TNFRSF1A (Mus musculus)

Description [+]

Synonyms: TNFRSF1A, TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A, CD120A, P55, P55-R, TNF RECEPTOR ALPHA CHAIN, TNF-ALPHA-R1, TNF-ALPHAR1, TNF-R-I, TNF-R1, TNF-R55, TNFALPHA-R1, TNFAR, TNFR-2, TNFR1, TNFR60, TNFRI, TNFRP55
Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Rodentia; Mus musculus
Short gene description: Tumor necrosis factor receptor superfamily member 1A Precursor (p60)(TNF-R1)(TNF-RI)(TNFR-I)(p55)(CD120a antigen) [Source:UniProtKB/Swiss-Prot;Acc:P25118]
Family: death receptor
Process: apoptosis, necroptosis,
Pathways: extrinsic pathway, TNF/NF-kappaB signaling,
Criteria: manually curated
Curator comment:
WIKI: TNFRSF1A-M_musculus

References [+]

Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor.
Goodwin RG, Anderson D, Jerzy R, Davis T, Brannan CI, Copeland NG, Jenkins NA, Smith CA
Clones encoding the type 1 (p80) and type 2 (p60) forms of the murine receptors for tumor necrosis factor (TNF) were isolated by cross-hybridization using probes derived from the cloned human TNF receptors. Each of the murine receptors shows strong sequence homology to the corresponding human receptor (approximately 65% amino acid identity) throughout the molecule but only modest homology, limited to ligand-binding domains, between themselves. The ligand-binding characteristics of the recombinant murine receptors mirror those of the human homologs: both receptor types bind TNF-alpha and -beta with multiple affinity classes, and the ligands cross-compete. Analysis of the murine transcripts encoding these receptors revealed the presence of RNAs for one or both forms of the receptors in all cells examined. It was also demonstrated that for both types of human TNF receptor, variably sized transcripts are observed in different cells. The murine cDNAs were further used to determine the chromosomal locations of the TNF receptor genes. They are not linked, in contrast to the ligands, and map to chromosomes 4 (type 1) and 6 (type 2). Mol Cell Biol. 1991 Jun;11(6):3020-6.

The two different receptors for tumor necrosis factor mediate distinct cellular responses.
Tartaglia LA, Weber RF, Figari IS, Reynolds C, Palladino MA Jr, Goeddel DV
The individual roles of the murine type 1 and type 2 tumor necrosis factor (TNF) receptors (TNF-R1 and TNF-R2) were investigated utilizing (i) the strong species specificity of TNF-R2 for murine TNF compared to human TNF and (ii) agonistic rabbit polyclonal antibodies directed against the individual TNF receptors. Proliferation of mouse thymocytes and the murine cytotoxic T-cell line CT-6 is stimulated by murine TNF but not by human TNF. Consistent with this observation, polyclonal antibodies directed against TNF-R2 induced proliferation in both of these cell types, whereas polyclonal antibodies directed against TNF-R1 had no effect. In contrast, cytotoxicity in murine LM cells (which are sensitive to murine and human TNF) was induced by antibodies against TNF-R1 but not by antibodies against TNF-R2. Also, the steady-state level of manganous superoxide dismutase mRNA in the murine NIH 3T3 cell line was induced by murine TNF, human TNF, and anti-TNF-R1 but not by anti-TNF-R2. These results suggest that TNF-R2 initiates signals for the proliferation of thymocytes and cytotoxic T cells, whereas TNF-R1 initiates signals for cytotoxicity and the induction of the protective activity, manganous superoxide dismutase. The nonredundant signaling observed for the two TNF receptors cannot be explained simply by the differential expression of the two TNF receptors in the various cell types, because LM cells express on their surface higher levels of TNF-R2 than TNF-R1, and LM cells, NIH 3T3 cells, and thymus cells all express mRNA corresponding to both receptor types. It is therefore likely that the two receptors initiate distinct signaling pathways that result in the induction of different cellular responses. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9292-6.

Structure & Sequence [+]

Pfam domains: (Pfam is a large collection of protein families.)

Source	Domain Name	Start	End
PFAM A	TNFR_c6	44	81
PFAM A	TNFR_c6	84	125
PFAM A	TNFR_c6	127	166
PFAM A	Death	357	441

Protein sequence [+]

Structure links:

Smartdomain prediction information: SM00208
Smartdomain prediction information: SM00005
Prosite motif and domain information: PS00652
Prosite motif and domain information: PS01186
Interpro domain information: P25118
PFAM domain and domain family information: P25118

Evolution [+]

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0006693	prostaglandin metabolic process	biological_proccess	TAS
GO:0006915	apoptosis	biological_proccess	IEA
GO:0019221	cytokine-mediated signaling pathway	biological_proccess	IMP
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological_proccess	IMP
GO:0050729	positive regulation of inflammatory response	biological_proccess	IMP
GO:0007166	cell surface receptor linked signal transduction	biological_proccess	IMP
GO:0006952	defense response	biological_proccess	IMP
GO:0006954	inflammatory response	biological_proccess	IMP
GO:0007165	signal transduction	biological_proccess	IEA
GO:0009816	defense response to bacterium, incompatible interaction	biological_proccess	IMP
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	biological_proccess	IEA
GO:0051291	protein heterooligomerization	biological_proccess	IEA
GO:0045471	response to ethanol	biological_proccess	IEA
GO:0032496	response to lipopolysaccharide	biological_proccess	IEA
GO:0045766	positive regulation of angiogenesis	biological_proccess	IEA
GO:0004872	receptor activity	mollecular_function	IEA
GO:0005031	tumor necrosis factor receptor activity	mollecular_function	IMP
GO:0005515	protein binding	mollecular_function	IPI
GO:0005515	protein binding	mollecular_function	IEA
GO:0032403	protein complex binding	mollecular_function	IEA
GO:0005031	tumor necrosis factor receptor activity	mollecular_function	TAS
GO:0005886	plasma membrane	cell_component	TAS
GO:0016021	integral to membrane	cell_component	IEA
GO:0045121	membrane raft	cell_component	IDA
GO:0016020	membrane	cell_component	IEA
GO:0045121	membrane raft	cell_component	IEA
GO:0043234	protein complex	cell_component	IEA

Check GO Evidence Codes here

KEGG Pathways [+]

Curated Isoforms [+]

Transcript	Translation
OTTMUST00000084343
OTTMUST00000058165 *	OTTMUSP00000028139 *
OTTMUST00000058191	OTTMUSP00000028161
OTTMUST00000058192	OTTMUSP00000045442
OTTMUST00000058193
OTTMUST00000058194	OTTMUSP00000028163

Information from other databases [+]

Gene related links:

Gene info from MGI [?] MGI:1314884
Ensembl genome browser [?] : ENSMUSG00000030341
Expression info from Arrayexpress [?] : ENSMUSG00000030341
Protein expression from Protein Atlas: [?] ENSMUSG00000030341
Community gene edition from Wikigenes: [?] 21937

Protein related links:

Uniprot protein info: P25118
PIR protein info: P25118
Protein interactions from IntAct: P25118

Other links

entrezgene: 21937
refseq_dna: NM_011609
refseq_peptide: NP_035739

Click on [?] for more information.