TNFRSF21 (Danio rerio)
Description [+]
- Synonyms: TNFRSF21, TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21, DR6, IM:6795346, WU:FA55E01, WU:FB02E11, WU:FC29A09, WU:FI27H08
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Pisces; Danio rerio
- Short gene description: tumor necrosis factor receptor superfamily, member 21 [Source:RefSeq_peptide;Acc:NP_001036153]
- Family: Death receptor
- Process: undefined,
- Pathways: extrinsic pathway,
- Criteria: manually curated
- Curator comment: Expression detected in regions of the developing zebrafish central nervous system [16888647] .
- Human ortholog(s): TNFRSF21
- WIKI: TNFRSF21-D_rerio
References [+]
- Delineation of the cell-extrinsic apoptosis pathway in the zebrafish.
- Eimon PM, Kratz E, Varfolomeev E, Hymowitz SG, Stern H, Zha J, Ashkenazi A
- The mammalian extrinsic apoptosis pathway is triggered by Fas ligand (FasL) and Apo2 ligand/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL). Ligand binding to cognate receptors activates initiator caspases directly in a death-inducing signaling complex. In Drosophila, TNF ligand binding activates initiator caspases indirectly, through JNK. We characterized the extrinsic pathway in zebrafish to determine how it operates in a nonmammalian vertebrate. We identified homologs of FasL and Apo2L/TRAIL, their receptors, and other components of the cell death machinery. Studies with three Apo2L/TRAIL homologs demonstrated that they bind the receptors zHDR (previously linked to hematopoiesis) and ovarian TNFR (zOTR). Ectopic expression of these ligands during embryogenesis induced apoptosis in erythroblasts and notochord cells. Inhibition of zHDR, zOTR, the adaptor zFADD, or caspase-8-like proteases blocked ligand-induced apoptosis, as did antiapoptotic Bcl-2 family members. Thus, the extrinsic apoptosis pathway in zebrafish closely resembles its mammalian counterpart and cooperates with the intrinsic pathway to trigger tissue-specific apoptosis during embryogenesis in response to ectopic Apo2L/TRAIL expression. Cell Death Differ. 2006 Oct;13(10):1619-30. Epub 2006 Aug 4.
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
| Source | Domain Name | Start | End |
|---|---|---|---|
| PFAM A | TNFR_c6 | 78 | 118 |
| PFAM A | Death | 403 | 485 |
Protein sequence [+]
tnfrsf21 | Danio rerio | 7955 | length:637
MPGKMSLIWSLTLLLTVVGDVLTHTLTPIPTTEKPLSPRHYHHIDPATGNKLVCDKCPAG
TYVSSHCTEASVRECSPCPDGTFTRGENGVQQCHRCQRRCQAPFIEKTPCTSTTDRLCVC
PPGSFSQDGKCQRHSSCLPGWGVRKRGSETEDVRCQPCQRGTFSAITSDSLRCQTHTDCP
ALGLTLLIKGTKKTDNVCGPNPASSVPVLLGEASVSTVSSTESAYRASTAVLPAADIQDE
AEPVFSSTDMALGAQNFPTTTAYPEAIDKDGGLLIAATQDLPKSKLKLTLSRDLQLSNHQ
GVESMSESKAQGLGYRPIRRGAPRPSSHKHFDINEHLPWMIVLLLLLVLVVIVVCSVKRS
SRVLKKGPRQDPSSIMEKAIHKKPSSPAQTKERWIYYSNGQGVDILKLVAAQIGSQWIDL
YKSLASATEREVAAFSNGYTADHERAYAALQHWTIRDSDANLAKLINALHRQRRIDVVDK
IRSVMEDNPQVDLNKLMTAVNVSHCLSPSHKPLESPGVAVEQSPMERSRGFFPDESEPLL
RCDSTSSKDSALSRTGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHILNPDELHVIEEI
PMAEDKLDRLFEIAGVKSQEASQTLLDSVYSHLPDLL
TYVSSHCTEASVRECSPCPDGTFTRGENGVQQCHRCQRRCQAPFIEKTPCTSTTDRLCVC
PPGSFSQDGKCQRHSSCLPGWGVRKRGSETEDVRCQPCQRGTFSAITSDSLRCQTHTDCP
ALGLTLLIKGTKKTDNVCGPNPASSVPVLLGEASVSTVSSTESAYRASTAVLPAADIQDE
AEPVFSSTDMALGAQNFPTTTAYPEAIDKDGGLLIAATQDLPKSKLKLTLSRDLQLSNHQ
GVESMSESKAQGLGYRPIRRGAPRPSSHKHFDINEHLPWMIVLLLLLVLVVIVVCSVKRS
SRVLKKGPRQDPSSIMEKAIHKKPSSPAQTKERWIYYSNGQGVDILKLVAAQIGSQWIDL
YKSLASATEREVAAFSNGYTADHERAYAALQHWTIRDSDANLAKLINALHRQRRIDVVDK
IRSVMEDNPQVDLNKLMTAVNVSHCLSPSHKPLESPGVAVEQSPMERSRGFFPDESEPLL
RCDSTSSKDSALSRTGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHILNPDELHVIEEI
PMAEDKLDRLFEIAGVKSQEASQTLLDSVYSHLPDLL
Structure links:
Evolution [+]
View protein alignment and tree with Jalview:
Explore tree at phylomeDB: Click here.
Homologs list [+]
| Name | Relationship | Species |
|---|---|---|
| TNFRSF21 | orthology | Chicken |
| TNFRSF21 | orthology | Chimpanzee |
| LOC785024 | orthology | Cow |
| NP_001070379.1 | orthology | Cow |
| C_familiaris_ENSCAFP00000032150 | orthology | Dog |
| C_familiaris_ENSCAFP00000003059 | orthology | Dog |
| TNFRSF21 | orthology | Fugu |
| TNFRSF21 | orthology | Gasterosteus |
| TNFRSF21 | orthology | Gorilla |
| TNFRSF21 | orthology | Horse |
| TNFRSF21 | orthology | Human |
| TNFRSF21 | orthology | Lyzard |
| TNFRSF21 | orthology | Macaca |
| TNFRSF21 | orthology | Medaka |
| TNFRSF21 | orthology | Monodelphis |
| Tnfrsf21 | orthology | Mouse |
| TNFRSF21 | orthology | Orangutan |
| TNFRSF21 | orthology | Ornithorhynchus |
| TNFRSF21 | orthology | Rabbit |
| NP_001101677.1 | orthology | Rat |
| TNFRSF21 | orthology | Tetraodon |
| TNFRSF21 | orthology | Xenopus |
| TNFRSF21 | orthology | Zebra finch |
| TNR5_BOVIN | paralogy | Cow |
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Gene Ontology [+]
| GO id | Name | Ontology type | Evidence |
|---|---|---|---|
| GO:0007165 | signal transduction | biological_proccess | IEA |
| GO:0005515 | protein binding | mollecular_function | IEA |
| GO:0004872 | receptor activity | mollecular_function | IEA |
Check GO Evidence Codes here
Information from other databases [+]
- Gene info from ZFIN [?] ZDB-GENE-030131-5971
- Ensembl genome browser [?] : ENSDARG00000001807
- Expression info from Arrayexpress [?] : ENSDARG00000001807
- Protein expression from Protein Atlas: [?] ENSDARG00000001807
- Community gene edition from Wikigenes: [?] 564874
- entrezgene: 564874
- refseq_dna: NM_001042688
- refseq_peptide: NP_001036153
Click on [?] for more information.
