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CASP1   (Homo sapiens)

Description [+]
  • Synonyms: CASP1, ICE, CASPASE-1, CASPASE 1, CASP1
  • Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
  • Short gene description: Caspase-1 Precursor (CASP-1)(EC beta convertase)(IL-1BC)(Interleukin-1 beta-converting enzyme)(IL-1 beta-converting enzyme)(ICE)(p45) [Contains Caspase-1 subunit p20;Caspase-1 subunit p10] [Source:UniProtKB/Swiss-Prot;Acc:P29466]
  • Family: Caspase
  • Process: immunity,
  • Pathways: inflammasome,
  • Criteria: manually curated
  • Curator comment: Caspase-1 is instrumental in processing the precursor forms of interleukin-1beta and interleukin-18 to their biologically active forms. Although quite a few other substrates for caspase-1 have been claimed, these have invariably been found using non-physiological concentrations of caspase-1 (i.e. at concentrations in excess of 200 nanoMolar, sometimes ridiculously so) and are therefore unlikely to be genuine substrates. So, to date, there are two natural substrates for caspase-1 known (IL-1beta and IL-18).
  • Mouse ortholog(s): Casp1
  • WIKI: CASP1-H_sapiens
References [+]
Structure & Sequence [+]
Evolution [+]
Gene Ontology [+]
KEGG Pathways [+]
Curated Isoforms [+]
Information from other databases [+]