TRP63 (Rattus norvegicus)

Description [+]

Synonyms: TRP63
Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Rodentia; Rattus norvegicus
Short gene description: Tumor protein 63 (p63) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (Keratinocyte transcription factor KET). [Source:UniProtKB/Swiss-Prot;Acc:Q9JJP6]
Family: Null
Process:
Pathways:
Criteria: homology search
Curator comment: Null
WIKI: TRP63-R_norvegicus

Structure & Sequence [+]

Pfam domains: (Pfam is a large collection of protein families.)

Source	Domain Name	Start	End
PFAM A	P53	163	359
PFAM A	P53_tetramer	391	432
PFAM A	SAM_2	541	607

Protein sequence [+]

Structure links:

Smartdomain prediction information: SM00454
Prosite motif and domain information: PS00348
Interpro domain information: Q9JJP6
PFAM domain and domain family information: Q9JJP6

Evolution [+]

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0001302	replicative cell aging	biological_proccess	IMP
GO:0002347	response to tumor cell	biological_proccess	IEA
GO:0006355	regulation of transcription, DNA-dependent	biological_proccess	IEA
GO:0006915	apoptosis	biological_proccess	IEA
GO:0007219	Notch signaling pathway	biological_proccess	IEA
GO:0007275	multicellular organismal development	biological_proccess	IEA
GO:0030308	negative regulation of cell growth	biological_proccess	IEA
GO:0045449	regulation of transcription	biological_proccess	IEA
GO:0045893	positive regulation of transcription, DNA-dependent	biological_proccess	IEA
GO:0045892	negative regulation of transcription, DNA-dependent	biological_proccess	IEA
GO:0045747	positive regulation of Notch signaling pathway	biological_proccess	IEA
GO:0051289	protein homotetramerization	biological_proccess	IEA
GO:0030154	cell differentiation	biological_proccess	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological_proccess	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological_proccess	IEA
GO:0006917	induction of apoptosis	biological_proccess	IEA
GO:0006916	anti-apoptosis	biological_proccess	IEA
GO:0009887	organ morphogenesis	biological_proccess	IEA
GO:0001501	skeletal system development	biological_proccess	IEA
GO:0002064	epithelial cell development	biological_proccess	IEA
GO:0031069	hair follicle morphogenesis	biological_proccess	IEA
GO:0030326	embryonic limb morphogenesis	biological_proccess	IEA
GO:0030855	epithelial cell differentiation	biological_proccess	IEA
GO:0001942	hair follicle development	biological_proccess	IEA
GO:0042475	odontogenesis of dentine-containing tooth	biological_proccess	IEA
GO:0009954	proximal/distal pattern formation	biological_proccess	IEA
GO:0048745	smooth muscle development	biological_proccess	IEA
GO:0051402	neuron apoptosis	biological_proccess	IEA
GO:0008544	epidermis development	biological_proccess	IEA
GO:0001736	establishment of planar polarity	biological_proccess	IEA
GO:0002053	positive regulation of mesenchymal cell proliferation	biological_proccess	IEA
GO:0007389	pattern specification process	biological_proccess	IEA
GO:0007499	ectoderm and mesoderm interaction	biological_proccess	IEA
GO:0007569	cell aging	biological_proccess	IEA
GO:0010259	multicellular organismal aging	biological_proccess	IEA
GO:0030850	prostate gland development	biological_proccess	IEA
GO:0030859	polarized epithelial cell differentiation	biological_proccess	IEA
GO:0035121	tail morphogenesis	biological_proccess	IEA
GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	biological_proccess	IEA
GO:0043589	skin morphogenesis	biological_proccess	IEA
GO:0043616	keratinocyte proliferation	biological_proccess	IEA
GO:0045617	negative regulation of keratinocyte differentiation	biological_proccess	IEA
GO:0048485	sympathetic nervous system development	biological_proccess	IEA
GO:0048646	anatomical structure formation involved in morphogenesis	biological_proccess	IEA
GO:0048807	female genitalia morphogenesis	biological_proccess	IEA
GO:0060157	urinary bladder development	biological_proccess	IEA
GO:0060197	cloacal septation	biological_proccess	IEA
GO:0030216	keratinocyte differentiation	biological_proccess	IEA
GO:0001738	morphogenesis of a polarized epithelium	biological_proccess	IEA
GO:0003690	double-stranded DNA binding	mollecular_function	IDA
GO:0003700	transcription factor activity	mollecular_function	IEA
GO:0008270	zinc ion binding	mollecular_function	IEA
GO:0019904	protein domain specific binding	mollecular_function	IPI
GO:0046872	metal ion binding	mollecular_function	IEA
GO:0003677	DNA binding	mollecular_function	IEA
GO:0042802	identical protein binding	mollecular_function	IEA
GO:0016563	transcription activator activity	mollecular_function	IEA
GO:0016564	transcription repressor activity	mollecular_function	IEA
GO:0043565	sequence-specific DNA binding	mollecular_function	IEA
GO:0003684	damaged DNA binding	mollecular_function	IEA
GO:0003682	chromatin binding	mollecular_function	IEA
GO:0005634	nucleus	cell_component	IEA
GO:0019718	rough microsome	cell_component	IDA
GO:0030425	dendrite	cell_component	IDA
GO:0043234	protein complex	cell_component	IDA
GO:0005737	cytoplasm	cell_component	IEA

Check GO Evidence Codes here

Information from other databases [+]

Gene related links:

Ensembl genome browser [?] : ENSRNOG00000001924
Expression info from Arrayexpress [?] : ENSRNOG00000001924
Protein expression from Protein Atlas: [?] ENSRNOG00000001924

Protein related links:

Uniprot protein info: Q9JJP6
PIR protein info: Q9JJP6
Protein interactions from IntAct: Q9JJP6

Other links

entrezgene: 246334
refseq_dna: NM_019221
refseq_peptide: NP_062094

Click on [?] for more information.