FAS (Mus musculus)

Description [+]

Synonyms: FAS, FAS, FAS (TNF RECEPTOR SUPERFAMILY MEMBER 6)
Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Rodentia; Mus musculus
Short gene description: Tumor necrosis factor receptor superfamily member 6 Precursor (FASLG receptor)(Apoptosis-mediating surface antigen FAS)(Apo-1 antigen)(CD95 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P25446]
Family: death receptor
Process: apoptosis,
Pathways: extrinsic pathway,
Criteria: manually curated
Curator comment:
WIKI: FAS-M_musculus

References [+]

Structure & Sequence [+]

Pfam domains: (Pfam is a large collection of protein families.)

Source	Domain Name	Start	End
PFAM A	TNFR_c6	44	78
PFAM A	TNFR_c6	81	123
PFAM A	TNFR_c6	125	161
PFAM A	Death	223	306

Protein sequence [+]

Structure links:

Smartdomain prediction information: SM00208
Smartdomain prediction information: SM00005
Prosite motif and domain information: PS00652
Interpro domain information: P25446
PFAM domain and domain family information: P25446

Evolution [+]

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0007165	signal transduction	biological_proccess	IEA
GO:0006915	apoptosis	biological_proccess	IEA
GO:0006955	immune response	biological_proccess	IEA
GO:0002377	immunoglobulin production	biological_proccess	IMP
GO:0003014	renal system process	biological_proccess	IMP
GO:0006924	activation-induced cell death of T cells	biological_proccess	IMP
GO:0006925	inflammatory cell apoptosis	biological_proccess	IDA
GO:0006927	transformed cell apoptosis	biological_proccess	IDA
GO:0008625	induction of apoptosis via death domain receptors	biological_proccess	IMP
GO:0009636	response to toxin	biological_proccess	IMP
GO:0010467	gene expression	biological_proccess	IMP
GO:0019724	B cell mediated immunity	biological_proccess	IMP
GO:0043065	positive regulation of apoptosis	biological_proccess	IGI
GO:0043066	negative regulation of apoptosis	biological_proccess	IDA
GO:0045060	negative thymic T cell selection	biological_proccess	IMP
GO:0045619	regulation of lymphocyte differentiation	biological_proccess	IMP
GO:0045637	regulation of myeloid cell differentiation	biological_proccess	IMP
GO:0048536	spleen development	biological_proccess	IMP
GO:0050869	negative regulation of B cell activation	biological_proccess	IMP
GO:0051260	protein homooligomerization	biological_proccess	IDA
GO:0051384	response to glucocorticoid stimulus	biological_proccess	IMP
GO:0051789	response to protein stimulus	biological_proccess	IMP
GO:0006915	apoptosis	biological_proccess	IMP
GO:0008624	induction of apoptosis by extracellular signals	biological_proccess	IDA
GO:0043029	T cell homeostasis	biological_proccess	IMP
GO:0007568	aging	biological_proccess	IEA
GO:0043434	response to peptide hormone stimulus	biological_proccess	IEA
GO:0001666	response to hypoxia	biological_proccess	IEA
GO:0010035	response to inorganic substance	biological_proccess	IEA
GO:0042493	response to drug	biological_proccess	IEA
GO:0009636	response to toxin	biological_proccess	IEA
GO:0043627	response to estrogen stimulus	biological_proccess	IEA
GO:0007283	spermatogenesis	biological_proccess	IEA
GO:0034097	response to cytokine stimulus	biological_proccess	IEA
GO:0032496	response to lipopolysaccharide	biological_proccess	IEA
GO:0008625	induction of apoptosis via death domain receptors	biological_proccess	IEA
GO:0042698	ovulation cycle	biological_proccess	IEA
GO:0005515	protein binding	mollecular_function	IEA
GO:0004872	receptor activity	mollecular_function	IEA
GO:0004888	transmembrane receptor activity	mollecular_function	IEA
GO:0016020	membrane	cell_component	IEA
GO:0005576	extracellular region	cell_component	IDA
GO:0009897	external side of plasma membrane	cell_component	IDA
GO:0016021	integral to membrane	cell_component	IEA
GO:0009986	cell surface	cell_component	IDA
GO:0005901	caveola	cell_component	IEA
GO:0048471	perinuclear region of cytoplasm	cell_component	IEA

Check GO Evidence Codes here

KEGG Pathways [+]

Information from other databases [+]

Gene related links:

Gene info from MGI [?] MGI:95484
Ensembl genome browser [?] : ENSMUSG00000024778
Expression info from Arrayexpress [?] : ENSMUSG00000024778
Protein expression from Protein Atlas: [?] ENSMUSG00000024778
Community gene edition from Wikigenes: [?] 14102

Protein related links:

Uniprot protein info: P25446
PIR protein info: P25446
Protein interactions from IntAct: P25446

Other links

entrezgene: 14102
refseq_dna: NM_007987
refseq_peptide: NP_032013

Click on [?] for more information.