CYLD-1 (Caenorhabditis elegans)
Description [+]
- Synonyms: CYLD-1
- Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
- Short gene description: F40F12.5 encodes an ortholog of human CYLD1 (OMIM:605018, mutated in cylindromatosis). CYLD1 binds several members of the NF-kappaB signalling pathway, and can deubiquitinate target proteins. [Source: WormBase]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: CYLD-1-C_elegans
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
| Source | Domain Name | Start | End |
|---|---|---|---|
| PFAM A | CAP_GLY | 460 | 528 |
Protein sequence [+]
cyld-1 | Caenorhabditis elegans | 6239 | length:1144
MPGEFAKFPEQSAGSHQFRNPLDELTGSNTITNLTAHDFDYFTQSEKNSNLYTSENTSNS
NRLNLNQNIPVGTLIDGFELINEASGSGFLDDQLVDVSDYSRDRTTKLDRNRNSPELIVA
LLQRKVQGIRFSSNYGREEEPCVIEIPPGTMVREMADDDWKMSELKEWFTKSRASSHLRD
GLAMPMEELDCTPLICAMITRSDVMRINQDQAIHLLAVSVEKRIEVYQNFEWFNFILNLK
IGDSVSVEVDETMRRVPAKVSWIGERPEASGIWYNVDFDGNTSQWPSSNQSYSSSHDRLN
RQFDTNWNFEMSGSSSVAPSNSRLYYSPNQMHMPMKGGGVSALYDNRRLVQYSGDEEQYR
SAPKPAPRERIIPVSRQQPEIEQRNSRSMKPSEPDYNTYSTHPPRPPPSSSMNYPSMSNT
HSLQPSRSKSVQTIQRNQFVRQNPAERNERVESDQLNFRIGDQCIWNNNGAEERGIIKYI
GFLKGHKTLYAGVEFKNTIGAGTGVFNREQLFLAKDGHAGFVELSSLESPSSSISSTSTS
SSQHRRRLSSSRSQQMPAASGTSISVPVNGRHNVNGKQASIESLSDPPPPPYAPPSPPRA
SSAAAAHQQPPPLPPKPLARVEDFLIDSYDIGSHVVVRHLGAQRTGVVRWLGEEIDDEGD
RIVRSAIVQLDEDVPTAWRRSHDASSYTGSPVVGGVLVPIQSLKHNHSGSSSNGASVVQT
STYPTSQTYNNISRRTEDFGSMDSGVEKQKCGIAKDMQQLVGRQKGIQGYCNSCYLDATL
YAMFVQTTCFDFLLEKSIKGSETAQQFQKILAHEIVFPLRKVHYVRADHVMKLRKLLAEL
MPHVTGLTNEEKDPEEILGFIFSKVFHAEPFIKLIGQNHAKDSQYLVPIVVDDWLGGAAT
SQHLLERHMRSAQVTFAKAPPVLIMQLPRYGQQKVFDKILPLETIDITPFVAGAVPACSK
CQACSEVYCPTCFLTRRVFYSEVIFCRKCFHHTHLLPEIEDHKSRDLYPPGKPQKKPHSH
KMVLSAVLCIETSHYVAYVRTSSNQWVFFDSMADREGLSDGFNVPVVRECGNMSDWLSLQ
GWNRLKDADECGQIKAMFGKQSSLDPLVGRLLSDSYICFYEDASPTSSSSSSSTIISSIK
NMMN
NRLNLNQNIPVGTLIDGFELINEASGSGFLDDQLVDVSDYSRDRTTKLDRNRNSPELIVA
LLQRKVQGIRFSSNYGREEEPCVIEIPPGTMVREMADDDWKMSELKEWFTKSRASSHLRD
GLAMPMEELDCTPLICAMITRSDVMRINQDQAIHLLAVSVEKRIEVYQNFEWFNFILNLK
IGDSVSVEVDETMRRVPAKVSWIGERPEASGIWYNVDFDGNTSQWPSSNQSYSSSHDRLN
RQFDTNWNFEMSGSSSVAPSNSRLYYSPNQMHMPMKGGGVSALYDNRRLVQYSGDEEQYR
SAPKPAPRERIIPVSRQQPEIEQRNSRSMKPSEPDYNTYSTHPPRPPPSSSMNYPSMSNT
HSLQPSRSKSVQTIQRNQFVRQNPAERNERVESDQLNFRIGDQCIWNNNGAEERGIIKYI
GFLKGHKTLYAGVEFKNTIGAGTGVFNREQLFLAKDGHAGFVELSSLESPSSSISSTSTS
SSQHRRRLSSSRSQQMPAASGTSISVPVNGRHNVNGKQASIESLSDPPPPPYAPPSPPRA
SSAAAAHQQPPPLPPKPLARVEDFLIDSYDIGSHVVVRHLGAQRTGVVRWLGEEIDDEGD
RIVRSAIVQLDEDVPTAWRRSHDASSYTGSPVVGGVLVPIQSLKHNHSGSSSNGASVVQT
STYPTSQTYNNISRRTEDFGSMDSGVEKQKCGIAKDMQQLVGRQKGIQGYCNSCYLDATL
YAMFVQTTCFDFLLEKSIKGSETAQQFQKILAHEIVFPLRKVHYVRADHVMKLRKLLAEL
MPHVTGLTNEEKDPEEILGFIFSKVFHAEPFIKLIGQNHAKDSQYLVPIVVDDWLGGAAT
SQHLLERHMRSAQVTFAKAPPVLIMQLPRYGQQKVFDKILPLETIDITPFVAGAVPACSK
CQACSEVYCPTCFLTRRVFYSEVIFCRKCFHHTHLLPEIEDHKSRDLYPPGKPQKKPHSH
KMVLSAVLCIETSHYVAYVRTSSNQWVFFDSMADREGLSDGFNVPVVRECGNMSDWLSLQ
GWNRLKDADECGQIKAMFGKQSSLDPLVGRLLSDSYICFYEDASPTSSSSSSSTIISSIK
NMMN
Evolution [+]
Explore tree at phylomeDB: Click here.
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Information from other databases [+]
- entrezgene: 176401
- refseq_dna: NM_001027399
- refseq_peptide: NP_001022570
- uniprot_sptrembl: Q7JMS4
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