CASP8 (Macaca mulatta)
Description [+]
- Synonyms: CASP8
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Cercopithecidae; Macaca mulatta
- Short gene description: Caspase-8 Precursor (CASP-8)(EC 3.4.22.61)(ICE-like apoptotic protease 5)(MORT1-associated CED-3 homolog)(MACH)(FADD-homologous ICE/CED-3-like protease)(FADD-like ICE)(FLICE)(Apoptotic cysteine protease)(Apoptotic protease Mch-5)(CAP4) [Contains Caspase-8 subunit p18;Caspase-8 subunit p10] [Source:UniProtKB/Swiss-Prot;Acc:Q14790]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: CASP8-M_mulatta
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | DED | 62 | 145 |
PFAM A | DED | 160 | 242 |
PFAM A | Peptidase_C14 | 293 | 535 |
Protein sequence [+]
CASP8 | Macaca mulatta | 9544 | length:538
VEGGRRARVVTESKRNFFLGACPTPFPTEHVELGRLGGSETAMVPGKGGADYILLPFEEM
DFNRNLYDIGEQLDSEELASLKFLSLDCIPQRKQEPIKDALMLFQRLQEKRMLEENNLSF
LKELLFRINRLDLLTTYLNTRKEEMERELQAPGRAQISAYRVMLYQISEEVGRSELRSFK
FLLQEEISKCKLDDDMNLLDIFVEMEKRVILGEGKLDILKRVCAQVNKSLLKIINDYEEF
SRERTRSLEGSPEEGSNGEELCGLMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINN
YDFTKAREKVPKLHSIRDRNGTHLDAEALTATFEELHFEIQHHNDCTVEKIYKILKTYQL
MDHSNKDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQ
GDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWY
IQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
DFNRNLYDIGEQLDSEELASLKFLSLDCIPQRKQEPIKDALMLFQRLQEKRMLEENNLSF
LKELLFRINRLDLLTTYLNTRKEEMERELQAPGRAQISAYRVMLYQISEEVGRSELRSFK
FLLQEEISKCKLDDDMNLLDIFVEMEKRVILGEGKLDILKRVCAQVNKSLLKIINDYEEF
SRERTRSLEGSPEEGSNGEELCGLMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINN
YDFTKAREKVPKLHSIRDRNGTHLDAEALTATFEELHFEIQHHNDCTVEKIYKILKTYQL
MDHSNKDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQ
GDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWY
IQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Structure links:
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0006508 | proteolysis | biological_proccess | IEA |
GO:0042981 | regulation of apoptosis | biological_proccess | IEA |
GO:0006915 | apoptosis | biological_proccess | IEA |
GO:0006955 | immune response | biological_proccess | IEA |
GO:0009405 | pathogenesis | biological_proccess | IEA |
GO:0007507 | heart development | biological_proccess | IEA |
GO:0001525 | angiogenesis | biological_proccess | IEA |
GO:0001841 | neural tube formation | biological_proccess | IEA |
GO:0030225 | macrophage differentiation | biological_proccess | IEA |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | biological_proccess | IEA |
GO:0034612 | response to tumor necrosis factor | biological_proccess | IEA |
GO:0051603 | proteolysis involved in cellular protein catabolic process | biological_proccess | IEA |
GO:0008624 | induction of apoptosis by extracellular signals | biological_proccess | IEA |
GO:0004197 | cysteine-type endopeptidase activity | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IEA |
GO:0008234 | cysteine-type peptidase activity | mollecular_function | IEA |
GO:0005126 | hematopoietin/interferon-class (D200-domain) cytokine receptor binding | mollecular_function | IEA |
GO:0008083 | growth factor activity | mollecular_function | IEA |
GO:0004308 | exo-alpha-sialidase activity | mollecular_function | IEA |
GO:0008233 | peptidase activity | mollecular_function | IEA |
GO:0042802 | identical protein binding | mollecular_function | IEA |
GO:0005576 | extracellular region | cell_component | IEA |
GO:0005634 | nucleus | cell_component | IEA |
GO:0005737 | cytoplasm | cell_component | IEA |
GO:0030690 | Noc1p-Noc2p complex | cell_component | IEA |
GO:0031264 | death-inducing signaling complex | cell_component | IEA |
Check GO Evidence Codes here
Information from other databases [+]
- Ensembl genome browser [?] : ENSMMUG00000031296
- Expression info from Arrayexpress [?] : ENSMMUG00000031296
- Protein expression from Protein Atlas: [?] ENSMMUG00000031296
Click on [?] for more information.