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CED-4   (Caenorhabditis elegans)

Description [+]
  • Synonyms: CED-4
  • Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
  • Short gene description: ced-4 encodes a novel protein. along with CED-3, CED-4 is required for the initiation of programmed cell death. accordingly, genetic analyses indicate that ced-3 and ced-4 function upstream of ced-1, ced-2, and nuc-1 in the programmed cell death pathway. in yeast two-hybrid experiments, and upon coexpression in mammalian cells, CED-4 interacts with CED-9, an anti-apoptotic BCL-2 homolog. coexpression of CED-4 and CED-9 results in redistribution of CED-4 from the cytosol to organellar membranes, suggesting that CED-9 may negatively regulate CED-4 activity by sequestering CED-4 to intracellular membranes. [Source: WormBase]
  • Family: CARD-containing protein : CARD adapter protein
  • Process: apoptosis,
  • Pathways:
  • Criteria: manually curated
  • Curator comment:
  • WIKI: CED-4-C_elegans
References [+]
Structure & Sequence [+]
Evolution [+]
Gene Ontology [+]
Information from other databases [+]