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CASP9   (Homo sapiens)

Description [+]
  • Synonyms: CASP9, CASPASE-9, CASPASE 9, CASP9, MCH6, ICE-LAP6, APAF-3
  • Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
  • Short gene description: Caspase-9 Precursor (CASP-9)(EC apoptotic protease 6)(ICE-LAP6)(Apoptotic protease Mch-6)(Apoptotic protease-activating factor 3)(APAF-3) [Contains Caspase-9 subunit p35;Caspase-9 subunit p10] [Source:UniProtKB/Swiss-Prot;Acc:P55211]
  • Family: Caspase
  • Process: apoptosis,
  • Pathways: intrinsic pathway,
  • Criteria: manually curated
  • Curator comment: Caspase-9 is the binding partner of Apaf-1, becoming activated upon binding to the latter in response to mitochondrial cytochrome c efflux. Apaf-1 and caspase-9 form a holoenzyme (called the apoptosome) which is comprised of seven molecules of Apaf-1 and possibly a similar number of caspase-9 molecules (although the precise number of caspase-9 molecules within the apoptosome may be as low as 1 or 2). Upon activation within the apoptosome, caspase-9 then directly processes and activates caspases -3 and -7 downstream. Other than caspases -3 and -7, few other substrates for caspase-9 are known.
  • Mouse ortholog(s): Casp9
  • WIKI: CASP9-H_sapiens
References [+]
Structure & Sequence [+]
Evolution [+]
Gene Ontology [+]
KEGG Pathways [+]
miRNAs [+]
Curated Isoforms [+]
Information from other databases [+]