BCL2 (Mus musculus)
Description [+]
- Synonyms: BCL2, BCL2, B-CELL LEUKEMIA/LYMPHOMA 2
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Rodentia; Mus musculus
- Short gene description: B-cell leukemia/lymphoma 2 Gene [Source:MGI (curated);Acc:Bcl2-001]
- Family: Bcl-2 family : multidomain Bcl-2
- Process: apoptosis,
- Pathways: intrinsic pathway, pre-mitochondrial signaling events,
- Criteria: manually curated
- Curator comment:
- Human ortholog(s): BCL2
- WIKI: BCL2-M_musculus
References [+]
- Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma.
- Negrini M, Silini E, Kozak C, Tsujimoto Y, Croce CM
- We have cloned the mouse bcl-2 (mbcl-2) genomic locus and analyzed it in detail. The gene is comprised of two exons separated by more than 15 kb. Two species of mRNAs are produced, and DNA sequencing analysis shows that they code for two proteins differing at their C terminus: a 7.5 kb transcript codes for a polypeptide of 236 amino acids, mbcl-2 alpha, and a 2.4 kb transcript, which derives from the 5' exon only, codes for a protein of 199 amino acids, mbcl-2 beta. The gene is characterized by very long (5' about 1.4 kb, and 3' about 5.1 kb) untranslated regions surrounding the relatively short coding region. We have mapped the 5' end of the mbcl-2 mRNAs by S1 protection analysis, and we have analyzed the promoter region. The expression of the mbcl-2 gene was analyzed in different cell lines and in mouse tissues. Expression is tissue-specific in adult tissues: spleen and thymus express the highest level of mbcl-2 transcripts. The mbcl-2 gene maps to mouse chromosome 1. Cell. 1987 May 22;49(4):455-63.
- References from Human ortholog(s):
- Oncogenic potential of bcl-2 demonstrated by gene transfer.
- Reed JC, Cuddy M, Slabiak T, Croce CM, Nowell PC
- Follicular lymphoma is the most common human B-cell malignancy in the United States and Western Europe. Most of the tumours contain t(14;18) chromosome translocations involving the human bcl-2 gene. Translocation of bcl-2 sequences from chromosome 18 into the transcriptionally active immunoglobulin locus at chromosome band 14q32 in B cells deregulates bcl-2 gene expression, resulting in the accumulation of high levels of bcl-2 messenger. Human bcl-2 transcripts generate two proteins, p26 bcl-2-alpha and p22 bcl-2-beta, by virtue of alternative splice-site selection. Both proteins have in common their first 196 NH2-terminal amino acids but share little similarity with other sequences in a data bank. Although the biological and biochemical functions of bcl-2 are unknown, recent subcellular localization studies indicate that p26 bcl-2-alpha associates with cellular membranes, consistent with a stretch of hydrophobic amino acids in its carboxy terminus. The bcl-2 gene may represent a novel oncogene having no known retroviral counterpart. Here we demonstrate the oncogenic potential of bcl-2 through a gene transfer approach. Nature. 1988 Nov 17;336(6196):259-61.
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | BH4 | 7 | 33 |
PFAM A | Bcl-2 | 94 | 192 |
Protein sequence [+]
Bcl2 | Mus musculus | 10090 | length:236
MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPA
VHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTP
FTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNR
HLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
VHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTP
FTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNR
HLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
Structure links:
- Smartdomain prediction information: SM00265
- Smartdomain prediction information: SM00337
- Prosite motif and domain information: PS01080
- Prosite motif and domain information: PS01258
- Prosite motif and domain information: PS01259
- Prosite motif and domain information: PS01260
- Interpro domain information: P10417
- PFAM domain and domain family information: P10417
Evolution [+]
View protein alignment and tree with Jalview:  
Explore tree at phylomeDB:   Click here.
Homologs list [+]
Name | Relationship | Species |
---|---|---|
BCL2_CHICK | orthology | Chicken |
BCL2 | orthology | Chimpanzee |
Q462R3_BOVIN | orthology | Cow |
BCL2 | orthology | Dog |
BCL2 | orthology | Fugu |
BCL2 | orthology | Gasterosteus |
BCL2 | orthology | Gorilla |
BCL2 | orthology | Horse |
BCL2 | orthology | Human |
BCL2 | orthology | Lyzard |
BCL2 | orthology | Macaca |
BCL2 | orthology | Medaka |
BCL2 | orthology | Monodelphis |
BCL2 | orthology | Orangutan |
Bcl2 | orthology | Rat |
BCL2 | orthology | Tetraodon |
BCL2 | orthology | Xenopus |
BCL2 | orthology | Zebra finch |
bcl2 | orthology | Zebrafish |
A_aegypti_AAEL001515-PA | paralogy | Aedes |
A_aegypti_AAEL001521-PA | paralogy | Aedes |
Q2PHG8_ANOGA | paralogy | Anopheles |
NP_001026091.1 | paralogy | Chicken |
BCLX_CHICK | paralogy | Chicken |
MCL1 | paralogy | Chimpanzee |
BCL2L2 | paralogy | Chimpanzee |
BCL2L1 | paralogy | Chimpanzee |
XR_024448.1 | paralogy | Chimpanzee |
BAX | paralogy | Chimpanzee |
BCL2A1 | paralogy | Chimpanzee |
C_intestinalis_ENSCINP00000000654 | paralogy | Ciona |
C_intestinalis_ENSCINP00000024813 | paralogy | Ciona |
C_intestinalis_ENSCINP00000019812 | paralogy | Ciona |
IPI00908204.1 | paralogy | Cow |
NP_001070954.1 | paralogy | Cow |
NP_001071386.1 | paralogy | Cow |
BAX_BOVIN | paralogy | Cow |
NP_001092676.1 | paralogy | Cow |
BCLW_BOVIN | paralogy | Cow |
B2LA1_BOVIN | paralogy | Cow |
MCL1_CANFA | paralogy | Dog |
BCL2A1 | paralogy | Dog |
NP_001018644.1 | paralogy | Dog |
NP_001003072.1 | paralogy | Dog |
debcl | paralogy | Fly |
Buffy | paralogy | Fly |
BAX | paralogy | Fugu |
BCL2L1 (3 of 6) | paralogy | Fugu |
BCL2L1 (2 of 6) | paralogy | Fugu |
T_rubripes_ENSTRUP00000006891 | paralogy | Fugu |
BCL2L1 (5 of 6) | paralogy | Fugu |
BCL2L1 (4 of 6) | paralogy | Fugu |
MCL1 | paralogy | Fugu |
BCL2L1 (1 of 6) | paralogy | Fugu |
BCL2L1 (6 of 6) | paralogy | Fugu |
BAX | paralogy | Gasterosteus |
MCL1 | paralogy | Gasterosteus |
BCL2L1 (2 of 2) | paralogy | Gasterosteus |
BCL2L1 (1 of 2) | paralogy | Gasterosteus |
G_aculeatus_ENSGACP00000018978 | paralogy | Gasterosteus |
MCL1 | paralogy | Gorilla |
BOK | paralogy | Gorilla |
BCL2L2 | paralogy | Gorilla |
BAK1 | paralogy | Gorilla |
BAX | paralogy | Gorilla |
MCL1 | paralogy | Horse |
BAK1 | paralogy | Horse |
BCL2L2 | paralogy | Horse |
BCL2L1 | paralogy | Horse |
BCL2A1 | paralogy | Horse |
BAX | paralogy | Human |
BAK1 | paralogy | Human |
BCL2L1 | paralogy | Human |
BOK | paralogy | Human |
BCL2L2 | paralogy | Human |
BCL2A1 | paralogy | Human |
MCL1 | paralogy | Human |
BAX | paralogy | Lyzard |
BOK | paralogy | Lyzard |
BAK1 | paralogy | Lyzard |
MCL1 | paralogy | Lyzard |
A_carolinensis_ENSACAP00000004550 | paralogy | Lyzard |
BCL2L1 | paralogy | Lyzard |
MCL1 | paralogy | Macaca |
BAX | paralogy | Macaca |
BCL2A1 | paralogy | Macaca |
BCL2L2 | paralogy | Macaca |
BOK | paralogy | Macaca |
BAK1 | paralogy | Macaca |
BCL2L1 | paralogy | Macaca |
MCL1 | paralogy | Medaka |
BCL2L1 | paralogy | Medaka |
BCL2A1 | paralogy | Monodelphis |
M_domestica_ENSMODP00000037249 | paralogy | Monodelphis |
M_domestica_ENSMODP00000005598 | paralogy | Monodelphis |
BAK1 | paralogy | Monodelphis |
BCL2L1 | paralogy | Monodelphis |
BAX | paralogy | Monodelphis |
BOK | paralogy | Monodelphis |
MCL1 | paralogy | Monodelphis |
Mcl1 | paralogy | Mouse |
Bcl2l1 | paralogy | Mouse |
Bak1 | paralogy | Mouse |
Bax | paralogy | Mouse |
Bcl2a1d | paralogy | Mouse |
Bcl2a1a | paralogy | Mouse |
Bok | paralogy | Mouse |
Bcl2a1a | paralogy | Mouse |
Bcl2l2 | paralogy | Mouse |
MCL1 | paralogy | Orangutan |
BCL2A1 | paralogy | Orangutan |
BOK | paralogy | Orangutan |
P_pygmaeus_ENSPPYP00000006150 | paralogy | Orangutan |
BCL2L1 | paralogy | Orangutan |
BCL2L2 | paralogy | Ornithorhynchus |
BOK | paralogy | Ornithorhynchus |
Q9MYW4_RABIT | paralogy | Rabbit |
MCL1 | paralogy | Rabbit |
BAK1 | paralogy | Rabbit |
BAX | paralogy | Rabbit |
BCL2A1 | paralogy | Rabbit |
RGD1565822_predicted | paralogy | Rat |
Bax | paralogy | Rat |
Bak1 | paralogy | Rat |
Bcl2a1 | paralogy | Rat |
LOC684140 | paralogy | Rat |
BCLX_RAT | paralogy | Rat |
Bok | paralogy | Rat |
T_nigroviridis_ENSTNIP00000017211 | paralogy | Tetraodon |
BCL2L1 (2 of 3) | paralogy | Tetraodon |
BCL2L1 (3 of 3) | paralogy | Tetraodon |
BOK (1 of 2) | paralogy | Tetraodon |
BCL2L1 (1 of 3) | paralogy | Tetraodon |
bax | paralogy | Xenopus |
BCL2L1 | paralogy | Xenopus |
bcl2l2 | paralogy | Xenopus |
BAK1 | paralogy | Xenopus |
MCL1 | paralogy | Xenopus |
BAX | paralogy | Zebra finch |
BCL2A1 | paralogy | Zebra finch |
BCL2L1 | paralogy | Zebra finch |
BOK | paralogy | Zebra finch |
bcl2l | paralogy | Zebrafish |
D_rerio_ENSDARP00000037180 | paralogy | Zebrafish |
baxa | paralogy | Zebrafish |
mcl1a | paralogy | Zebrafish |
mcl1b | paralogy | Zebrafish |
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0000082 | G1/S transition of mitotic cell cycle | biological_proccess | IDA |
GO:0000902 | cell morphogenesis | biological_proccess | IMP |
GO:0001101 | response to acid | biological_proccess | IDA |
GO:0001541 | ovarian follicle development | biological_proccess | IMP |
GO:0001658 | ureteric bud branching | biological_proccess | IGI |
GO:0001662 | behavioral fear response | biological_proccess | IMP |
GO:0001666 | response to hypoxia | biological_proccess | IEA |
GO:0001782 | B cell homeostasis | biological_proccess | IMP |
GO:0001952 | regulation of cell-matrix adhesion | biological_proccess | IMP |
GO:0002320 | lymphoid progenitor cell differentiation | biological_proccess | IMP |
GO:0002326 | B cell lineage commitment | biological_proccess | IMP |
GO:0002360 | T cell lineage commitment | biological_proccess | IMP |
GO:0002520 | immune system development | biological_proccess | IMP |
GO:0003014 | renal system process | biological_proccess | IMP |
GO:0006470 | protein amino acid dephosphorylation | biological_proccess | IDA |
GO:0006582 | melanin metabolic process | biological_proccess | IMP |
GO:0006800 | oxygen and reactive oxygen species metabolic process | biological_proccess | IMP |
GO:0006808 | regulation of nitrogen utilization | biological_proccess | IGI |
GO:0006916 | anti-apoptosis | biological_proccess | IMP |
GO:0006979 | response to oxidative stress | biological_proccess | IMP |
GO:0007015 | actin filament organization | biological_proccess | IMP |
GO:0007569 | cell aging | biological_proccess | IMP |
GO:0007584 | response to nutrient | biological_proccess | IEA |
GO:0008219 | cell death | biological_proccess | IMP |
GO:0008584 | male gonad development | biological_proccess | IGI |
GO:0009408 | response to heat | biological_proccess | IEA |
GO:0009605 | response to external stimulus | biological_proccess | IMP |
GO:0009636 | response to toxin | biological_proccess | IMP |
GO:0009791 | post-embryonic development | biological_proccess | IMP |
GO:0009887 | organ morphogenesis | biological_proccess | IMP |
GO:0010035 | response to inorganic substance | biological_proccess | IEA |
GO:0010224 | response to UV-B | biological_proccess | IMP |
GO:0010332 | response to gamma radiation | biological_proccess | IMP |
GO:0010468 | regulation of gene expression | biological_proccess | IMP |
GO:0010523 | negative regulation of calcium ion transport into cytosol | biological_proccess | IGI |
GO:0010559 | regulation of glycoprotein biosynthetic process | biological_proccess | IMP |
GO:0014031 | mesenchymal cell development | biological_proccess | IMP |
GO:0014042 | positive regulation of neuron maturation | biological_proccess | IMP |
GO:0014911 | positive regulation of smooth muscle cell migration | biological_proccess | IMP |
GO:0016337 | cell-cell adhesion | biological_proccess | IMP |
GO:0018107 | peptidyl-threonine phosphorylation | biological_proccess | IDA |
GO:0021747 | cochlear nucleus development | biological_proccess | IMP |
GO:0022612 | gland morphogenesis | biological_proccess | IMP |
GO:0030097 | hemopoiesis | biological_proccess | IMP |
GO:0030279 | negative regulation of ossification | biological_proccess | IMP |
GO:0030308 | negative regulation of cell growth | biological_proccess | IMP |
GO:0030336 | negative regulation of cell migration | biological_proccess | IMP |
GO:0031000 | response to caffeine | biological_proccess | IEA |
GO:0031103 | axon regeneration | biological_proccess | IDA |
GO:0031647 | regulation of protein stability | biological_proccess | IMP |
GO:0032469 | endoplasmic reticulum calcium ion homeostasis | biological_proccess | IGI |
GO:0032835 | glomerulus development | biological_proccess | IMP |
GO:0032880 | regulation of protein localization | biological_proccess | IMP |
GO:0033033 | negative regulation of myeloid cell apoptosis | biological_proccess | IDA |
GO:0033077 | T cell differentiation in the thymus | biological_proccess | IMP |
GO:0033138 | positive regulation of peptidyl-serine phosphorylation | biological_proccess | IGI |
GO:0033689 | negative regulation of osteoblast proliferation | biological_proccess | IMP |
GO:0034097 | response to cytokine stimulus | biological_proccess | IMP |
GO:0035265 | organ growth | biological_proccess | IMP |
GO:0040018 | positive regulation of multicellular organism growth | biological_proccess | IMP |
GO:0042493 | response to drug | biological_proccess | IDA |
GO:0042542 | response to hydrogen peroxide | biological_proccess | IMP |
GO:0043029 | T cell homeostasis | biological_proccess | IGI |
GO:0043085 | positive regulation of catalytic activity | biological_proccess | IMP |
GO:0043375 | CD8-positive, alpha-beta T cell lineage commitment | biological_proccess | IMP |
GO:0043434 | response to peptide hormone stimulus | biological_proccess | IEA |
GO:0043524 | negative regulation of neuron apoptosis | biological_proccess | IDA |
GO:0043583 | ear development | biological_proccess | IMP |
GO:0043627 | response to estrogen stimulus | biological_proccess | IEA |
GO:0045471 | response to ethanol | biological_proccess | IEA |
GO:0045636 | positive regulation of melanocyte differentiation | biological_proccess | IMP |
GO:0045930 | negative regulation of mitotic cell cycle | biological_proccess | IDA |
GO:0046671 | negative regulation of retinal cell programmed cell death | biological_proccess | IMP |
GO:0048041 | focal adhesion formation | biological_proccess | IMP |
GO:0048087 | positive regulation of pigmentation during development | biological_proccess | IMP |
GO:0048536 | spleen development | biological_proccess | IGI |
GO:0048538 | thymus development | biological_proccess | IMP |
GO:0048547 | gut morphogenesis | biological_proccess | IMP |
GO:0048589 | developmental growth | biological_proccess | IMP |
GO:0048599 | oocyte development | biological_proccess | IMP |
GO:0048743 | positive regulation of skeletal muscle fiber development | biological_proccess | IMP |
GO:0048753 | pigment granule organization | biological_proccess | IMP |
GO:0048873 | homeostasis of number of cells within a tissue | biological_proccess | IMP |
GO:0051384 | response to glucocorticoid stimulus | biological_proccess | IMP |
GO:0051726 | regulation of cell cycle | biological_proccess | IMP |
GO:0051789 | response to protein stimulus | biological_proccess | IMP |
GO:0001836 | release of cytochrome c from mitochondria | biological_proccess | IDA |
GO:0008284 | positive regulation of cell proliferation | biological_proccess | IDA |
GO:0031069 | hair follicle morphogenesis | biological_proccess | IMP |
GO:0045069 | regulation of viral genome replication | biological_proccess | IDA |
GO:0046902 | regulation of mitochondrial membrane permeability | biological_proccess | IDA |
GO:0051881 | regulation of mitochondrial membrane potential | biological_proccess | IDA |
GO:0007409 | axonogenesis | biological_proccess | IMP |
GO:0018105 | peptidyl-serine phosphorylation | biological_proccess | IDA |
GO:0000209 | protein polyubiquitination | biological_proccess | ISO |
GO:0006874 | cellular calcium ion homeostasis | biological_proccess | IDA |
GO:0001503 | ossification | biological_proccess | IMP |
GO:0001656 | metanephros development | biological_proccess | IMP |
GO:0042221 | response to chemical stimulus | biological_proccess | IDA |
GO:0001657 | ureteric bud development | biological_proccess | IMP |
GO:0030307 | positive regulation of cell growth | biological_proccess | ISO |
GO:0042100 | B cell proliferation | biological_proccess | ISO |
GO:0006915 | apoptosis | biological_proccess | IDA |
GO:0008285 | negative regulation of cell proliferation | biological_proccess | IMP |
GO:0016049 | cell growth | biological_proccess | IMP |
GO:0040007 | growth | biological_proccess | IMP |
GO:0030318 | melanocyte differentiation | biological_proccess | IMP |
GO:0030183 | B cell differentiation | biological_proccess | IMP |
GO:0008283 | cell proliferation | biological_proccess | IGI |
GO:0030217 | T cell differentiation | biological_proccess | IMP |
GO:0048066 | pigmentation during development | biological_proccess | IMP |
GO:0048545 | response to steroid hormone stimulus | biological_proccess | IMP |
GO:0001776 | leukocyte homeostasis | biological_proccess | IMP |
GO:0043066 | negative regulation of apoptosis | biological_proccess | IDA |
GO:0050790 | regulation of catalytic activity | biological_proccess | IMP |
GO:0001822 | kidney development | biological_proccess | IGI |
GO:0042981 | regulation of apoptosis | biological_proccess | IGI |
GO:0048070 | regulation of pigmentation during development | biological_proccess | IGI |
GO:0043067 | regulation of programmed cell death | biological_proccess | IGI |
GO:0051924 | regulation of calcium ion transport | biological_proccess | ISO |
GO:0051402 | neuron apoptosis | biological_proccess | IMP |
GO:0002260 | lymphocyte homeostasis | biological_proccess | IGI |
GO:0070059 | apoptosis in response to endoplasmic reticulum stress | biological_proccess | ISS |
GO:0042493 | response to drug | biological_proccess | IEA |
GO:0006916 | anti-apoptosis | biological_proccess | IEA |
GO:0043524 | negative regulation of neuron apoptosis | biological_proccess | IEA |
GO:0010039 | response to iron ion | biological_proccess | IEA |
GO:0043497 | regulation of protein heterodimerization activity | biological_proccess | IEA |
GO:0034097 | response to cytokine stimulus | biological_proccess | IEA |
GO:0008219 | cell death | biological_proccess | IEA |
GO:0009636 | response to toxin | biological_proccess | IEA |
GO:0070059 | apoptosis in response to endoplasmic reticulum stress | biological_proccess | IEA |
GO:0035094 | response to nicotine | biological_proccess | IEA |
GO:0051607 | defense response to virus | biological_proccess | IEA |
GO:0043496 | regulation of protein homodimerization activity | biological_proccess | IEA |
GO:0051924 | regulation of calcium ion transport | biological_proccess | IEA |
GO:0042100 | B cell proliferation | biological_proccess | IEA |
GO:0032848 | negative regulation of cellular pH reduction | biological_proccess | IEA |
GO:0046688 | response to copper ion | biological_proccess | IEA |
GO:0051412 | response to corticosterone stimulus | biological_proccess | IEA |
GO:0010044 | response to aluminum ion | biological_proccess | IEA |
GO:0051593 | response to folic acid | biological_proccess | IEA |
GO:0008134 | transcription factor binding | mollecular_function | IPI |
GO:0016563 | transcription activator activity | mollecular_function | IDA |
GO:0046982 | protein heterodimerization activity | mollecular_function | IPI |
GO:0005515 | protein binding | mollecular_function | IPI |
GO:0042803 | protein homodimerization activity | mollecular_function | IEA |
GO:0046982 | protein heterodimerization activity | mollecular_function | IEA |
GO:0002020 | protease binding | mollecular_function | IEA |
GO:0051434 | BH3 domain binding | mollecular_function | IEA |
GO:0000159 | protein phosphatase type 2A complex | cell_component | IDA |
GO:0005622 | intracellular | cell_component | IDA |
GO:0005624 | membrane fraction | cell_component | IDA |
GO:0005634 | nucleus | cell_component | IDA |
GO:0005737 | cytoplasm | cell_component | IDA |
GO:0005739 | mitochondrion | cell_component | IDA |
GO:0005783 | endoplasmic reticulum | cell_component | IDA |
GO:0005789 | endoplasmic reticulum membrane | cell_component | IDA |
GO:0005792 | microsome | cell_component | IDA |
GO:0005829 | cytosol | cell_component | IDA |
GO:0005955 | calcineurin complex | cell_component | IDA |
GO:0016020 | membrane | cell_component | IEA |
GO:0031965 | nuclear membrane | cell_component | IDA |
GO:0031966 | mitochondrial membrane | cell_component | IDA |
GO:0043209 | myelin sheath | cell_component | IDA |
GO:0005741 | mitochondrial outer membrane | cell_component | IEA |
GO:0016021 | integral to membrane | cell_component | IEA |
GO:0005737 | cytoplasm | cell_component | IEA |
GO:0005634 | nucleus | cell_component | IEA |
GO:0005739 | mitochondrion | cell_component | IEA |
GO:0031965 | nuclear membrane | cell_component | IEA |
Check GO Evidence Codes here
miRNAs [+]
miRNA | Regulation | Description | Pubmed |
---|---|---|---|
mmu-miR-181a | siRNA anti-miRNA | The 3_ UTR elements of several predicted targets of miR-181a were fused to a luciferase reporter, and we examined the ability of a synthetic miR-181a small interfering RNA (siRNA) duplex to repress the expression of、 these constructs in HeLa cells. Relative to transfection of a control siRNA, miR-181a significantly down-regulated reporters fused to the 3_ UTRs of the TCR_ chain, CD69, and Bcl2 (Fig. 4). | Ref. |
Curated Isoforms [+]
Transcript | Translation |
---|---|
OTTMUST00000052517 * | OTTMUSP00000024915 * |
Info from The Vertebrate Genome Annotation (VEGA) database.
(*) Canonical transcript and translation forms.
Information from other databases [+]
- Gene info from MGI [?] MGI:88138
- Ensembl genome browser [?] : ENSMUSG00000057329
- Expression info from Arrayexpress [?] : ENSMUSG00000057329
- Protein expression from Protein Atlas: [?] ENSMUSG00000057329
- Community gene edition from Wikigenes: [?] 12043
Click on [?] for more information.