TLR4 (Rattus norvegicus)
Description [+]
- Synonyms: TLR4
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Rodentia; Rattus norvegicus
- Short gene description: Toll-like receptor 4 precursor (Toll4) (CD284 antigen). [Source:UniProtKB/Swiss-Prot;Acc:Q9QX05]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: TLR4-R_norvegicus
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | TIR | 674 | 812 |
Protein sequence [+]
Tlr4 | Rattus norvegicus | 10116 | length:835
MMPLLHLAGTLIMALFLSCLRPGSLNPCIEVLPNITYQCMDQNLSKIPHDIPYSTKNLDL
SFNPLKILRSYSFSNFSQLQWLDLSRCEIETIEDKAWHGLNQLSTLVLTGNPIKSFSPGS
FSGLTNLENLVAVETKMTSLEGFHIGQLISLKKLNVAHNLIHSFKLPEYFSNLTNLEHVD
LSYNYIQTISVKDLQFLRENPQVNLSLDLSLNPIDSIQAQAFQGIRLHELTLRSNFNSSN
VLKMCLQNMTGLHVHRLILGEFKNERNLESFDRSVMEGLCNVSIDEFRLTYINHFSDDIY
NLNCLANISAMSFTGVHIKHIADVPRHFKWQSLSIIRCHLKPFPKLSLPFLKSWTLTTNR
EDISFGQLALPSLRYLDLSRNAMSFRGCCSYSDFGTNNLKYLDLSFNGVILMSANFMGLE
ELEYLDFQHSTLKKVTEFSVFLSLEKLLYLDISYTNTKIDFDGIFLGLISLNTLKMAGNS
FKDNTLSNVFTNTTNLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQ
LYSLRTLDCSFNRIETSKGILQHFPKSLAVFNLTNNSVACICEYQNFLQWVKDQKMFLVN
VEQMKCASPIDMKASLVLDFTNSTCYIYKTIISVSVVSVLVVATVAFLIYHFYFHLILIA
GCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANI
IQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQ
VELYRLLSRNTYLEWEDNALGRHIFWRRLKKALLDGKALNPDETSEEEQEATTLT
SFNPLKILRSYSFSNFSQLQWLDLSRCEIETIEDKAWHGLNQLSTLVLTGNPIKSFSPGS
FSGLTNLENLVAVETKMTSLEGFHIGQLISLKKLNVAHNLIHSFKLPEYFSNLTNLEHVD
LSYNYIQTISVKDLQFLRENPQVNLSLDLSLNPIDSIQAQAFQGIRLHELTLRSNFNSSN
VLKMCLQNMTGLHVHRLILGEFKNERNLESFDRSVMEGLCNVSIDEFRLTYINHFSDDIY
NLNCLANISAMSFTGVHIKHIADVPRHFKWQSLSIIRCHLKPFPKLSLPFLKSWTLTTNR
EDISFGQLALPSLRYLDLSRNAMSFRGCCSYSDFGTNNLKYLDLSFNGVILMSANFMGLE
ELEYLDFQHSTLKKVTEFSVFLSLEKLLYLDISYTNTKIDFDGIFLGLISLNTLKMAGNS
FKDNTLSNVFTNTTNLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQ
LYSLRTLDCSFNRIETSKGILQHFPKSLAVFNLTNNSVACICEYQNFLQWVKDQKMFLVN
VEQMKCASPIDMKASLVLDFTNSTCYIYKTIISVSVVSVLVVATVAFLIYHFYFHLILIA
GCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANI
IQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQ
VELYRLLSRNTYLEWEDNALGRHIFWRRLKKALLDGKALNPDETSEEEQEATTLT
Structure links:
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0002224 | toll-like receptor signaling pathway | biological_proccess | IDA |
GO:0002282 | microglial cell activation during immune response | biological_proccess | IDA |
GO:0006979 | response to oxidative stress | biological_proccess | IMP |
GO:0007165 | signal transduction | biological_proccess | IEA |
GO:0032497 | detection of lipopolysaccharide | biological_proccess | ISS |
GO:0042742 | defense response to bacterium | biological_proccess | IDA |
GO:0043065 | positive regulation of apoptosis | biological_proccess | IMP |
GO:0045087 | innate immune response | biological_proccess | IEA |
GO:0045471 | response to ethanol | biological_proccess | IMP |
GO:0050729 | positive regulation of inflammatory response | biological_proccess | IMP |
GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | biological_proccess | IDA |
GO:0051092 | positive regulation of NF-kappaB transcription factor activity | biological_proccess | IMP |
GO:0052033 | pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity | biological_proccess | IDA |
GO:0008152 | metabolic process | biological_proccess | IEA |
GO:0032760 | positive regulation of tumor necrosis factor production | biological_proccess | IEA |
GO:0032496 | response to lipopolysaccharide | biological_proccess | IEA |
GO:0032755 | positive regulation of interleukin-6 production | biological_proccess | IEA |
GO:0032874 | positive regulation of stress-activated MAPK cascade | biological_proccess | IEA |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | biological_proccess | IEA |
GO:0046330 | positive regulation of JNK cascade | biological_proccess | IEA |
GO:0070374 | positive regulation of ERK1 and ERK2 cascade | biological_proccess | IEA |
GO:0032609 | interferon-gamma production | biological_proccess | IEA |
GO:0009617 | response to bacterium | biological_proccess | IEA |
GO:0010572 | positive regulation of platelet activation | biological_proccess | IEA |
GO:0002537 | production of nitric oxide during acute inflammatory response | biological_proccess | IEA |
GO:0070430 | positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway | biological_proccess | IEA |
GO:0070434 | positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway | biological_proccess | IEA |
GO:0045084 | positive regulation of interleukin-12 biosynthetic process | biological_proccess | IEA |
GO:0042116 | macrophage activation | biological_proccess | IEA |
GO:0032497 | detection of lipopolysaccharide | biological_proccess | IEA |
GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process | biological_proccess | IEA |
GO:0045416 | positive regulation of interleukin-8 biosynthetic process | biological_proccess | IEA |
GO:0001875 | lipopolysaccharide receptor activity | mollecular_function | ISS |
GO:0004888 | transmembrane receptor activity | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IEA |
GO:0043548 | phosphoinositide 3-kinase binding | mollecular_function | IPI |
GO:0003824 | catalytic activity | mollecular_function | IEA |
GO:0001875 | lipopolysaccharide receptor activity | mollecular_function | IEA |
GO:0005737 | cytoplasm | cell_component | IDA |
GO:0005887 | integral to plasma membrane | cell_component | TAS |
GO:0009986 | cell surface | cell_component | IDA |
GO:0016020 | membrane | cell_component | IEA |
GO:0045121 | membrane raft | cell_component | IDA |
GO:0046696 | lipopolysaccharide receptor complex | cell_component | ISS |
GO:0031224 | intrinsic to membrane | cell_component | IEA |
GO:0005887 | integral to plasma membrane | cell_component | IEA |
GO:0009897 | external side of plasma membrane | cell_component | IEA |
GO:0048471 | perinuclear region of cytoplasm | cell_component | IEA |
Check GO Evidence Codes here
KEGG Pathways [+]
Information from other databases [+]
- Ensembl genome browser [?] : ENSRNOG00000010522
- Expression info from Arrayexpress [?] : ENSRNOG00000010522
- Protein expression from Protein Atlas: [?] ENSRNOG00000010522
Click on [?] for more information.