NOTC2_RAT (Rattus norvegicus)

Description [+]

Synonyms: NOTC2_RAT
Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Rodentia; Rattus norvegicus
Short gene description: Neurogenic locus notch homolog protein 2 Precursor (Notch 2) [Contains Notch 2 extracellular truncation;Notch 2 intracellular domain] [Source:UniProtKB/Swiss-Prot;Acc:Q9QW30]
Family: Null
Process:
Pathways:
Criteria: homology search
Curator comment: Null
WIKI: NOTC2_RAT-R_norvegicus

Structure & Sequence [+]

Protein sequence [+]

NOTC2_RAT | Rattus norvegicus | 10116 | length:2471

MPALRPAALRALLWLWLCGAGPAHALQCRGGQEPCVNEGTCVTYHNGTGYCRCPEGFLGE
YCQHRDPCEKNRCQNGGTCVTQAMLGKATCRCAPGFTGEDCQYSTSHPCFVSRPCQNGGT
CHMLSWDTYECTCQVGFTGKQCQWTDVCLSHPCENGSTCSSVANQFSCRCPAGITGQKCD
ADINECDIPGRCQHGGTCLNLPGSYRCQCPQGFTGQHCDSPYVPCAPSPCVNGGTCRQTG
DFTSECHCLPGFEGSNCERNIDDCPNHKCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVD
ECLLQPNACQNGGTCTNRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASF
SCLCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECA
MANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTC
LCMPGFKGVHCELEVNECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTP
CLNGAKCIDHPNGYECQCATGFTGTLCDENIDNCDPDPCHHGQCQDGIDSYTCICNPGYM
GAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGLNCEINFDDCASNPCLHGACV
DGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINDVNGFRCMCPEGPHHPSCYSQ
VNECLSSPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCNNLVNGYR
CTCKKGFKGYNCQVNIDECASNPCLNQGTCLDDVSGYTCHCMLPYTGKNCQTVLAPCSPN
PCENAAVCKEAPNFESFTCLCAPGWQGQRCTVDVDECVSKPCMNNGICHNTQGSYMCECP
PGFSGMDCEEDINDCLANPCQNGGSCVDKVNTFSCLCLPGFVGDKCQTDMNECLSEPCKN
GGTCSDYVNSYTCTCPAGFHGVHCENNIDECTESSCFNGGTCVDGINSFSCLCPVGFTGP
FCLHDINECSSNPCLNSGTCVDGLGTYRCTCPLGYTGKNCQTLVNLCSPSPCKNKGTCAQ
EKARPRCLCPPGWDGAYCDVLNVSCKAAALQKGVPVEHLCQHSGICINAGNTHHCQCPLG
YTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGG
TCIDLVNHFKCSCPPGTRGLLCEENIDDCAGGPHCLNGGQCVDRIGGYSCRCLPGFAGER
CEGDINECLSNPCSSEGSLDCIQLKNNYQCVCRSAFTGRHCETFLDVCPQKPCLNGGTCA
VASNVPDGFICRCPPGFSGARCQSSCGQVKCRRGEQCVHTASGPHCFCLNRKDCESGCAS
NPCQHGGTCYPQRQPPYYSCRCSPPFWGSHCESYTAPTSTPPATCLSQYCADKARDGICD
EACNSHACQWDGGDCSLTMEDPWANCTSSLRCWEYINNQCDELCNTAECLFDNFECQRNS
KTCKYDKYCADHFKDNHCDKGCNNEECGWDGLDCAADQPENLAEGILVIVVLLPPEQLLQ
DSRSFLRALGTLLHTNLRIKQDSQGALMVYPYYGEKSAAMKKQKVARRSLPDEQEQEIIG
SKVFLEIDNRQCVQDSDQCFKNTDAAAALLASHAIQGTLSYPLVSVVSESEDPRNTPLLY
LLAVAVVIILFLILLGVIMAKRKRKHGFLWLPEGFTLRRDSSNHKRREPVGQDAVGLKNL
SVQVSEANLIGSTTSEHWGDDEGPQPKKAKAEDDEALLSEDDPVDRRPWTQQHLEAADIR
RTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIIT
DLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAA
DAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSA
LHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITD
HMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVLCGPNRSFLSLKHTPMG
KKARRPNTKSTMPTSLPNLAKEAKDVKGSRRKKCLNEKVQLSESSVTLSPVDSLESPHTY
VSDATSSPMITSPGILQASPTPLLAAAPAAPVHAQHALSFSNLHEMQPLAPGASTVLPSV
SQLLSHHHIVPPGSGSAGSLGRLHSVPVPSDWMNRVEMSETQYSEMFGMVLAPAEGTHPG
MAAPQSRAPEGKPIPTQREPLPPIVTFQLIPKGSLAQAAGAPQTQSGCPPAVAGPLPSMY
QIPEMARLPSVAFPPTMMPQQEGQVAQTIVPTYHPFPASVGKYPTPPSQHSYASSNAAER
TPNHGGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGGGGGQRGPGTHMS
EPPHSNMQVYA

BLAST at NCBI | WU-BLAST2 at EBI

Evolution [+]

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0001709	cell fate determination	biological_proccess	IDA
GO:0006350	transcription	biological_proccess	IEA
GO:0006355	regulation of transcription, DNA-dependent	biological_proccess	IEA
GO:0007050	cell cycle arrest	biological_proccess	ISS
GO:0007219	Notch signaling pathway	biological_proccess	IEA
GO:0007275	multicellular organismal development	biological_proccess	IEA
GO:0008285	negative regulation of cell proliferation	biological_proccess	ISS
GO:0009887	organ morphogenesis	biological_proccess	ISS
GO:0016049	cell growth	biological_proccess	ISS
GO:0030154	cell differentiation	biological_proccess	IEA
GO:0042246	tissue regeneration	biological_proccess	IEP
GO:0046579	positive regulation of Ras protein signal transduction	biological_proccess	ISS
GO:0050793	regulation of developmental process	biological_proccess	IEA
GO:0009887	organ morphogenesis	biological_proccess	IEA
GO:0007050	cell cycle arrest	biological_proccess	IEA
GO:0008285	negative regulation of cell proliferation	biological_proccess	IEA
GO:0016049	cell growth	biological_proccess	IEA
GO:0046579	positive regulation of Ras protein signal transduction	biological_proccess	IEA
GO:0007368	determination of left/right symmetry	biological_proccess	IEA
GO:0042060	wound healing	biological_proccess	IEA
GO:0030326	embryonic limb morphogenesis	biological_proccess	IEA
GO:0043065	positive regulation of apoptosis	biological_proccess	IEA
GO:0002011	morphogenesis of an epithelial sheet	biological_proccess	IEA
GO:0004872	receptor activity	mollecular_function	IEA
GO:0005509	calcium ion binding	mollecular_function	IEA
GO:0005515	protein binding	mollecular_function	IDA
GO:0005515	protein binding	mollecular_function	IEA
GO:0005634	nucleus	cell_component	ISS
GO:0005886	plasma membrane	cell_component	IEA
GO:0005887	integral to plasma membrane	cell_component	ISS
GO:0009986	cell surface	cell_component	ISS
GO:0016020	membrane	cell_component	IEA
GO:0016021	integral to membrane	cell_component	IEA
GO:0005634	nucleus	cell_component	IEA
GO:0005887	integral to plasma membrane	cell_component	IEA
GO:0009986	cell surface	cell_component	IEA

Check GO Evidence Codes here

Information from other databases [+]