	protein binding	mollecular_function	IEA
GO:0000159	protein phosphatase type 2A complex	cell_component	IEA
GO:0005622	intracellular	cell_component	IEA
GO:0005624	membrane fraction	cell_component	IEA
GO:0005634	nucleus	cell_component	IEA
GO:0005737	cytoplasm	cell_component	IEA
GO:0005739	mitochondrion	cell_component	IEA
GO:0005741	mitochondrial outer membrane	cell_component	IEA
GO:0005783	endoplasmic reticulum	cell_component	IEA
GO:0005789	endoplasmic reticulum membrane	cell_component	IEA
GO:0005792	microsome	cell_component	IEA
GO:0005829	cytosol	cell_component	IEA
GO:0005955	calcineurin complex	cell_component	IEA
GO:0016020	membrane	cell_component	IEA
GO:0016021	integral to membrane	cell_component	IEA
GO:0031965	nuclear membrane	cell_component	IEA
GO:0043209	myelin sheath	cell_component	IEA
GO:0031966	mitochondrial membrane	cell_component	IEA

Check GO Evidence Codes here

KEGG Pathways [+]

Information from other databases [+]

Gene related links:

Ensembl genome browser [?] : ENSRNOG00000002791
Expression info from Arrayexpress [?] : ENSRNOG00000002791
Protein expression from Protein Atlas: [?] ENSRNOG00000002791

Protein related links:

Uniprot protein info: P49950
PIR protein info: P49950
Protein interactions from IntAct: P49950

Other links

entrezgene: 24224
refseq_dna: NM_016993
refseq_peptide: NP_058689

Click on [?] for more information.