10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000068408 -------------------------------------ME----------------------------------------------------MLRRSSVFAAEVMEVFDRS---------- T_rubripes_ENSTRUP00000030263 -------------------------------------ME----------------------------------------------------MLRRSSVFAA---EVFDRS---------- G_aculeatus_ENSGACP00000006084 -------------------------------------MD----------------------------------------------------MLRRSSVFAA---EVFDRS---------- T_nigroviridis_ENSTNIP00000005841 -------------------------------------ME----------------------------------------------------MLRRSSMFAA---EVFDRS---------- A_carolinensis_ENSACAP00000000851 -------------------------------------MD----------------------------------------------------VLRRSSVFAAEVMEVFDRT---------- G_gallus_ENSGALP00000009257 -------------------------------------ME----------------------------------------------------VLRRSSVFAAEVMEVFDRS---------- T_guttata_ENSTGUP00000006267 -------------------------------------ME----------------------------------------------------VLRRSSVFAAEVMEVFDRS---------- O_latipes_ENSORLP00000002641 -------------------------------------LE----------------------------------------------------SMRACGVARVNPAQAFSRSA--------- O_anatinus_ENSOANP00000008963 -------------------------------------ME----------------------------------------------------VLRRSSVFAAEVMEVFDRS---------- M_domestica_ENSMODP00000020066 -------------------------------------ME----------------------------------------------------VLRRSSVFAAEVMEVFDRS---------- M_musculus_ENSMUSP00000027499 -------------------------------------ME----------------------------------------------------VLRRSSVFAAEIMDAFDRS---------- R_norvegicus_ENSRNOP00000024693 -------------------------------------ME----------------------------------------------------VLRRSSVFAAEIMDAFDRS---------- B_taurus_ENSBTAP00000011478 -------------------------------------ME----------------------------------------------------VLRRSSVFAAEIMDAFDRS---------- H_sapiens_ENSP00000314132 -------------------------------------ME----------------------------------------------------VLRRSSVFAAEIMDAFDRS---------- G_gorilla_ENSGGOP00000015296 -------------------------------------ME----------------------------------------------------VLRRSSVFAAEIMDAFDRS---------- M_mulatta_ENSMMUP00000007481 -------------------------------------ME----------------------------------------------------VLRRSSVFAAEIMDAFDRS---------- P_pygmaeus_ENSPPYP00000014939 -------------------------------------ME----------------------------------------------------VLRRSSVFAAEIMDAFDRS---------- T_rubripes_ENSTRUP00000018728 -------------------------------------ME----------------------------------------------------VLRRSSVFAAEVLDVFDRS---------- T_nigroviridis_ENSTNIP00000018321 -------------------------------------ME----------------------------------------------------VLRRSSVFAAEVLDVFDRS---------- G_aculeatus_ENSGACP00000018053 -------------------------------------ME----------------------------------------------------VLRRPSVMAAEVLDVFDRS---------- O_latipes_ENSORLP00000020538 -------------------------------------MD----------------------------------------------------VLRRSSVFAAEVLDVFERS---------- D_rerio_ENSDARP00000090569 -------------------------------------MN----------------------------------------------------VFARSSVLAAEMMDVFDRT---------- E_caballus_ENSECAP00000000132 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0087182 -------------------------------------MPGTSYPTNNDNFSNGFPMATTQSERL-LQAQNRRKFSFPATLHSASLLEVGGG--------PKET---TRRRLSNVSDAVTR D_melanogaster_FBpp0085443 -------------------------------------MAPTTSPPP-----KLAKFKSSSLDHEIYTANRRGTIATASSDWKALRGGVGGG-----AGGPGSVPNPSNGRSLHAGGPMTR A_aegypti_AAEL001521-PA -------------------------------------MLSAEAPVSHNH--------HLLPDRLSAPALARRKFSFPANLHSTVLHGDPPGSINSGSLQPSSTASFARRRLSNVSDVVTR A_aegypti_AAEL001515-PA -------------------------------------MEMTSP---------------------------------------------------------------------------TL A_gambiae_AGAP011552-PA -------------------------------------MSSTAG--------------AFHQQHQPQQQSPRSPIVAAAVAAAAAIGAVSGG----------------------------- C_intestinalis_ENSCINP00000019812 -------------------------------------MTSYTSDVNHNSIYETERKNKRTLLADNINS-----------------------IMRDSVTFVTSSIADLTSSCVSLGDDSVF C_intestinalis_ENSCINP00000016140 -------------------------------------MTSHESENASGFLKPEMESQRRHSWDGRFSTNKIDLGGESTVCRNDSKGRRRRELRRSHVVTEAPDVTLFEEQDQNNASTIPT D_rerio_ENSDARP00000089067 -------------------------------------MADGKNGETTD-ENELKGATGGED----------------------------------------------------------- D_rerio_ENSDARP00000095258 -------------------------------------MS--------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000052058 -------------------------------------MA--------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000017211 ------------------------------------------------------------D----------------------------------------------------------- T_rubripes_ENSTRUP00000032199 -------------------------------------MS--------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000018700 -------------------------------------MA-----------------------------SHPGGGDQG------------------------------------------- G_aculeatus_ENSGACP00000013488 -------------------------------------MA--------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000014135 -------------------------------------MS--------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000018978 -------------------------------------MADGGREKQDDGDREPRGAEGGED----------------------------------------------------------- T_nigroviridis_ENSTNIP00000007577 RSHPGAKSKGASTQR----------------------MS--------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000005643 -------------------------------------MS--------------------------------------------------------------------------------- O_latipes_ENSORLP00000021005 -------------------------------------MA--------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000011187 -------------------------------------MS--------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000040259 -------------------------------------MS--------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000002788 -------------------------------------MA--------------------------------------------------------------------------------- B_taurus_ENSBTAP00000017739 -------------------------------------MD--------------------------GSGEQP-RGGGP------------------------------------------- T_rubripes_ENSTRUP00000012873 QVG----------------------------------ME--------------------------------------------------------------------------------- O_anatinus_ENSOANP00000014671 AAPR---------------------------------MA--------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000010122 -------------------------------------MS--------------------------------------------------------------------------------- M_domestica_ENSMODP00000005598 -------------------------------------MA--------------------------------------------------------------------------------- D_rerio_ENSDARP00000096467 -------------------------------------MA--------------------------------------------------------------------------------- M_musculus_ENSMUSP00000086454 -------------------------------------MS--------------------------------------------------------------------------------- E_caballus_ENSECAP00000014770 -------------------------------------MS--------------------------------------------------------------------------------- G_gallus_ENSGALP00000010059 -------------------------------------MS--------------------------------------------------------------------------------- B_taurus_ENSBTAP00000008572 -------------------------------------MS--------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000010478 -------------------------------------MS--------------------------------------------------------------------------------- H_sapiens_ENSP00000365230 -------------------------------------MS--------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000012163 -------------------------------------MS--------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000022903 -------------------------------------MS--------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000007865 -------------------------------------MS--------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006866 -------------------------------------MY--------------------------------------------------------------------------------- H_sapiens_ENSP00000293288 -------------------------------------MD--------------------------GSGEQP-RGGGP------------------------------------------- G_aculeatus_ENSGACP00000017662 -------------------------------------MS--------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000050759 -------------------------------------MATHGAGGDYPGEDKEKNQGEGGAAGGPSLGAAGDRSGTG------------------------------------------- M_domestica_ENSMODP00000017160 -------------------------------------MD--------------------------GSGEQPRGGAGA------------------------------------------- M_musculus_ENSMUSP00000022806 -------------------------------------MA--------------------------------------------------------------------------------- M_domestica_ENSMODP00000024313 -------------------------------------MS--------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000017311 -------------------------------------MA--------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000002775 -------------------------------------MS--------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000005209 -------------------------------------MD--------------------------GSGEQP-RGGGP------------------------------------------- O_latipes_ENSORLP00000017513 QAHT---------------------------------MS--------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000001415 -------------------------------------MA--------------------------------------------------------------------------------- H_sapiens_ENSP00000250405 -------------------------------------MA--------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000019355 -------------------------------------MA--------------------------------------------------------------------------------- B_taurus_ENSBTAP00000026248 -------------------------------------MA--------------------------------------------------------------------------------- E_caballus_ENSECAP00000008404 -------------------------------------MA--------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000010457 -------------------------------------MA--------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005553 -------------------------------------MD--------------------------GSGEQS-RGGGP------------------------------------------- D_rerio_ENSDARP00000023687 -------------------------------------MA-----------------------------APSGGGDTG------------------------------------------- T_guttata_ENSTGUP00000002093 -------------------------------------MA--------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000016202 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000019323 -------------------------------------MD--------------------------GSGEQP-RGGGP------------------------------------------- G_gallus_ENSGALP00000020984 -------------------------------------MA--------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000031936 RKKGNNGVKDRDWEEQHATGNIIFRGSPDKYLTEQGWMA--------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000028328 -------------------------------------MD--------------------------GSGDHL-GGGGP------------------------------------------- M_domestica_ENSMODP00000024241 -------------------------------------MD--------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000036334 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000053903 -------------------------------------ME--------------------------------------------------------------------------------- M_musculus_ENSMUSP00000033093 -------------------------------------MD--------------------------GSGEQL-GSGGP------------------------------------------- 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000068408 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000030263 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000006084 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005841 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000000851 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000009257 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006267 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000002641 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008963 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000020066 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000027499 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000024693 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000011478 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000314132 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000015296 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000007481 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014939 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000018728 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000018321 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018053 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000020538 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000090569 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000000132 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0087182 K------LSYTIGWKAAQ------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085443 AASTSSLASSTRTMTNYQ------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001521-PA K------LSSTIGWKQPV------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001515-PA ANNFANVWTNRRSPIHHL------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011552-PA SAGGVVGWTNKRSPIHHL------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000019812 NS---------------------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000016140 KDDPTPVASENKNTNNRPWGLRRRITKTENHCEKIEDSTPANQTGTPKRRSGIASFATGSSPRNLWQPQKPSVRFTDVNDSNINAATPPDMSSRSFRNRRATVHYSSTGRPSVMERRHPA D_rerio_ENSDARP00000089067 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095258 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000052058 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000017211 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032199 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018700 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013488 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000014135 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018978 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007577 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005643 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000021005 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011187 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000040259 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000002788 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000017739 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000012873 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000014671 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010122 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005598 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000096467 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000086454 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000014770 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000010059 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008572 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010478 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000365230 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000012163 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022903 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000007865 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006866 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000293288 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000017662 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000050759 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000017160 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000022806 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024313 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017311 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002775 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000005209 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000017513 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000001415 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250405 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000019355 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000026248 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008404 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010457 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000005553 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023687 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000002093 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000016202 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000019323 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000020984 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031936 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000028328 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024241 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036334 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000053903 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033093 ------------------------------------------------------------------------------------------------------------------------ 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000068408 -----PTDKELVSQSKVLCRDYIHSRLHRAGIGWSKPEHG------------------------------------------------------SGGT--------LAEVSSVLLWLGDE T_rubripes_ENSTRUP00000030263 -----PTDKELVSQAKALCRDYIHSRLNRAGVGWSKADHGL---------------------------------------------------AASGGT--------LGEVSSVLMWLGAE G_aculeatus_ENSGACP00000006084 -----PTDKELVSQAKALCRDYIHSRLNRAGMGWSKPESGR---------------------------------------------------AAPGGG--------LGDVSSALLWLGDE T_nigroviridis_ENSTNIP00000005841 -----PTDKELVSQAKALCRDYIHSRLNRAGIGWSKAENGP---------------------------------------------------PASGGT--------LGEASAVLLWLGDE A_carolinensis_ENSACAP00000000851 -----PTDKELVSQAKVLCRDFIHSRLIRAGIGWNKPEHSV---------------------------------------------------PVPGGK--------LAEVSNILLRLGDE G_gallus_ENSGALP00000009257 -----PTDKELVSQAKALCRDYINSRLIRAGVSWSKPEHNT---------------------------------------------------PVPGGK--------LAEVSAILLCLGDE T_guttata_ENSTGUP00000006267 -----PTDKELVSQAKALCRDYINSRLIQAGVSWSKPEYNA---------------------------------------------------PVPGGK--------LAEVSTILLRLGDE O_latipes_ENSORLP00000002641 -----PTDKELVSQAKALCREYIHSRLNRAGIGWSKPEHAQ---------------------------------------------------AGAGGA--------LGEVSSVLLWLGEE O_anatinus_ENSOANP00000008963 -----PTDKELVSQAKALCREYIHSRLIRASLVWSKPDYNV---------------------------------------------------PSPGGK--------LAEVSTILLRLGDE M_domestica_ENSMODP00000020066 -----PTDKELVSQAKALGREYIHSRLIRAGLVWSKPEAKT---------------------------------------------------PTPGGK--------LAEVASILLRLGDE M_musculus_ENSMUSP00000027499 -----PTDKELVAQAKALGREYVHARLLRAGLSWSAPERAS---------------------------------------------------PAPGGR--------LAEVCTVLLRLGDE R_norvegicus_ENSRNOP00000024693 -----PTDKELVAQAKALGREYVHARLLRAGLSWSAPERAS---------------------------------------------------PAPGGR--------LAEVCTVLLRLGDE B_taurus_ENSBTAP00000011478 -----PTDKELVAQAKALGREFVHARLLRAGLSWSAPERAA---------------------------------------------------PVPGGR--------LAEVCAVLLRLADE H_sapiens_ENSP00000314132 -----PTDKELVAQAKALGREYVHARLLRAGLSWSAPERAA---------------------------------------------------PVP-GR--------LAEVCAVLLRLGDE G_gorilla_ENSGGOP00000015296 -----PTDKELVAQAKALGREYVHARLLRAGLSWSAPERAA---------------------------------------------------PVP-GR--------LAEVCAVLLRLGDE M_mulatta_ENSMMUP00000007481 -----PTDKELVAQAKALGREYVHARLLRAGLSWSAPERAA---------------------------------------------------PVP-GR--------LAEVCAVLLRLGDE P_pygmaeus_ENSPPYP00000014939 -----PTDKELVAQAKALGREYVHARLLRAGLSWSAPERAA---------------------------------------------------PVP-GR--------LAEVCAVLLRLGDE T_rubripes_ENSTRUP00000018728 -----LTEKELVSHSKALCRDYILSRLNQNGLGCSKAELNL---------------------------------------------------SPSSAA--------LADASMVLLCLGDE T_nigroviridis_ENSTNIP00000018321 -----LTEKELVSHSKALCRDYILSRLTQSGLGWSKSELNL---------------------------------------------------SPSSTA--------LADASMVLLCLGDE G_aculeatus_ENSGACP00000018053 -----LTEKELVSQSKALCRDYILSRLHQNGQGWSKTELHL---------------------------------------------------SPSSAA--------LAEVSLVLLCLGDE O_latipes_ENSORLP00000020538 -----LSEKELVTQSKALCRDYILSRLHQNGMGWSKAEINF---------------------------------------------------SPSNAA--------LSEVTMVLLCLGDE D_rerio_ENSDARP00000090569 -----HTEKELVFQSKELCRDFIHSRITREGLSWSKVELDL---------------------------------------------------PEPRGV--------LVDVSVVLLKLGDE E_caballus_ENSECAP00000000132 ----------------------------------------------------------------------------------------------------------------------DE D_melanogaster_FBpp0087182 -----IPAQDIISQGRCLCGHYIKRRLRRSGLFNKKLGLQRIRSILG---------------------------------------------STSMGI--------VRDVFPAVQVLGDE D_melanogaster_FBpp0085443 -----EYKMDIINQGKCLCGQYIRARLRRAGVLNRKV-TQRLRNILD---------------------------------------------PGSSHV--------VYEVFPALNSMGEE A_aegypti_AAEL001521-PA -----LPSQDIITQGKCLCGQYIRCRLKKSGVFNRKLGLQRIRSIVG---------------------------------------------TPTIHV--------VREVFPALLSVGEE A_aegypti_AAEL001515-PA -----TTTQDVINQGKCLCGEYIRARLRRSGLLNRKI-LQRLRSTME---------------------------------------------VPNCVV--------VRETSPILNGMGEE A_gambiae_AGAP011552-PA -----TTSQDVINQGKCLCGEYIRARLKRSGLLNRKI-LQRLRNSMEHCMAGSGG-------------------------------------LGGGAV--------VREALPILNGMGEE C_intestinalis_ENSCINP00000019812 -----TSYEEDVRLTTGICRDYICYRLKRDGFGERVTVT-----------------------------------------------------EHAPAH--------NHNLSNKILNLGSG C_intestinalis_ENSCINP00000016140 RIALEAKEGKALEQTKDICKDYIVHRLQQRKLANRVKVTRQ------------------------------------------------------QSA--------SRALSRDVIFIASE D_rerio_ENSDARP00000089067 -----VVDDAIIEQSAVLLRGYVIQQATIDDPNIHVSHETL----------------------------------------------GGRPQDEEDPQ--------IKEVVDQLLKIADD D_rerio_ENSDARP00000095258 ------------YYNRELVVFFIKYKLSQRNYPCNHIGL-TEDTNRTDGAEENG-EGAAGATTLVNGTMNRTNASSTGTPPQSPASSPQRQTNGSGGL---------DAVKEALRDSANE X_tropicalis_ENSXETP00000052058 -----HPRRGGY-DHRDIVVKYIHYKLSQKGYEWEEGRQQVSAEHPQASAAISNYSDDGEMPAASADSRG-----PPQSSLASAAASSDEETPTMQPV--------PPAVLQTLSRAGDE T_nigroviridis_ENSTNIP00000017211 -----VVDDPILEQGAVVLRGYVIERIHVEQPSLHVSSEDL----------------------------------------------GGRSEEQRDPQ--------TKEVVEQLLKIADD T_rubripes_ENSTRUP00000032199 ------------YNNRELVEHFLRYKLSQRNYPTSLLRP-EDTDGRTEGEKRSP-GASNGLLVRSRNR-------------------GGASPSAGAGI---------EAVNAALRDSAEE G_aculeatus_ENSGACP00000018700 -----NNKDQILELGTVLLKDFIFERVKRHGDSTETVTRTQ-----------------------------------------------LGGVELSDPN--------HKKLAMCLQQIGDE G_aculeatus_ENSGACP00000013488 ------------NINRELVEFFLSYKLSQKNHPTSLLRP-EDAGGRTEGDKANS-ASVPG------------RGSSAGQPGMSSP-----PPPPSGDT---------EAVKAALQDSANE T_rubripes_ENSTRUP00000014135 -------------QNRELVIFYIKYKLSQRNYPFNHNGLILEPPSRTDG---------QFVTTQFNGTF---NGASPGTPPATSL---------ATSL---------DTVKEALRDTGNE G_aculeatus_ENSGACP00000018978 -----VVDDPIMEQGAVVLRGYVVSRINAEDPSRHVSPEQL----------------------------------------------GGRPNEHQDPQ--------IKEVVKQLMKIADE T_nigroviridis_ENSTNIP00000007577 -------------LNRELVIFYIKYKLSQRNYPLSHI---VEPSSRTEG---------QFGTTQSNGTF---NGASPGTPPAPSQ-----HQQSLTSL---------DAVKEALRDTGNE G_aculeatus_ENSGACP00000005643 -------------QNRELVVFYINYKLSQRNLPLNHIGL-SEPPNRTGGGVEAGAAGGQRGATHSNGTF---NGTSPGTPPASPL--LQQRSPSTASL---------DAVKEALRDSANE O_latipes_ENSORLP00000021005 -----------NVSNRSIVEKYICHKLSKRGYVCGLNGGQRENAANNGSVGDHSP-------------------------------------TPADPL---------ADIHRVLREAGDE A_carolinensis_ENSACAP00000011187 ------------SSNRALVVDFLSYKLSQRGHSWHEIEM----ESGEEAME---------PANETGNTL---NGSPSWHPSPSHV--INGASEHPELLEEEEEENPRVDVSQTLREAGDE R_norvegicus_ENSRNOP00000040259 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD--VEENRTEAPEETE------PERETPSAI---NGNPSWHLADSPA--VNGATGHSSSL-DAREVIPMAAVKQALREAGDE T_nigroviridis_ENSTNIP00000002788 -----------REYNRDIVEKYIFHKLSKRGFVWRFEEVQDQNAANNGSVVAPAPTLVRRCHEAGTGP------------DRGSIPHLCKRTPQSEQH---------AAIHRVLREAGDE B_taurus_ENSBTAP00000017739 -----TSSEQIMKTGALLLQGFIQDRAGRMGGETPELGLEQ---------------------------------------------------VPQDAS--------TKKLSECLKRIGDE T_rubripes_ENSTRUP00000012873 -----------RECNRDIVENYICHKLSKRGFAWSFEDVQDENAANNGSVVAPAPTLVRRCHEAGTGPDR----------DRGSISHPCKEPPASDQH---------AAIHRVLREAGDE O_anatinus_ENSOANP00000014671 -----TPAPASVSDTRALVADFVGYKLRQKGF--------------------------------------------------------------------------AQPLHRAMRAAGDE T_nigroviridis_ENSTNIP00000010122 ------------YDNRELVEYFLGYKLAQRNYPSSLLRP-QEPDGWTEGDKKSP-AAVNGLLIRNRSR-------------------SGASASTGAGV---------EAVHAALRDSAEE M_domestica_ENSMODP00000005598 -----T--PASAPDTRALVADFVGYKLRQKGYACGTG-------------------------------------------------------PGEGPT--------TEPLHRAMRAAGDE D_rerio_ENSDARP00000096467 --------NEISYDNRNIVEKYLKHKLSKRGYVWKCQSSAEEDDTFNKAVEESSPNSDRRLQAPSAGG-------------GNNSECLIARVTRSDPH---------LRLYRVLRDAGDE M_musculus_ENSMUSP00000086454 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD--VEENRTEAPEETE------AERETPSAI---NGNPSWHLADSPA--VNGATGHSSSL-DAREVIPMAAVKQALREAGDE E_caballus_ENSECAP00000014770 ------------QSNRELVVDFLSYKLSQKGYNWSQFSD--VEENRTEAPEGTE------SEMETPSAI---NGNPSWHLADSPT--GNGATGHSSSL-DAREVIPMAAVKQALREAGDE G_gallus_ENSGALP00000010059 ------------SSNRELVIDFVSYKLSQRGHCWSELEE--EDENRTDTA----------AEAEMDSVL---NGSPSWHPPAGHV--VNGATVHRSSL-EVHEIVRASDVRQALRDAGDE B_taurus_ENSBTAP00000008572 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD--VEENRTEAPEGTE------SDMETPSAI---NGNASWHLADSPA--VNGATGHSRSS-DAREVIPMAAVKQALREAGDE C_familiaris_ENSCAFP00000010478 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD--VEENRTEAPEGTE------SEMETPSAI---NGNPSWHLADSPA--VNGATGHSSSL-DAREVIPMAAVKQALREAGDE H_sapiens_ENSP00000365230 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD--VEENRTEAPEGTE------SEMETPSAI---NGNPSWHLADSPA--VNGATGHSSSL-DAREVIPMAAVKQALREAGDE P_pygmaeus_ENSPPYP00000012163 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD--VEENRTEAPEGTE------SEMETPSAI---NGNPSWHLADSPA--VNGATGHSSSL-DAREVIPMAAVKQALREAGDE P_troglodytes_ENSPTRP00000022903 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD--VEENRTEAPEGTE------SEMETPSAI---NGNPSWHLADSPA--VNGATGHSSSL-DAREVIPMAAVKQALREAGDE M_mulatta_ENSMMUP00000007865 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD--VEENRTEAPEGTE------SEMETPSAI---NGNPSWHLVDSPA--VNGATGHSSSL-DAREVIPMAAVKQALREAGDE T_guttata_ENSTGUP00000006866 ------------SSNRELVIDFVSYKLSQKGYSWSQLEE--EDENRTDFAG---------EEDEMDGVL---NGSPSWHAATSHI--VNGATVHQNSL-EVHEIRRAADVRQALREAGDE H_sapiens_ENSP00000293288 -----TSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDP---------------------------------------------------VPQDAS--------TKKLSECLKRIGDE G_aculeatus_ENSGACP00000017662 -----------NECNRHIVEKYICHKLSKRGYAFGFDDVGEEDAASNGSMVVPPPTAVRRCREAGP--------------DGESFPRLCKRLPQSDPT--------AAATHRVLREAGDE X_tropicalis_ENSXETP00000050759 -----VSTEQILETGELLLNGFISDRLQNNPDVAGARALFP------------------------------------------------GSTQHSDPS--------IKRLSECLRKIGDE M_domestica_ENSMODP00000017160 -----TSSEQIMRTGAVLLQGFIQDRAGRVAGGAPELLLDS---------------------------------------------MGDSAPLPSDPR--------TKRLTECLRRIGDE M_musculus_ENSMUSP00000022806 -----T--PASTPDTRALVADFVGYKLRQKGYVCGAG-------------------------------------------------------PGEGPA--------ADPLHQAMRAAGDE M_domestica_ENSMODP00000024313 ------------HSNRELVIDFLSYKLSQKGYNWSQFED----ENRTEVLEGA----------EIPSTV---NGSPSWHPADSRA--VSGATGHSSSL-DAHETIPVAAVKQALREAGDE A_carolinensis_ENSACAP00000017311 -----HPGIRGY-DNREIVLRYIHYKLSQKGYDWVASGDRGNL------AAAAAAAAA--TPSAPTVSAS-----LSPELLNSDPVSTNAPREEPDPV--------PQVVHTTLRQAGDE O_cuniculus_ENSOCUP00000002775 ------------QSNRELVVDFLSYKLSQKGYSWSQFSD--VEENRTEAPEGTG------PEMETPSAI---NGNPAWHPADSPA--VNGATGHSSSL-DAREVIPMTAVKQALREAGDE M_mulatta_ENSMMUP00000005209 -----TSSEQIMKTGALLLQGFIQDRAGRMGGETPELALDP---------------------------------------------------VPQDAS--------TKRLSECLKRIGDE O_latipes_ENSORLP00000017513 ------------HCNRELVRFYLAYKMSCRDYPVSLLKP-TDDGGETEEDHSD--ARNRRLVSSEDGR-------------------LRRSCPCCASM---------DAIKSTLKDSADE G_gorilla_ENSGGOP00000001415 -----T--PASAPDTRALVADFVGYKLRQKGYVCGAG-------------------------------------------------------PGEGPA--------ADPLHQAMRAAGDE H_sapiens_ENSP00000250405 -----T--PASAPDTRALVADFVGYKLRQKGYVCGAG-------------------------------------------------------PGEGPA--------ADPLHQAMRAAGDE M_mulatta_ENSMMUP00000019355 -----T--PASAPDTRALVADFVGYKLRQKGYVCGAG-------------------------------------------------------PGEGPA--------ADPLHQAMRAAGDE B_taurus_ENSBTAP00000026248 -----T--PASAPDTRALVADFVGYKLRQKGYVCGAG-------------------------------------------------------PGEGPA--------ADPLHQAMRAAGDE E_caballus_ENSECAP00000008404 -----T--PASAPDTRALVADFVGYKLRQKGYVCGAG-------------------------------------------------------PGEGPA--------ADPLHQAMRAAGDE P_troglodytes_ENSPTRP00000010457 -----T--PASAPDTRALVADFVGYKLRQKGYVCGAG-------------------------------------------------------PGEGPA--------ADPLHQAMRAAGDE O_cuniculus_ENSOCUP00000005553 -----TSSEQIMKTGALLLQGFIQDRASRMGGQTPELAVAQ---------------------------------------------------GPQDES--------TKKLSECLKRIGDE D_rerio_ENSDARP00000023687 -----SGNDQILDLGAALLNNFVYERVRRHGDRDAEVTRSQ-----------------------------------------------LGGVELCDPS--------HKRLAQCLQQIGDE T_guttata_ENSTGUP00000002093 -----HPGRRGY-DNREIVLKYIHYKLSQRGYDWAAGEDRASLPPDHSASAAAAIAAA--AIAAAGTSDHTGLVSPHPEPPGSATASHTPPAEGLRPA--------PQAVHLVLRQAGDE A_carolinensis_ENSACAP00000016202 ------AEDQVAQETEEVFQSYAFYRYQQEREQTEGDVPHDPEIAAIP--------------------------------------------HEPNST--------NCQVGRRLATIGDD P_troglodytes_ENSPTRP00000019323 -----TSSEQIMKTGALLLQGFIQDRAGRMRGEAPELALDP---------------------------------------------------VPQDAS--------TKKLSECLKRIGDE G_gallus_ENSGALP00000020984 -----HPGRRGY-DNREIVLKYIHYKLSQRGYDWAAGEDRPPVPP----APAPAAAPA--AVAAAGASSH-----HRPEPPGSAAASEVPPAEGLRPA--------PPGVHLALRQAGDE X_tropicalis_ENSXETP00000031936 -----Q----SELGSRALVEDFVRYKLCQRSLVPEPA----------------------------------------------------------GAA--------SCSLHSAMRAAGDE R_norvegicus_ENSRNOP00000028328 -----TSSEQIMKTGAFLLQGFIQDRAERMAGETPELTLEQ---------------------------------------------------PPQDAS--------TKKLSECLRRIGDE M_domestica_ENSMODP00000024241 --------DYEFHYVHMLARDYLKHVQQT---------------------------------------------------------------PPLGSC--------LNKTSQILQKVAFS T_rubripes_ENSTRUP00000036334 ----------------------------------------------------------------------------------------------SDPN--------HKKLAQCLQKIGDE X_tropicalis_ENSXETP00000053903 ------------GSSRDLVEKFVCKKLSQKGACGEFSSNSQPKGVSNGSSEGPG--------------------------------------ATQGIV--------GEEVLQALLDASEE M_musculus_ENSMUSP00000033093 -----TSSEQIMKTGAFLLQGFIQDRAGRMAGETPELTLEQ---------------------------------------------------PPQDAS--------TKKLSECLRRIGDE 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000068408 LEYLRPNVYRNVARQLNIT----IASENIVSDAFLAVAAEIFST--------------------EYSRKGLEKHKG-VTWGKIVSLYAVAGALAVDCVRH-GHPAMV---HTIVDCMGEF T_rubripes_ENSTRUP00000030263 LEYLRPNVYCNVARQLNIT----VASESIMSDAFLAVAADIFST--------------------EYILR--QRYEG-VTWGKVVSLYAVAGALAVDCVRH-GHPAMI---HTIVDCMGEF G_aculeatus_ENSGACP00000006084 LEYLRPNVYRNVARQLNIT----VASESIVSDAFLAVAADIFST-------------------------------G-VTWGKVVSLYAVAGALAVDCVRH-GHPAIV---HTIVDCMGEF T_nigroviridis_ENSTNIP00000005841 LEHLRPNVYCNVARQLNIT----VASESIMSDAFLAVAADIFST-------------------------------G-VTWGKVVSLYAVAGALAVDCVRH-GHPAMV---HTIVDCMGEF A_carolinensis_ENSACAP00000000851 LEYIRPNLYRNVARQLNIS----LHSETVVTDAFLAVATQIFSS-------------------------------G-ITWGKIVSLYAVAAGLAVDCVRH-AQPAMV---HTIVDCLGEF G_gallus_ENSGALP00000009257 LEYIRPNVYRNIARQLNIS----LHSETVVTDAFLAVAAQIFTA-------------------------------G-ITWGKVVSLYAVAAGLAVDCVRH-AQPAMV---HTIVDCLGEF T_guttata_ENSTGUP00000006267 LEYIRPNVYRNIARQLNIS----LHSETVVSDAFLAVATQIFSA-------------------------------G-ITWGKVVSLYAVAAGLAVDCVRH-AQPAMV---HTIVDCLGEF O_latipes_ENSORLP00000002641 LEYLRPNVYRNVARQLNIT----VASESIVSDAFLAVAADIFST-------------------GRISEKQNHCHKR-ITWGKVVSLYAVAGALAVDCVRH-GHPAMV---HTIVDCMGEF O_anatinus_ENSOANP00000008963 LEYIRPNVYRNIARQLNIS----LHSETVVTDAFLAVATQIFSA-------------------------------G-ITWGKVVSLYAVAAGLAVDCVKQ-GQPAMV---HTIVDCLGEF M_domestica_ENSMODP00000020066 LEYIRPNVYRNIARQLNIS----LQSESVVTDAFLAVATQIFAA-------------------------------G-ITWGKVVSLYAVAAGLAVDCVKQ-AQPAMV---HTIVDCLGEF M_musculus_ENSMUSP00000027499 LEQIRPSVYRNVARQLHIP----LQSEPVVTDAFLAVAGHIFSA-------------------------------G-ITWGKVVSLYSVAAGLAVDCVRQ-AQPAMV---HALVDCLGEF R_norvegicus_ENSRNOP00000024693 LEQIRPSVYRNVARQLHIP----LQSEPVVTDAFLAVAGHIFSA-------------------------------G-ITWGKVVSLYSVAAGLAVDCVRQ-AQPAMV---HALVDCLGEF B_taurus_ENSBTAP00000011478 LELIRPSVYRNVARQLNLS----LQSETVVTDAFLAVATQIFSA-------------------------------G-ITWGKVVSLYSVAAGLAVDCVRQ-AQPALV---HALVDCLGEF H_sapiens_ENSP00000314132 LEMIRPSVYRNVARQLHIS----LQSEPVVTDAFLAVAGHIFSA-------------------------------G-ITWGKVVSLYAVAAGLAVDCVRQ-AQPAMV---HALVDCLGEF G_gorilla_ENSGGOP00000015296 LEMIRPSVYRNVARQLHIS----LQSEPVVTDAFLAVAGHIFSA-------------------------------G-ITWGKVVSLYAVAAGLAVDCVRQ-AQPAMV---HALVDCLGEF M_mulatta_ENSMMUP00000007481 LEMIRPSVYRNVARQLHIS----LQSEPVVTDAFLAVAGHIFSA-------------------------------G-ITWGKVVSLYAVAAGLAVDCVRQ-AQPAMV---HALVDCLGEF P_pygmaeus_ENSPPYP00000014939 LEMIRPSVYRNVARQLHIS----LQSEPVVTDAFLAVAGHIFSA-------------------------------G-ITWGKVVSLYAVAAGLAVDCVRQ-AQPAMV---HALVDCLGEF T_rubripes_ENSTRUP00000018728 LESMQPSLYRNVARQLNIS----VAMENMVSDAFIGVATEILST--------------------GTNQRFLTKIQG-ITWGKVVSMYAVAGALAVDCVRQ-GHATTV---HILVDSLGQF T_nigroviridis_ENSTNIP00000018321 LESMQPSLYRNVARQLNIS----VAMENMVSDAFIAVATEILST-------------------------------G-ITWGKVVSMYAVAGALAVDCVRQ-GHPTTV---HILVDSLGQF G_aculeatus_ENSGACP00000018053 LESIRPSLYRNVARQLNIS----VAMENMVSDAFIGVATEIFST-------------------------------G-ITWGKVVSMYAVAGALAVDCVRQ-GHPATV---HILVASLGQF O_latipes_ENSORLP00000020538 LECIQPGLYRNVARQLNIS----VAMENVVSDAFLGVATEIFSA--------------------VFSAKTQQTDSI-ITWGKVVSMYAVAGALAVDCVRQ-GYLTTV---HILVDSLGQF D_rerio_ENSDARP00000090569 LECMRPYVYRNIAKQLNIS----VSVEAVVSDAFLSVATEVIAM--------------------DYATNTVFDFKG-ITWGKVVAIYAVAAGLAVDCVRL-GHPVMV---HTIVDSLGEF E_caballus_ENSECAP00000000132 LELIRPSVYRNVARQLNIS----LQSETVVTDAFLAVSAQIF-A-------------------------------G-ITWGKVVSLYLVAAGLAVDCVRQ-AQPAMV---HALVDCLGEF D_melanogaster_FBpp0087182 LERMHPRIYNGVARQICRNPGGEFHTPDAVSLLLGAVGRELFRV-------------------------------E-ITWSKVISLFAIAGGLSVDCVRQ-GHPEYL---PKLMESVSEV D_melanogaster_FBpp0085443 LERMHPRVYTNISRQLSRAPFGELEDSDMAPMLLNLVAKDLFRS-------------------------------S-ITWGKIISIFAVCGGFAIDCVRQ-GHFDYL---QCLIDGLAEI A_aegypti_AAEL001521-PA LERMYPRVYNGVARQLSRIGRGELKTPETAPVLLSAIARDLFRS-------------------------------D-ITWGKVVSLFAIAGGLSVDCVRQ-GHPDYL---PKLIEGVADV A_aegypti_AAEL001515-PA LERMHPRLYTNVSRQISVEPWGELTEPDSVCYLLHIVAKDLFKT-------------------------------D-ITWGKVISLFAIAGGLAVDCVRQ-EHYDYL---QQLIEGTTDV A_gambiae_AGAP011552-PA LERMHPRLYSNVSRQISNEPWGELTEPDTVGYLLHVVAKDLFKS-------------------------------G-ITWGKVISLFAIAGGLAVDCVRQ-DHADYL---QQLIEGTADV C_intestinalis_ENSCINP00000019812 FERMFPKSFRQISRQIGYV----FSSEATVRRLYFRMGVHIMGV----------------------------VECN-YTWGRILSLLGLAGAMAVDCISQ-GHPELA---ESMIGISSDF C_intestinalis_ENSCINP00000016140 LERMQKHLYSDVSKQIGIT----LRSEDVLRKVFFELAGEILTTEPVTIPKEATVNGETKKEKSRAFVSSGSRIIE-ITWGRICAVVAIAGGLSIDCVNQ-GHSDLV---NQLIEFCGEF D_rerio_ENSDARP00000089067 LN-------KNAELQHLIS----TVQSNCAQDVFMTVARSIFDD-------------------------------G-INWGRVVALFHLAYRLIFQALTQ-NHLEII---KNIISWFLQF D_rerio_ENSDARP00000095258 FELRYSRAFNDLSSQLHIT-------PATAYQSFESVMDEVFRD-------------------------------G-VNWGRIVGLFAFGGALCVECVEK-EMSPLV---GRIAEWMTVY X_tropicalis_ENSXETP00000052058 FSRLYQQDFRQISGLLHLT-------PSTVRVRFATVVEELFHD-------------------------------G-VNWGRIVAFFEFGGVMCVESVNR-EMSPLV---DSIVGWMTEY T_nigroviridis_ENSTNIP00000017211 LN-------RNAEFQHLVS----QVQGNCAQDVFMQVARSIFAD-------------------------------G-INWGRVVALFHLAYRLILKALTT-NHLENI---RTVIGWVLQV T_rubripes_ENSTRUP00000032199 FEKLFAQAFSDLSSQLDIT-------PDTAYQSFKNVMDEVFKD-------------------------------G-VNWGRVVGLFAFGGVLCVECVEK-DASQLV---CRIADWMTIY G_aculeatus_ENSGACP00000018700 LD-------GNVELQRMMN----DSSLGPTKDVFLKVAFEIFSD-------------------------------GKFNWGRVVALFYFACRLVIKALVT-KVPDII---RTIISWTMDY G_aculeatus_ENSGACP00000013488 FELLFTQAFSDLSLQLDVT-------PDTAYHSFKSVMDEVFKD-------------------------------G-VNWGRVVGLFAFGGVLCVECVEK-DMTELV---SRIADWMTTY T_rubripes_ENSTRUP00000014135 FELRYTCAFSDLHNQLHIT-------PATAYQSFENVMDEVFRD-------------------------------G-VNWGRIVGLFAFGGALCVECVEK-EMSPLV---GRIIEWMTVY G_aculeatus_ENSGACP00000018978 MN-------RNAELQRLIS----QVPGNCAQDIFMKVAKSIFDD-------------------------------G-INWGRVVALFHLAYRLIYRALTT-NHLENI---RIIIGWVLRF T_nigroviridis_ENSTNIP00000007577 FELRYTCAFSDLHNQLHIT-------PATAYQSFENVMDEVFRD-------------------------------G-VNWGRIVGLFAFGGALCVECVEK-EMNPLV---GRIIEWMTVY G_aculeatus_ENSGACP00000005643 FELRYARAFSDLHNQLHIT-------PATAYQSFEDVMDEVFRD-------------------------------G-VNWGRIVGLFAFGGALCVECVDK-EMSPLV---GRIVEWMTLY O_latipes_ENSORLP00000021005 LERLYQRDFTEMSRQLYLT-------STTAKTRFAEVIDELFRD-------------------------------G-VNWGRIIAFFEFGGTVCVECASNEEMSTQV---ASIAEWMTEY A_carolinensis_ENSACAP00000011187 FELRYRRAFSDLTSQLHIT-------LGTAYQSFEQVVNELFHD-------------------------------G-VNWGRIVAFFSFGGALCVESVDK-EMQGLV---VRIASWMTTY R_norvegicus_ENSRNOP00000040259 FELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVVNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESVDK-EMQVLV---SRIASWMATY T_nigroviridis_ENSTNIP00000002788 LERLYQPDFTEMSRQLYLT-------STTAQRRFAEVIDELFRD-------------------------------G-VNWGRIIAFFEFGAAVCAECAAKEEMSPQV---DNIAEWMTEY B_taurus_ENSBTAP00000017739 LD-------SNMELQRMIA----AVDTDSPREVFFRVAAEMFSD-------------------------------GNFNWGRVVALFYFASKLVLKALCT-KVPELI---RTIMGWTLDF T_rubripes_ENSTRUP00000012873 LERLYQPDFTEMSRQLYLS-------STTAQRRFAEVIDELFRD-------------------------------G-VNWGRIIAFFEFGGAVCAECAAKEEMSPQV---DNIAEWMTEY O_anatinus_ENSOANP00000014671 FESRFRRAFSDLASQLHVT-------PGSAQQRFTQVSDELFQG-------------------------------G-PNWGRLVAFFVFGAALCAESVNK-EMEPLV---GQVQDWMVAY T_nigroviridis_ENSTNIP00000010122 FEKLFAQAFSDLSSQLVIT-------PDTAYQSFKNVMDEVFKD-------------------------------G-VNWGRIVGLFAFGGVLCVECVEK-DASELV---CRIADWMTIY M_domestica_ENSMODP00000005598 FESRFRRTFSDLAAQLHVT-------PGSAQQRFTQVSDELFQG-------------------------------G-PNWGRLVAFFVFGAALCAESVNK-EMEPLV---GQVQDWMVTY D_rerio_ENSDARP00000096467 IERIYQREFEEMSQQMVFN-------PNSAQRSFLTVAEELFRD-------------------------------G-VNWGRIIAFFEFGGTMCVESVNR-EMASQV---DNIAHWMTDY M_musculus_ENSMUSP00000086454 FELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVVNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESVDK-EMQVLV---SRIASWMATY E_caballus_ENSECAP00000014770 FELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVVNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESVDK-EMQVLV---SRIATWMATY G_gallus_ENSGALP00000010059 FELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVVNELFHD-------------------------------G-VNWGRIVAFFSFGGALCVESVDK-EMRVLV---GRIVSWMTTY B_taurus_ENSBTAP00000008572 FELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVVNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESVDK-EMQVLV---SRIATWMATY C_familiaris_ENSCAFP00000010478 FELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVVNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESVDK-EMQVLV---SRIAAWMATY H_sapiens_ENSP00000365230 FELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVVNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESVDK-EMQVLV---SRIAAWMATY P_pygmaeus_ENSPPYP00000012163 FELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVVNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESVDK-EMQVLV---SRIAAWMATY P_troglodytes_ENSPTRP00000022903 FELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVVNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESVDK-EMQVLV---SRIAAWMATY M_mulatta_ENSMMUP00000007865 FELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVVNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESVDK-EMQVLV---SRIAAWMATY T_guttata_ENSTGUP00000006866 FELRYRRAFSDLTSQLHIT-------PSTAYQSFEQVVNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESVVK-EMRVLV---KRIVSWMTTY H_sapiens_ENSP00000293288 LD-------SNMELQRMIA----AVDTDSPREVFFRVAADMFSD-------------------------------GNFNWGRVVALFYFASKLVLKALCT-KVPELI---RTIMGWTLDF G_aculeatus_ENSGACP00000017662 LERLYQPDFTEMSRQLYLT-------STTAQRRFAEVIDELFRD-------------------------------G-VNWGRIIAFFEFGGTVCAECVAKEEMASQV---DNIAEWMTEY X_tropicalis_ENSXETP00000050759 LD-------ANIELQRRIE----CVPCNSPKQVFFHVAKELFAD-------------------------------GVFNWGRVVALFYFACKLVVKALCT-KVPEMI---RTIINWTMEY M_domestica_ENSMODP00000017160 LD-------SNMELQRMIA----AVETDSPREVFFRVAAEMFSD-------------------------------GNFNWGRVVALFYFASKLVLKALCT-KVPELI---RTIVGWTLDF M_musculus_ENSMUSP00000022806 FETRFRRTFSDLAAQLHVT-------PGSAQQRFTQVSDELFQG-------------------------------G-PNWGRLVAFFVFGAALCAESVNK-EMEPLV---GQVQDWMVAY M_domestica_ENSMODP00000024313 FELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVVNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESVDK-EMEVLV---GRITSWMATY A_carolinensis_ENSACAP00000017311 FSRRYRRDFAQMSGQLHLT-------PSTARSRFVAVVEELFQD-------------------------------G-VNWGRIVAFFEFGGMLCVESVSR-EMSPLV---DNIATWMTEY O_cuniculus_ENSOCUP00000002775 FELRYRRAFSDLTSQLHIT-------PGTAYQSFEQVVNELFRD-------------------------------G-VNWGRIVAFFSFGGALCVESVDK-EMEVLV---SRIAAWMATY M_mulatta_ENSMMUP00000005209 LD-------SNMELQRMIA----AVDTDSPREVFFRVAADMFSD-------------------------------GNFNWGRVVALFYFASKLVLKALCT-KVPELI---RTIMGWTLDF O_latipes_ENSORLP00000017513 FERRFHQGFSDLSVQLHIT-------PDTAYQNFKRVLDELFKD-------------------------------G-INWGRVVGLFVFGGALCVECVER-NMGELV---SRIAEWMTQY G_gorilla_ENSGGOP00000001415 FETRFRRTFSDLAAQLHVT-------PGSAQQRFTQVSDELFQG-------------------------------G-PNWGRLVAFFVFGAALCAESVNK-EMEPLV---GQVQEWMVAY H_sapiens_ENSP00000250405 FETRFRRTFSDLAAQLHVT-------PGSAQQRFTQVSDELFQG-------------------------------G-PNWGRLVAFFVFGAALCAESVNK-EMEPLV---GQVQEWMVAY M_mulatta_ENSMMUP00000019355 FETRFRRTFSDLAAQLHVT-------PGSAQQRFTQVSDELFQG-------------------------------G-PNWGRLVAFFVFGAALCAESVNK-EMEPLV---GQVQEWMVAY B_taurus_ENSBTAP00000026248 FETRFRRTFSDLAAQLHVT-------PGSAQQRFTQVSDELFQG-------------------------------G-PNWGRLVAFFVFGAALCAESVNK-EMEPLV---GQVQEWMVAY E_caballus_ENSECAP00000008404 FETRFRRTFSDLAAQLHVT-------PGSAQQRFTQVSDELFQG-------------------------------G-PNWGRLVAFFVFGAALCAESVNK-EMEPLV---GQVQEWMVAY P_troglodytes_ENSPTRP00000010457 FETRFRRTFSDLAAQLHVT-------PGSAQQRFTQVSDELFQG-------------------------------G-PNWGRLVAFFVFGAALCAESVNK-EMEPLV---GQVQEWMVAY O_cuniculus_ENSOCUP00000005553 LD-------SNMELQRMIA----AVDTDSPREVFFRVAADMFAD-------------------------------GNFNWGRVVALFYFATKLVLKALCT-KVPELI---RTIMGWTLDF D_rerio_ENSDARP00000023687 LD-------GNAQLQSMLN----NSNLQPTQDVFIRVAREIFSD-------------------------------GKFNWGRVVALFYFACRLVIKAIST-RVPDII---RTIISWTMSY T_guttata_ENSTGUP00000002093 FSRRYQRDFSQMSGQLHLT-------PFTARSRFVAVVEELFRD-------------------------------G-VNWGRIVAFFEFGGVMCVESVNR-EMFPLV---DNIATWMTEY A_carolinensis_ENSACAP00000016202 INARYDKEFSEMLKSLQPT-------KDNAYEYFIRIASSLFES-------------------------------G-INWGRVIALLGFGYRMAIHVYQH-GMTGFL---RRIARYMADF P_troglodytes_ENSPTRP00000019323 LD-------SNMELQRMIA----AVDTDSPREVFFRVAADMFSD-------------------------------GNFNWGRVVALFYFASKLVLKALCT-KVPELI---RTIMGWTLDF G_gallus_ENSGALP00000020984 FSRRYQRDFAQMSGQLHLT-------PFTAHGRFVAVVEELFRD-------------------------------G-VNWGRIVAFFEFGGVMCVESVNR-EMSPLV---DNIATWMTEY X_tropicalis_ENSXETP00000031936 FEERFRQAFSEISTQIHVT-------PGTAYARFAEVAGSLFQG-------------------------------G-VNWGRIVAFFVFGAALCAESVNK-EMSPLL---PRIQDWMVTY R_norvegicus_ENSRNOP00000028328 LD-------NNMELQRMIA----DVDTDSPREVFFRVAADMFAD-------------------------------GNFNWGRVVALFYFASKLVLKALCT-KVPELI---RTIMGWTLDF M_domestica_ENSMODP00000024241 VQQEVEKDMETCLSTLDIV------SVESARRIFNSVMKKEFED-------------------------------GVINWGRIVTIFAFGGILIKKLLRH-RAPLTMGTQEEISHFIAEF T_rubripes_ENSTRUP00000036334 LD-------GNMELQRMIN----DSALKPTKDMFMKVALEIFSD-------------------------------GKFNWGRVVALFYFACRLVIKALVT-HVPDII---RTIISWTMDY X_tropicalis_ENSXETP00000053903 FELRYQRAFSDLTAQLHLT-------QDTAQQSFQQVVGELFRD-------------------------------G-TNWGRIVAFFSFGRALCVESANK-EMTELL---PRIVQWMVQY M_musculus_ENSMUSP00000033093 LD-------SNMELQRMIA----DVDTDSPREVFFRVAADMFAD-------------------------------GNFNWGRVVALFYFASKLVLKALCT-KVPELI---RTIMGWTLDF 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000068408 V-RKSLASWLKKRGGWA-DITK----------------------------CVVSTDP---SFHSHW-------------------------------------------------LVTAA T_rubripes_ENSTRUP00000030263 V-RKSLISWLKRRGGWV-DVTK----------------------------CVVNTDP---NFHSHW-------------------------------------------------LMSAL G_aculeatus_ENSGACP00000006084 V-RKSLTTWLKRRGGWV-DVTK----------------------------CVVNTDP---SFRSHW-------------------------------------------------LVSAV T_nigroviridis_ENSTNIP00000005841 V-RKSLTSWLKRRGGWV-DVTR----------------------------CVVNTNP---NFDSHW-------------------------------------------------LVSAL A_carolinensis_ENSACAP00000000851 V-RKTLVTWMKRRGGWS-DITK----------------------------CVVNTDP---NLRSHW-------------------------------------------------LVAAI G_gallus_ENSGALP00000009257 V-RKTLVTWLKRRGGWA-DITK----------------------------CVVSTDP---SLRSHW-------------------------------------------------LVAAV T_guttata_ENSTGUP00000006267 V-RKTLVTWLKRRGGWA-DITK----------------------------CVVNTDP---NLRSHW-------------------------------------------------LVAAV O_latipes_ENSORLP00000002641 A-RKSLTVWLKKRGGWV-DMTK----------------------------CVVNTDP---SFHSHW-------------------------------------------------LLAAV O_anatinus_ENSOANP00000008963 V-RKTLVTWLKRRGGWA-DIMK----------------------------CVVNTDP---SLRSHW-------------------------------------------------LVAAV M_domestica_ENSMODP00000020066 V-RKTLVTWLKRRGGWA-DIMK----------------------------CVVDSDP---SLRSHW-------------------------------------------------LVAAL M_musculus_ENSMUSP00000027499 V-RKTLATWLRRRGGWT-DVLK----------------------------CVVSTDP---GFRSHW-------------------------------------------------LVATL R_norvegicus_ENSRNOP00000024693 V-RKTLATWLRRRGGWT-DVLK----------------------------CVVSTDP---GFRSHW-------------------------------------------------LVATL B_taurus_ENSBTAP00000011478 V-RKTLATWLRRRGGWT-DVLK----------------------------CVVSTDP---GLRSHW-------------------------------------------------LVAAL H_sapiens_ENSP00000314132 V-RKTLATWLRRRGGWT-DVLK----------------------------CVVSTDP---GLRSHW-------------------------------------------------LVAAL G_gorilla_ENSGGOP00000015296 V-RKTLATWLRRRGGWT-DVLK----------------------------CVVSTDP---GLRSHW-------------------------------------------------LVAAL M_mulatta_ENSMMUP00000007481 V-RKTLATWLRRRGGWT-DVLK----------------------------CVVSTDP---GLRSHW-------------------------------------------------LVAAL P_pygmaeus_ENSPPYP00000014939 V-RKTLATWLRRRGGWT-DVLK----------------------------CVVSTDP---GLRSHW-------------------------------------------------LVAAL T_rubripes_ENSTRUP00000018728 V-RKFLVPWLKRRGGWA-DISR----------------------------CVVKKDL---APEHHW-------------------------------------------------LSSSV T_nigroviridis_ENSTNIP00000018321 V-RRFLVPWLKRRGGWA-DITR----------------------------CVVRKDL---APEHHW-------------------------------------------------LFSSV G_aculeatus_ENSGACP00000018053 V-RKFLVPWLKRRGGWA-EMCK----------------------------CVLKKDL---PPEHHW-------------------------------------------------LSSAM O_latipes_ENSORLP00000020538 V-RKFLVHWLKRRGGWA-EITK----------------------------CVVKKEL---TSEQPW-------------------------------------------------LSSIM D_rerio_ENSDARP00000090569 V-RRSLVPWLKKRGGWV-DILK----------------------------CVVNMDS---RAHVHW-------------------------------------------------LSTAV E_caballus_ENSECAP00000000132 V-RKTLATWLRRRGGWT-DVLK----------------------------CVVSTDP---GYRSHW-------------------------------------------------LVAAF D_melanogaster_FBpp0087182 I-EDELVPWINENGGWS-GINT----------------------------HVLPTTN--SLNPLEW-------------------------------------------------TTLVI D_melanogaster_FBpp0085443 I-EDDLVYWLIDNGGWL-GLSR----------------------------HIRPRVG--EFTFLGW-------------------------------------------------LTLFV A_aegypti_AAEL001521-PA I-EDELVTWISENGGWV-GLAN----------------------------KVRPPQE--EITFAGR-------------------------------------------------CFVGA A_aegypti_AAEL001515-PA I-EEDLSLWLVEKGGWL-GLHD----------------------------HVHPPQT--EITFLGW-------------------------------------------------MAITI A_gambiae_AGAP011552-PA I-EEDLSGWLVERGGWL-GLQD----------------------------HVHPPQP--EISVTGW-------------------------------------------------VSITA C_intestinalis_ENSCINP00000019812 I-QRNALDWIIKHGGWG-GLVD----------------------------NFSPKPM--KSYWSTRNILK---------------------------------------------WNGGV C_intestinalis_ENSCINP00000016140 ASEEGVLRWIVSQGGWE-TLRE----------------------------MTDDHSA--SHTANDYG------------------------------------------------YLTHI D_rerio_ENSDARP00000089067 M-KKHISAWIRQQGGWE-GIFR----------------------------SMTRW------------------------------------------------------------RTVST D_rerio_ENSDARP00000095258 L-DNHIQPWIQSQGGWE-RFAE----------------------------IFGKDAA--AESRKSQE----SFKKW---------------------------------------LFAGM X_tropicalis_ENSXETP00000052058 L-NSHLQNWIQEQGGWD-AFVE----------------------------LYNSNIR--PPFDPSWL----SIKTI---------------------------------------LSLAV T_nigroviridis_ENSTNIP00000017211 I-REQLYSWLVQQGGWA-GVIQ----------------------------RFARW------------------------------------------------------------RVAAV