BCL2L1 (Mus musculus)

Description [+]

Synonyms: BCL2L1, BCL2L1, BCL2-LIKE 1, BCL(X)L, BCL-X, BCL-XL, BCL-XS, BCLX
Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Rodentia; Mus musculus
Short gene description: BCL2-like 1 Gene [Source:MGI (curated);Acc:Bcl2l1-001]
Family: Bcl-2 family : multidomain Bcl-2
Process: apoptosis,
Pathways: intrinsic pathway, pre-mitochondrial signaling events,
Criteria: manually curated
Curator comment:
Human ortholog(s): BCL2L1
WIKI: BCL2L1-M_musculus

References [+]

Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes.
Fang W, Rivard JJ, Mueller DL, Behrens TW
We report the cloning and initial characterization of the mouse homologues of the bcl-2-related gene, bcl-x. We compare these to the two major isoforms of human bcl-x that were previously identified, bcl-xLong (bcl-xL) which has death repressor activity similar to bcl-2, and bcl-xShort (bcl-xS), an alternative mRNA splice product that deletes a highly conserved domain shared by bcl-2 family members and promotes cell death in transfection studies. In addition to murine (m) bcl-xL and mbcl-xS, we have cloned a novel cDNA isoform that we designate mbcl-x delta TM. This cDNA deletes, by means of alternative splicing, the carboxy terminal transmembrane domain of bcl-x and is predicted to be a soluble, rather than membrane-bound, protein. We found that mbcl-x mRNA is highly inducible in splenocytes stimulated with either anti-CD3 Abs or LPS/dextran sulfate, and that the major species of mbcl-x mRNA in a variety of cell lines and tissues was the xL isoform. Transfection of mbcl-xL or mbcl-xS into Hela cells resulted in targeting primarily to mitochondria, whereas mbcl-x delta TM localized diffusely throughout the cytosol. Overexpression of the novel delta TM isoform in an IL-3-dependent cell line delayed the onset of apoptosis induced by growth factor withdrawal. Thus, a naturally-occurring form of mbcl-x present in lymphocytes that does not localize to the mitochondrial membrane is functional in preventing apoptotic cell death. Moreover, these data suggest that bcl-x provides a life signal in activated lymphocytes. J Immunol. 1994 Nov 15;153(10):4388-98.

References from Human ortholog(s):

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.
Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G, Thompson CB
We report the isolation of bcl-x, a bcl-2-related gene that can function as a bcl-2-independent regulator of programmed cell death (apoptosis). Alternative splicing results in two distinct bcl-x mRNAs. The protein product of the larger mRNA, bcl-xL, is similar in size and predicted structure to Bcl-2. When stably transfected into an IL-3-dependent cell line, bcl-xL inhibits cell death upon growth factor withdrawal at least as well as bcl-2. Surprisingly, the second mRNA species, bcl-xS, encodes a protein that inhibits the ability of bcl-2 to enhance the survival of growth factor-deprived cells. In vivo, bcl-xS mRNA is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, bcl-xL is found in tissues containing long-lived postmitotic cells, such as adult brain. Together these data suggest that bcl-x plays an important role in both positive and negative regulation of programmed cell death. Cell. 1993 Aug 27;74(4):597-608.

Structure & Sequence [+]

Pfam domains: (Pfam is a large collection of protein families.)

Source	Domain Name	Start	End
PFAM A	BH4	1	27
PFAM A	Bcl-2	90	188

Protein sequence [+]

Structure links:

Smartdomain prediction information: SM00265
Smartdomain prediction information: SM00337
Prosite motif and domain information: PS01080
Prosite motif and domain information: PS01259
Prosite motif and domain information: PS01260
Prosite motif and domain information: PS01258
Interpro domain information: Q64373
PFAM domain and domain family information: Q64373

Evolution [+]

Name	Relationship	Species
BCLX_CHICK	orthology	Chicken
BCL2L1	orthology	Chimpanzee
NP_001070954.1	orthology	Cow
NP_001003072.1	orthology	Dog
BCL2L1 (2 of 6)	orthology	Fugu
BCL2L1 (4 of 6)	orthology	Fugu
BCL2L1 (3 of 6)	orthology	Fugu
BCL2L1 (5 of 6)	orthology	Fugu
BCL2L1 (6 of 6)	orthology	Fugu
BCL2L1 (1 of 6)	orthology	Fugu
BCL2L1 (1 of 2)	orthology	Gasterosteus
BCL2L1 (2 of 2)	orthology	Gasterosteus
BCL2L1	orthology	Horse
BCL2L1	orthology	Human
BCL2L1	orthology	Lyzard
BCL2L1	orthology	Macaca
BCL2L1	orthology	Medaka
BCL2L1	orthology	Monodelphis
BCL2L1	orthology	Orangutan
Q9MYW4_RABIT	orthology	Rabbit
BCLX_RAT	orthology	Rat
BCL2L1 (3 of 3)	orthology	Tetraodon
BCL2L1 (1 of 3)	orthology	Tetraodon
BCL2L1 (2 of 3)	orthology	Tetraodon
BCL2L1	orthology	Xenopus
BCL2L1	orthology	Zebra finch
bcl2l	orthology	Zebrafish
A_aegypti_AAEL001521-PA	paralogy	Aedes
A_aegypti_AAEL001515-PA	paralogy	Aedes
Q2PHG8_ANOGA	paralogy	Anopheles
BOK_CHICK	paralogy	Chicken
BCL2_CHICK	paralogy	Chicken
NP_001026091.1	paralogy	Chicken
NP_990197.1	paralogy	Chicken
XR_024448.1	paralogy	Chimpanzee
BCL2	paralogy	Chimpanzee
BAX	paralogy	Chimpanzee
BCL2L2	paralogy	Chimpanzee
C_intestinalis_ENSCINP00000000654	paralogy	Ciona
BCLW_BOVIN	paralogy	Cow
NP_001092338.1	paralogy	Cow
Q462R3_BOVIN	paralogy	Cow
NP_001071386.1	paralogy	Cow
B2LA1_BOVIN	paralogy	Cow
BAX_BOVIN	paralogy	Cow
NP_001018644.1	paralogy	Dog
BCL2	paralogy	Dog
Buffy	paralogy	Fly
debcl	paralogy	Fly
BCL2	paralogy	Fugu
BOK (1 of 2)	paralogy	Fugu
MCL1	paralogy	Fugu
BAX	paralogy	Fugu
BCL2	paralogy	Gasterosteus
BAX	paralogy	Gasterosteus
BOK (1 of 2)	paralogy	Gasterosteus
BOK (2 of 2)	paralogy	Gasterosteus
G_aculeatus_ENSGACP00000018978	paralogy	Gasterosteus
BCL2	paralogy	Gorilla
BAX	paralogy	Gorilla
BOK	paralogy	Gorilla
BCL2L2	paralogy	Gorilla
BAK1	paralogy	Gorilla
BCL2	paralogy	Horse
BCL2L2	paralogy	Horse
BAK1	paralogy	Horse
BOK	paralogy	Human
BCL2L2	paralogy	Human
BAK1	paralogy	Human
BAX	paralogy	Human
BCL2	paralogy	Human
BAK1	paralogy	Lyzard
BOK	paralogy	Lyzard
MCL1	paralogy	Lyzard
BCL2	paralogy	Lyzard
A_carolinensis_ENSACAP00000004550	paralogy	Lyzard
BAX	paralogy	Lyzard
BAK1	paralogy	Macaca
BCL2	paralogy	Macaca
BCL2L2	paralogy	Macaca
BAX	paralogy	Macaca
BOK	paralogy	Macaca
BAX	paralogy	Medaka
BCL2	paralogy	Medaka
BCL2	paralogy	Monodelphis
M_domestica_ENSMODP00000026730	paralogy	Monodelphis
M_domestica_ENSMODP00000037249	paralogy	Monodelphis
BOK	paralogy	Monodelphis
M_domestica_ENSMODP00000005598	paralogy	Monodelphis
BAK1	paralogy	Monodelphis
BAX	paralogy	Monodelphis
Bax	paralogy	Mouse
Bok	paralogy	Mouse
Bcl2l2	paralogy	Mouse
Bcl2	paralogy	Mouse
Mcl1	paralogy	Mouse
Bak1	paralogy	Mouse
P_pygmaeus_ENSPPYP00000006150	paralogy	Orangutan
BCL2	paralogy	Orangutan
BOK	paralogy	Orangutan
BCL2L2	paralogy	Ornithorhynchus
BOK	paralogy	Ornithorhynchus
BAK1	paralogy	Rabbit
BAX	paralogy	Rabbit
Bcl2	paralogy	Rat
Bok	paralogy	Rat
R_norvegicus_ENSRNOP00000052069	paralogy	Rat
RGD1565822_predicted	paralogy	Rat
Bax	paralogy	Rat
Bak1	paralogy	Rat
LOC684140	paralogy	Rat
BOK (2 of 2)	paralogy	Tetraodon
T_nigroviridis_ENSTNIP00000017211	paralogy	Tetraodon
BOK (1 of 2)	paralogy	Tetraodon
BCL2	paralogy	Tetraodon
BCL2	paralogy	Xenopus
BAK1	paralogy	Xenopus
bcl2l2	paralogy	Xenopus
bax	paralogy	Xenopus
BCL2A1	paralogy	Zebra finch
BCL2	paralogy	Zebra finch
BOK	paralogy	Zebra finch
mcl1a	paralogy	Zebrafish
D_rerio_ENSDARP00000037180	paralogy	Zebrafish
baxa	paralogy	Zebrafish
BAXB	paralogy	Zebrafish
boka	paralogy	Zebrafish
bcl2	paralogy	Zebrafish
mcl1b	paralogy	Zebrafish

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0001541	ovarian follicle development	biological_proccess	IGI
GO:0001701	in utero embryonic development	biological_proccess	IMP
GO:0001836	release of cytochrome c from mitochondria	biological_proccess	IGI
GO:0007281	germ cell development	biological_proccess	IGI
GO:0007283	spermatogenesis	biological_proccess	IGI
GO:0008284	positive regulation of cell proliferation	biological_proccess	IDA
GO:0008584	male gonad development	biological_proccess	IMP
GO:0009314	response to radiation	biological_proccess	IMP
GO:0009566	fertilization	biological_proccess	IGI
GO:0040007	growth	biological_proccess	IMP
GO:0043065	positive regulation of apoptosis	biological_proccess	IDA
GO:0043524	negative regulation of neuron apoptosis	biological_proccess	IGI
GO:0045768	positive regulation of anti-apoptosis	biological_proccess	IDA
GO:0046898	response to cycloheximide	biological_proccess	IDA
GO:0051789	response to protein stimulus	biological_proccess	IDA
GO:0042981	regulation of apoptosis	biological_proccess	IEA
GO:0043434	response to peptide hormone stimulus	biological_proccess	IEA
GO:0001666	response to hypoxia	biological_proccess	IEA
GO:0010035	response to inorganic substance	biological_proccess	IEA
GO:0014070	response to organic cyclic substance	biological_proccess	IEA
GO:0042542	response to hydrogen peroxide	biological_proccess	IEA
GO:0006979	response to oxidative stress	biological_proccess	IEA
GO:0010243	response to organic nitrogen	biological_proccess	IEA
GO:0001541	ovarian follicle development	biological_proccess	IEA
GO:0006916	anti-apoptosis	biological_proccess	IEA
GO:0010288	response to lead ion	biological_proccess	IEA
GO:0001836	release of cytochrome c from mitochondria	biological_proccess	IEA
GO:0034097	response to cytokine stimulus	biological_proccess	IEA
GO:0051881	regulation of mitochondrial membrane potential	biological_proccess	IEA
GO:0046902	regulation of mitochondrial membrane permeability	biological_proccess	IEA
GO:0006916	anti-apoptosis	biological_proccess	IDA
GO:0008283	cell proliferation	biological_proccess	IDA
GO:0006915	apoptosis	biological_proccess	IDA
GO:0034097	response to cytokine stimulus	biological_proccess	ISO
GO:0043066	negative regulation of apoptosis	biological_proccess	ISO
GO:0046982	protein heterodimerization activity	mollecular_function	IPI
GO:0005515	protein binding	mollecular_function	IEA
GO:0043027	caspase inhibitor activity	mollecular_function	IEA
GO:0042802	identical protein binding	mollecular_function	IEA
GO:0005515	protein binding	mollecular_function	IPI
GO:0005622	intracellular	cell_component	IDA
GO:0005829	cytosol	cell_component	IDA
GO:0031966	mitochondrial membrane	cell_component	IDA
GO:0016020	membrane	cell_component	IEA
GO:0005741	mitochondrial outer membrane	cell_component	IEA
GO:0005740	mitochondrial envelope	cell_component	IEA
GO:0005739	mitochondrion	cell_component	IEA
GO:0005737	cytoplasm	cell_component	IEA
GO:0005741	mitochondrial outer membrane	cell_component	EXP
GO:0016021	integral to membrane	cell_component	IEA
GO:0005739	mitochondrion	cell_component	IDA
GO:0044429	mitochondrial part	cell_component	IDA

Check GO Evidence Codes here

KEGG Pathways [+]

Curated Isoforms [+]

Transcript	Translation
OTTMUST00000037600 *	OTTMUSP00000016850 *
OTTMUST00000037601	OTTMUSP00000016851
OTTMUST00000037602
OTTMUST00000037603
OTTMUST00000037604	OTTMUSP00000016852
OTTMUST00000037605	OTTMUSP00000016853
OTTMUST00000037606	OTTMUSP00000016854

Information from other databases [+]

Gene related links:

Gene info from MGI [?] MGI:88139
Ensembl genome browser [?] : ENSMUSG00000007659
Expression info from Arrayexpress [?] : ENSMUSG00000007659
Protein expression from Protein Atlas: [?] ENSMUSG00000007659
Community gene edition from Wikigenes: [?] 12048

Protein related links:

Uniprot protein info: Q64373
PIR protein info: Q64373
Protein interactions from IntAct: Q64373

Other links

entrezgene: 12048
refseq_dna: NM_009743
refseq_peptide: NP_033873

Click on [?] for more information.