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MCL1B   (Danio rerio)

Description [+]
  • Synonyms: MCL1B, MYELOID CELL LEUKEMIA SEQUENCE 1B, ZGC:109763
  • Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Pisces; Danio rerio
  • Short gene description: myeloid cell leukemia sequence 1b [Source:RefSeq_peptide;Acc:NP_919375]
  • Family: Bcl-2 family : multidomain Bcl-2
  • Process: apoptosis,
  • Pathways: intrinsic pathway, pre-mitochondrial signaling events,
  • Criteria: manually curated
  • Curator comment: Ectopic expression of Mcl1b in zebrafish embryos inhibits apoptosis induced by several pro-apoptotic Bcl2 family members [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ] and gamma-irradiation [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ]. Simultaneous knockdown of both Mcl1a and Mcl1b in zebrafish embryos using antisense morpholino oligonucleotides significantly decreases viability and increases sensitivity to apoptosis induced by the Apo2L/TRAIL ortholog Tnfsf10l3 [ Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 "> Ref: Ref: 16888646 ].
  • Human ortholog(s): MCL1
  • WIKI: MCL1B-D_rerio
References [+]
Structure & Sequence [+]
Evolution [+]
Gene Ontology [+]
Information from other databases [+]